Zobrazeno 1 - 10
of 23
pro vyhledávání: '"W S Simonet"'
Publikováno v:
Scopus-Elsevier
Alveolar type II cell proliferation occurs after many forms of lung injury and is thought to play a critical role in alveolar epithelial repair. Keratinocyte growth factor/fibroblast growth factor 7 (KGF) has been shown to promote alveolar type II ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376f1cfa4f274d527c1e48e3041bf5bb
https://doi.org/10.1172/jci118250
https://doi.org/10.1172/jci118250
Publikováno v:
Molecular and Cellular Biology. 14:2243-2256
To identify DNA sequence elements from the human apolipoprotein B (apoB) gene required for high-level, correct tissue-specific expression in transgenic mice, we made several constructs that included one or more of the key regulatory elements that wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111ed018897de7d6763781beecddf9e0
https://doi.org/10.1128/mcb.14.4.2243
https://doi.org/10.1128/mcb.14.4.2243
Publikováno v:
Journal of Lipid Research, Vol 35, Iss 3, Pp 408-416 (1994)
Transgenic mouse lines were produced that expressed low levels of a receptor-binding-defective variant of human apolipoprotein (apo) E, apoE(Arg112, Cys142). In transgenic mice, the human apoE was produced only by the kidney, whereas endogenous mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f337cc1fffe6badb5d5a90d58145f825
http://www.sciencedirect.com/science/article/pii/S0022227520411927
http://www.sciencedirect.com/science/article/pii/S0022227520411927
Autor:
Jaijing Wang, S J Lauer, Karl H. Weisgraber, H. V. De Silva, W S Simonet, Robert W. Mahley, J M Taylor
Publikováno v:
Journal of Biological Chemistry. 269:2324-2335
Overexpression of human apolipoprotein (apo) C-III in the plasma of transgenic mice results in hypertriglyceridemia, with up to a 20-fold elevation in plasma triglyceride. Nearly all of the triglyceride accumulates in the d < 1.006 g/ml lipoprotein f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17c286e0d843630ce72dcc8c76c4e710
https://doi.org/10.1016/s0021-9258(17)42171-5
https://doi.org/10.1016/s0021-9258(17)42171-5
Publikováno v:
Journal of Biological Chemistry. 268:8221-8229
The human apolipoprotein (apo) E and apoC-I genes are located 5 kilobases apart in the same transcriptional orientation on chromosome 19, and they are expressed at high levels in the liver with lower levels of expression in selected other tissues. An
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fce03a91f97770de7a2a695194b2bd2
https://doi.org/10.1016/s0021-9258(18)53085-4
https://doi.org/10.1016/s0021-9258(18)53085-4
Publikováno v:
Journal of Biological Chemistry. 266:8651-8654
To investigate the mechanisms controlling tissue-specific expression of the human apolipoprotein (apo) E/C-I gene locus, human apoE and apoC-I gene constructs containing various lengths of the 5'-flanking or 3'-flanking region were used to create tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::689b1c0e23c374ce8e03079f8939e367
https://doi.org/10.1016/s0021-9258(18)31491-1
https://doi.org/10.1016/s0021-9258(18)31491-1
Autor:
D O Wirak, Karl H. Weisgraber, Robert E. Pitas, J M Taylor, M E Stevens, S J Lauer, N Bucay, W S Simonet
Publikováno v:
Journal of Biological Chemistry. 265:10809-10812
Human apolipoprotein (apo) E gene constructs with 30 or 5 kilobases of 5'-flanking and 1.5 kilobases of 3'-flanking regions were used to create transgenic mice. High levels of human apoE mRNA were present in the transgenic kidney, but none was detect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b53bbb5055a801198433bd791a55ee2
https://doi.org/10.1016/s0021-9258(19)38516-3
https://doi.org/10.1016/s0021-9258(19)38516-3
Autor:
R R, Deterding, A M, Havill, T, Yano, S C, Middleton, C R, Jacoby, J M, Shannon, W S, Simonet, R J, Mason
Publikováno v:
Proceedings of the Association of American Physicians. 109(3)
Intratracheal instillation of bleomycin produces pulmonary fibrosis in rats. Alveolar type II cell proliferation is thought to minimize the fibrotic response after lung injury. Because keratinocyte growth factor (KGF) stimulates type II cell prolifer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a2b6724cb4ea787d7d4436ba969722e
https://pubmed.ncbi.nlm.nih.gov/9154642
https://pubmed.ncbi.nlm.nih.gov/9154642
Autor:
W S Simonet, Assumpció Bosch, Beverly L. Davidson, S M Chang, Douglas J. Jolly, T R Ulich, Paul B. McCray
Publikováno v:
The Journal of clinical investigation. 98(12)
Retroviral gene transfer to liver without prior injury has not yet been accomplished. We hypothesized that recombinant human keratinocyte growth factor would stimulate proliferation of hepatocytes and allow for efficient in vivo gene transfer with hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63395050729c31d407a7114853fa438d
https://pubmed.ncbi.nlm.nih.gov/8981911
https://pubmed.ncbi.nlm.nih.gov/8981911
Publikováno v:
Scopus-Elsevier
Keratinocyte growth factor (KGF) caused cystic dilation of mouse fetal lung explants in vitro, markedly increasing the luminal volume of lung buds and disrupting branching morphogenesis. Effects of KGF were dose dependent, were detected within 4 h of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0553cfacd7db8fdc4a545cab59a3ec50
https://pubmed.ncbi.nlm.nih.gov/8997270
https://pubmed.ncbi.nlm.nih.gov/8997270