Zobrazeno 1 - 10
of 32
pro vyhledávání: '"W Samantha N Jayasekara"'
Autor:
Tomalika R. Ullah, Matt D. Johansen, Katherine R. Balka, Rebecca L. Ambrose, Linden J. Gearing, James Roest, Julian P. Vivian, Sunil Sapkota, W. Samantha N. Jayasekara, Daniel S. Wenholz, Vina R. Aldilla, Jun Zeng, Stefan Miemczyk, Duc H. Nguyen, Nicole G. Hansbro, Rajan Venkatraman, Jung Hee Kang, Ee Shan Pang, Belinda J. Thomas, Arwaf S. Alharbi, Refaya Rezwan, Meredith O’Keeffe, William A. Donald, Julia I. Ellyard, Wilson Wong, Naresh Kumar, Benjamin T. Kile, Carola G. Vinuesa, Graham E. Kelly, Olivier F. Laczka, Philip M. Hansbro, Dominic De Nardo, Michael P. Gantier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract TANK-binding kinase 1 (TBK1) is a key signalling component in the production of type-I interferons, which have essential antiviral activities, including against SARS-CoV-2. TBK1, and its homologue IκB kinase-ε (IKKε), can also induce pro-
Externí odkaz:
https://doaj.org/article/780fdb67fa074e35823aa88357231e9d
Autor:
C. Dilanka Fernando, W. Samantha N. Jayasekara, Chaitanya Inampudi, Maija R.J. Kohonen-Corish, Wendy A. Cooper, Traude H. Beilharz, Tracy M. Josephs, Daniel J. Garama, Daniel J. Gough
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113033- (2023)
Summary: Signal transducer and activator of transcription 3 (STAT3) is a potent transcription factor necessary for life whose activity is corrupted in diverse diseases, including cancer. STAT3 biology was presumed to be entirely dependent on its acti
Externí odkaz:
https://doaj.org/article/0b416294b8d648a2b18c0473e3703a04
Autor:
Mary Speir, W Samantha N Jayasekara, Sunil Sapkota, Arwaf Alharbi, Olivier F Laczka, Michael P Gantier
Publikováno v:
Lupus Science and Medicine, Vol 10, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/467f2a6a69fd442f9f01212f514a811a
Autor:
Jesse J. Balic, Hassan Albargy, Kevin Luu, Francis J. Kirby, W. Samantha N. Jayasekara, Finbar Mansell, Daniel J. Garama, Dominic De Nardo, Nikola Baschuk, Cynthia Louis, Fiachra Humphries, Katherine Fitzgerald, Eicke Latz, Daniel J. Gough, Ashley Mansell
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
TLR4 signalling can reprogram the metabolism of macrophages to be more glycolytic and proinflammatory. Here the authors show that LPS and TLR4 signalling results in recruitment of TBK1, which in turn phosphorylates serine 727 on STAT3 to enable a pro
Externí odkaz:
https://doaj.org/article/56d3ddfe137f4fb1a1f4f01e629a3c2e
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-17 (2018)
Abstract Background Different cell types possess different copies of mtDNA to support their specific requirements for cellular metabolism. Cell-specific mtDNA copy numbers are established through cell-specific mtDNA replication during cell differenti
Externí odkaz:
https://doaj.org/article/7a31a962090b498ba018dfcf9199bf78
Autor:
Evangeline R. Jackson, Ryan J. Duchatel, Dilana E. Staudt, Mika L. Persson, Abdul Mannan, Sridevi Yadavilli, Sarah Parackal, Shaye Game, Wai Chin Chong, W. Samantha N. Jayasekara, Marion Le Grand, Padraic S. Kearney, Alicia M. Douglas, Izac J. Findlay, Zacary P. Germon, Holly P. McEwen, Tyrone S. Beitaki, Adjanie Patabendige, David A. Skerrett-Byrne, Brett Nixon, Nathan D. Smith, Bryan Day, Neevika Manoharan, Sumanth Nagabushan, Jordan R. Hansford, Dinisha Govender, Geoff B. McCowage, Ron Firestein, Meegan Howlett, Raelene Endersby, Nicholas G. Gottardo, Frank Alvaro, Sebastian M. Waszak, Martin R. Larsen, Yolanda Colino-Sanguino, Fatima Valdes-Mora, Andria Rakotomalala, Samuel Meignan, Eddy Pasquier, Nicolas André, Esther Hulleman, David D. Eisenstat, Nicholas A. Vitanza, Javad Nazarian, Carl Koschmann, Sabine Mueller, Jason E. Cain, Matthew D. Dun
Publikováno v:
Cancer Research. :OF1-OF17
Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the most lethal of childhood cancers. Palliative radiotherapy is the only established treatment, with median patient survival of 9 to 11 months. ONC201 is a DRD2 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00455c41f4c2b9385b8b6d6009aa81b3
https://doi.org/10.1158/0008-5472.can-23-0186
https://doi.org/10.1158/0008-5472.can-23-0186
Autor:
Matthew D. Dun, Jason E. Cain, Sabine Mueller, Carl Koschmann, Javad Nazarian, Nicholas A. Vitanza, David D. Eisenstat, Esther Hulleman, Nicolas André, Eddy Pasquier, Samuel Meignan, Andria Rakotomalala, Fatima Valdes-Mora, Yolanda Colino-Sanguino, Martin R. Larsen, Sebastian M. Waszak, Frank Alvaro, Nicholas G. Gottardo, Raelene Endersby, Meegan Howlett, Ron Firestein, Geoff B. McCowage, Dinisha Govender, Jordan R. Hansford, Sumanth Nagabushan, Neevika Manoharan, Bryan Day, Nathan D. Smith, Brett Nixon, David A. Skerrett-Byrne, Adjanie Patabendige, Tyrone S. Beitaki, Holly P. McEwen, Zacary P. Germon, Izac J. Findlay, Alicia M. Douglas, Padraic S. Kearney, Marion Le Grand, W. Samantha N. Jayasekara, Wai Chin Chong, Shaye Game, Sarah Parackal, Sridevi Yadavilli, Abdul Mannan, Mika L. Persson, Dilana E. Staudt, Ryan J. Duchatel, Evangeline R. Jackson
All Supplementary Figures and their captions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9e68dc3c6f26e99f51f1fbaa7e5b3a
https://doi.org/10.1158/0008-5472.22892044
https://doi.org/10.1158/0008-5472.22892044
Autor:
Matthew D. Dun, Jason E. Cain, Sabine Mueller, Carl Koschmann, Javad Nazarian, Nicholas A. Vitanza, David D. Eisenstat, Esther Hulleman, Nicolas André, Eddy Pasquier, Samuel Meignan, Andria Rakotomalala, Fatima Valdes-Mora, Yolanda Colino-Sanguino, Martin R. Larsen, Sebastian M. Waszak, Frank Alvaro, Nicholas G. Gottardo, Raelene Endersby, Meegan Howlett, Ron Firestein, Geoff B. McCowage, Dinisha Govender, Jordan R. Hansford, Sumanth Nagabushan, Neevika Manoharan, Bryan Day, Nathan D. Smith, Brett Nixon, David A. Skerrett-Byrne, Adjanie Patabendige, Tyrone S. Beitaki, Holly P. McEwen, Zacary P. Germon, Izac J. Findlay, Alicia M. Douglas, Padraic S. Kearney, Marion Le Grand, W. Samantha N. Jayasekara, Wai Chin Chong, Shaye Game, Sarah Parackal, Sridevi Yadavilli, Abdul Mannan, Mika L. Persson, Dilana E. Staudt, Ryan J. Duchatel, Evangeline R. Jackson
Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the most lethal of childhood cancers. Palliative radiotherapy is the only established treatment, with median patient survival of 9 to 11 months. ONC201 is a DRD2 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2ec734b3b0e0b8ca6a532d4cfa2040
https://doi.org/10.1158/0008-5472.c.6651055.v1
https://doi.org/10.1158/0008-5472.c.6651055.v1
Autor:
Aleks C. Guanizo, Daniel J. Gough, Anette Szczepny, D. Neil Watkins, Quinton Luong, Vinod Ganju, Prudence A. Russell, Jasmine Chen, Daniel J. Garama, Dhilshan Jayasinghe, Chaitanya Inampudi, W. Samantha N. Jayasekara, Jason E. Cain
Publikováno v:
Oncogene. 41:138-145
Small cell lung cancer (SCLC) is an aggressive neuroendocrine cancer characterized by loss of function TP53 and RB1 mutations in addition to mutations in other oncogenes including MYC. Overexpression of MYC together with Trp53 and Rb1 loss in pulmona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2f094694d8d51078a1e42b2b98c4da3
https://doi.org/10.1038/s41388-021-02070-3
https://doi.org/10.1038/s41388-021-02070-3
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-17 (2018)
Clinical Epigenetics
Clinical Epigenetics
Background Different cell types possess different copies of mtDNA to support their specific requirements for cellular metabolism. Cell-specific mtDNA copy numbers are established through cell-specific mtDNA replication during cell differentiation. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f13a2284e7e4865e551f0f3e6dcd972
http://link.springer.com/article/10.1186/s13148-018-0590-0
http://link.springer.com/article/10.1186/s13148-018-0590-0