Zobrazeno 1 - 10
of 1 004
pro vyhledávání: '"W Schindler"'
Autor:
Yildirim Dogan, Cecilia N. Barese, Jeffrey W. Schindler, John K. Yoon, Zeenath Unnisa, Swaroopa Guda, Mary E. Jacobs, Christine Oborski, Tim Maiwald, Diana L. Clarke, Axel Schambach, Richard Pfeifer, Claudia Harper, Chris Mason, Niek P. van Til
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 464-487 (2022)
Pompe disease is a rare genetic neuromuscular disorder caused by acid α-glucosidase (GAA) deficiency resulting in lysosomal glycogen accumulation and progressive myopathy. Enzyme replacement therapy, the current standard of care, penetrates poorly i
Externí odkaz:
https://doaj.org/article/19aee40652b94df1a4979d0e41238f5c
Autor:
Alishan S. Amirali, Jacquelin C. Hecker, Hector L. Figueroa-Monsanto, Devin P. Effinger, Rodrigo A. Montoro, Hank P. Jedema, Caleb D. Vogt, Amy Hauck Newman, Charles W. Schindler, Charles W. Bradberry
Publikováno v:
Addiction Neuroscience, Vol 5, Iss , Pp 100065- (2023)
We recently reported an economic choice task in which squirrel monkeys chose between differing amounts of remifentanil, a fast-acting opioid, or a food reward to develop a preclinical screen for evaluating potential pharmacotherapies for opioid depen
Externí odkaz:
https://doaj.org/article/92e06a43f74b4b2d96ba6e7f0ef970c3
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Conditioned stimuli (CS) associated with alcohol ingestion are thought to play a role in relapse by producing a craving that in turn increases motivation to drink which increases ethanol-seeking and disrupts other ongoing behavior. Alternatively, suc
Externí odkaz:
https://doaj.org/article/a1bc010cfb1b4031afe47f03c077b187
Autor:
Michael R. Chojnacki, Eric B. Thorndike, John S. Partilla, Kenner C. Rice, Charles W. Schindler, Michael H. Baumann
Publikováno v:
J Pharmacol Exp Ther
Synthetic cathinones are a class of new psychoactive substances that display psychomotor stimulant properties, and novel cathinone analogs continue to emerge in illicit drug markets worldwide. The aim of the present study was to characterize the phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26e579fa85a9d563fe04c4509b62646
https://doi.org/10.1124/jpet.122.001478
https://doi.org/10.1124/jpet.122.001478
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 302 (2022)
Pompe disease is an inherited neuromuscular disorder caused by deficiency of the lysosomal enzyme acid alpha-glucosidase (GAA). The most severe form is infantile-onset Pompe disease, presenting shortly after birth with symptoms of cardiomyopathy, res
Externí odkaz:
https://doaj.org/article/c76acd8f3abf4980b14f9ce876629d2b
Autor:
Shelby A. McGriff, Michael R. Chojnacki, Eric B. Thorndike, Kenner C. Rice, Michael H. Baumann, Charles W. Schindler
Publikováno v:
Psychopharmacology. 239:3723-3730
Synthetic phenethylamine (PEA) analogs, such as β-methylphenethylamine (BMPEA) and N,α-diethylphenethylamine (DEPEA), are often found in dietary supplements, despite regulations prohibiting their sale. PEA analogs are structurally related to amphet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2cf2793174e02cb0beedc8afc88fa1b
https://doi.org/10.1007/s00213-022-06246-x
https://doi.org/10.1007/s00213-022-06246-x
Autor:
Robert N. Plasschaert, Mark P. DeAndrade, Fritz Hull, Quoc Nguyen, Tara Peterson, Aimin Yan, Mariana Loperfido, Cristina Baricordi, Luigi Barbarossa, John K. Yoon, Yildirim Dogan, Zeenath Unnisa, Jeffrey W. Schindler, Niek P. van Til, Luca Biasco, Chris Mason
Publikováno v:
Molecular Therapy. 30:3209-3225
Hematopoietic stem/progenitor cell gene therapy (HSPC-GT) has shown clear neurological benefit in rare diseases, which is achieved through the engraftment of genetically modified microglia-like cells (MLCs) in the brain. Still, the engraftment dynami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5df9c34055a087315833104af0a261
https://doi.org/10.1016/j.ymthe.2022.05.022
https://doi.org/10.1016/j.ymthe.2022.05.022
Publikováno v:
Management Science. 68:7018-7033
We propose a method to extract the risk-neutral distribution of firm-specific stock returns using both options and credit default swaps (CDS). Options and CDS provide information about the central part and the left tail of the distribution, respectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4b5d210cca67540c53c447d0e06d62a
https://doi.org/10.1287/mnsc.2021.4170
https://doi.org/10.1287/mnsc.2021.4170
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215689 (2019)
Inflammation plays a critical role in initiation of adaptive immunity, pathogen clearance and tissue repair. Interleukin (IL)-1β is a potent pro-inflammatory cytokine and therefore its production is tightly regulated: its secretion requires the asse
Externí odkaz:
https://doaj.org/article/f55fb403127446948be0b8ddf0354ca5
Autor:
Gernot Marx, Patrick Meybohm, Tobias Schuerholz, Gösta Lotz, Mandy Ledinko, Achim W Schindler, Rolf Rossaint, Kai Zacharowski
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0213057 (2019)
IntroductionBalanced fluid replacement solutions can possibly reduce the risks for electrolyte imbalances, for acid-base imbalances, and thus for renal failure. To assess the intraoperative change of base excess (BE) and chloride in serum after treat
Externí odkaz:
https://doaj.org/article/a123c61299764c8e8561e7fab7c5d2a6