Zobrazeno 1 - 7
of 7
pro vyhledávání: '"W S Fillers"'
Publikováno v:
Journal of Applied Physiology. 77:2086-2092
Inhibition or activation of cellular function due to acute decreases in PO2 can be considered in terms of two different processes: 1) a sensor that monitors PO2 decreases and 2) transduction systems directed from the O2 sensor to reactions that contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b333718b5fa644d189554e22637faafd
https://doi.org/10.1152/jappl.1994.77.5.2086
https://doi.org/10.1152/jappl.1994.77.5.2086
Autor:
T D, Aicher, R C, Anderson, J, Gao, S S, Shetty, G M, Coppola, J L, Stanton, D C, Knorr, D M, Sperbeck, L J, Brand, C C, Vinluan, E L, Kaplan, C J, Dragland, H C, Tomaselli, A, Islam, R J, Lozito, X, Liu, W M, Maniara, W S, Fillers, D, DelGrande, R E, Walter, W R, Mann
Publikováno v:
Journal of medicinal chemistry. 43(2)
N'-methyl-N-(4-tert-butyl-1,2,5,6-tetrahydropyridine)thiourea, SDZ048-619 (1), is a modest inhibitor (IC(50) = 180 microM) of pyruvate dehydrogenase kinase (PDHK). In an optimization of the N-methylcarbothioamide moiety of 1, it was discovered that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b1772832e8ae976302ee3c02cf1e34f5
https://pubmed.ncbi.nlm.nih.gov/10649979
https://pubmed.ncbi.nlm.nih.gov/10649979
Autor:
W. S. Fillers, D. K. Cohen, D. T. Chu, K. Bürki, D. A. Young, Joseph L. Evans, R. W. Deacon, R. O. Deems, C. M. Honer
Publikováno v:
Diabetologia. 37(11)
Glucose metabolism was evaluated in transgenic mice expressing the human GLUT 4 glucose transporter. Fed GLUT 4 transgenic mice exhibited a 32% and 56% reduction in serum glucose and insulin and a 69% and 33% increase in non-esterified fatty acid and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6058ceb03dbc8c70dd4afdc5473d0065
https://pubmed.ncbi.nlm.nih.gov/7867881
https://pubmed.ncbi.nlm.nih.gov/7867881
Publikováno v:
Journal of Biological Chemistry. 255:10033-10035
The protomeric form of purified acetyl coenzyme A carboxylase is inactivated by the binding of avidin to the biotinyl prosthetic group; the catalytically active filamentous form of the enzyme is resistant to avidin. This differential sensitivity to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::199ff354dd10788dab97fdeda388e8aa
https://doi.org/10.1016/s0021-9258(19)70420-7
https://doi.org/10.1016/s0021-9258(19)70420-7
Publikováno v:
Progress in clinical and biological research. 219
Actomyosin in smooth muscle is in a quiescent state. The mechanism or mechanisms by which Ca2+ activates the actomyosin ATPase is not clear. There is sufficient evidence for the presence of enzyme systems which phosphorylate and dephosphorylate myosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85087dcaf97a83be4dc7c123c0740e2d
https://pubmed.ncbi.nlm.nih.gov/2947244
https://pubmed.ncbi.nlm.nih.gov/2947244
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 85(19)
High levels of phosphocreatine, a compound known to serve as an intracellular energy reserve, were found in the fluid contained in seminal vesicle glands. The concentrations of phosphocreatine in the extracellular fluid in the mouse and rat were foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633d5184fced2c7c437fa6643c8a623a
https://pubmed.ncbi.nlm.nih.gov/3174632
https://pubmed.ncbi.nlm.nih.gov/3174632
Autor:
R F, Coburn, W S, Fillers
Publikováno v:
Progress in clinical and biological research. 315
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f6c95fe9fac1aa6cba90dbff64f63df7
https://pubmed.ncbi.nlm.nih.gov/2678157
https://pubmed.ncbi.nlm.nih.gov/2678157