Zobrazeno 1 - 10
of 23
pro vyhledávání: '"W Samantha N Jayasekara"'
Autor:
Mary Speir, W Samantha N Jayasekara, Sunil Sapkota, Arwaf Alharbi, Olivier F Laczka, Michael P Gantier
Publikováno v:
Lupus Science and Medicine, Vol 10, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/467f2a6a69fd442f9f01212f514a811a
Autor:
Jesse J. Balic, Hassan Albargy, Kevin Luu, Francis J. Kirby, W. Samantha N. Jayasekara, Finbar Mansell, Daniel J. Garama, Dominic De Nardo, Nikola Baschuk, Cynthia Louis, Fiachra Humphries, Katherine Fitzgerald, Eicke Latz, Daniel J. Gough, Ashley Mansell
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
TLR4 signalling can reprogram the metabolism of macrophages to be more glycolytic and proinflammatory. Here the authors show that LPS and TLR4 signalling results in recruitment of TBK1, which in turn phosphorylates serine 727 on STAT3 to enable a pro
Externí odkaz:
https://doaj.org/article/56d3ddfe137f4fb1a1f4f01e629a3c2e
Autor:
Evangeline R. Jackson, Ryan J. Duchatel, Dilana E. Staudt, Mika L. Persson, Abdul Mannan, Sridevi Yadavilli, Sarah Parackal, Shaye Game, Wai Chin Chong, W. Samantha N. Jayasekara, Marion Le Grand, Padraic S. Kearney, Alicia M. Douglas, Izac J. Findlay, Zacary P. Germon, Holly P. McEwen, Tyrone S. Beitaki, Adjanie Patabendige, David A. Skerrett-Byrne, Brett Nixon, Nathan D. Smith, Bryan Day, Neevika Manoharan, Sumanth Nagabushan, Jordan R. Hansford, Dinisha Govender, Geoff B. McCowage, Ron Firestein, Meegan Howlett, Raelene Endersby, Nicholas G. Gottardo, Frank Alvaro, Sebastian M. Waszak, Martin R. Larsen, Yolanda Colino-Sanguino, Fatima Valdes-Mora, Andria Rakotomalala, Samuel Meignan, Eddy Pasquier, Nicolas André, Esther Hulleman, David D. Eisenstat, Nicholas A. Vitanza, Javad Nazarian, Carl Koschmann, Sabine Mueller, Jason E. Cain, Matthew D. Dun
Publikováno v:
Cancer Research. :OF1-OF17
Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the most lethal of childhood cancers. Palliative radiotherapy is the only established treatment, with median patient survival of 9 to 11 months. ONC201 is a DRD2 a
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-17 (2018)
Abstract Background Different cell types possess different copies of mtDNA to support their specific requirements for cellular metabolism. Cell-specific mtDNA copy numbers are established through cell-specific mtDNA replication during cell differenti
Externí odkaz:
https://doaj.org/article/7a31a962090b498ba018dfcf9199bf78
Autor:
Wai C. Chong, W. Samantha N. Jayasekara, Vijesh G. Vaghjiani, Sarah Parackal, Claire Sun, Dean Popovski, Elizabeth M. Algar, Ron Firestein, Paul J. Wood, Sara Khan, Annie Huang, David M. Ashley, Peter Downie, Jason E. Cain
Publikováno v:
Cancers, Vol 13, Iss 20, p 5145 (2021)
Atypical teratoid rhabdoid tumour (ATRT) is a rare but highly aggressive undifferentiated solid tumour arising in the central nervous system and predominantly affecting infants and young children. ATRT is exclusively characterized by the inactivation
Externí odkaz:
https://doaj.org/article/bb3b4997fe2446c183e6b612dbdfe97f
Autor:
Matthew D. Dun, Jason E. Cain, Sabine Mueller, Carl Koschmann, Javad Nazarian, Nicholas A. Vitanza, David D. Eisenstat, Esther Hulleman, Nicolas André, Eddy Pasquier, Samuel Meignan, Andria Rakotomalala, Fatima Valdes-Mora, Yolanda Colino-Sanguino, Martin R. Larsen, Sebastian M. Waszak, Frank Alvaro, Nicholas G. Gottardo, Raelene Endersby, Meegan Howlett, Ron Firestein, Geoff B. McCowage, Dinisha Govender, Jordan R. Hansford, Sumanth Nagabushan, Neevika Manoharan, Bryan Day, Nathan D. Smith, Brett Nixon, David A. Skerrett-Byrne, Adjanie Patabendige, Tyrone S. Beitaki, Holly P. McEwen, Zacary P. Germon, Izac J. Findlay, Alicia M. Douglas, Padraic S. Kearney, Marion Le Grand, W. Samantha N. Jayasekara, Wai Chin Chong, Shaye Game, Sarah Parackal, Sridevi Yadavilli, Abdul Mannan, Mika L. Persson, Dilana E. Staudt, Ryan J. Duchatel, Evangeline R. Jackson
All Supplementary Figures and their captions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9e68dc3c6f26e99f51f1fbaa7e5b3a
https://doi.org/10.1158/0008-5472.22892044
https://doi.org/10.1158/0008-5472.22892044
Autor:
Matthew D. Dun, Jason E. Cain, Sabine Mueller, Carl Koschmann, Javad Nazarian, Nicholas A. Vitanza, David D. Eisenstat, Esther Hulleman, Nicolas André, Eddy Pasquier, Samuel Meignan, Andria Rakotomalala, Fatima Valdes-Mora, Yolanda Colino-Sanguino, Martin R. Larsen, Sebastian M. Waszak, Frank Alvaro, Nicholas G. Gottardo, Raelene Endersby, Meegan Howlett, Ron Firestein, Geoff B. McCowage, Dinisha Govender, Jordan R. Hansford, Sumanth Nagabushan, Neevika Manoharan, Bryan Day, Nathan D. Smith, Brett Nixon, David A. Skerrett-Byrne, Adjanie Patabendige, Tyrone S. Beitaki, Holly P. McEwen, Zacary P. Germon, Izac J. Findlay, Alicia M. Douglas, Padraic S. Kearney, Marion Le Grand, W. Samantha N. Jayasekara, Wai Chin Chong, Shaye Game, Sarah Parackal, Sridevi Yadavilli, Abdul Mannan, Mika L. Persson, Dilana E. Staudt, Ryan J. Duchatel, Evangeline R. Jackson
Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the most lethal of childhood cancers. Palliative radiotherapy is the only established treatment, with median patient survival of 9 to 11 months. ONC201 is a DRD2 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2ec734b3b0e0b8ca6a532d4cfa2040
https://doi.org/10.1158/0008-5472.c.6651055.v1
https://doi.org/10.1158/0008-5472.c.6651055.v1
Autor:
Aleks C. Guanizo, Daniel J. Gough, Anette Szczepny, D. Neil Watkins, Quinton Luong, Vinod Ganju, Prudence A. Russell, Jasmine Chen, Daniel J. Garama, Dhilshan Jayasinghe, Chaitanya Inampudi, W. Samantha N. Jayasekara, Jason E. Cain
Publikováno v:
Oncogene. 41:138-145
Small cell lung cancer (SCLC) is an aggressive neuroendocrine cancer characterized by loss of function TP53 and RB1 mutations in addition to mutations in other oncogenes including MYC. Overexpression of MYC together with Trp53 and Rb1 loss in pulmona
Autor:
Christine L. White, W. Samantha N. Jayasekara, Daniel Picard, Jasmine Chen, D. Neil Watkins, Jason E. Cain, Marc Remke, Daniel J. Gough
Publikováno v:
Cancers, Vol 11, Iss 11, p 1702 (2019)
Medulloblastoma is the most common malignant brain tumor in children and represents 20% of all pediatric central nervous system neoplasms. While advances in surgery, radiation and chemotherapy have improved overall survival, the lifelong sequelae of
Externí odkaz:
https://doaj.org/article/db5d97d4f6854b1ba4b89447a82506f5
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-17 (2018)
Clinical Epigenetics
Clinical Epigenetics
Background Different cell types possess different copies of mtDNA to support their specific requirements for cellular metabolism. Cell-specific mtDNA copy numbers are established through cell-specific mtDNA replication during cell differentiation. Ho