Zobrazeno 1 - 10
of 14
pro vyhledávání: '"W S, Samowitz"'
Publikováno v:
The American Journal of Gastroenterology. 96:1927-1929
Dermatitis herpetiformis is associated with a gluten-sensitive enteropathy in85% of cases. Both the skin lesions and the enteropathy respond to gluten restriction. Linear IgA bullous dermatosis has a much lower prevalence of histological small bowel
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 10(9)
Some previous studies have reported an improved prognosis in sporadic colon cancers with microsatellite instability, whereas others have not. In addition, relatively few of those reporting an improved prognosis controlled for tumor stage or were popu
Autor:
M L, Slattery, J D, Potter, K, Curtin, S, Edwards, K N, Ma, K, Anderson, D, Schaffer, W S, Samowitz
Publikováno v:
Cancer research. 61(1)
There are sex differences in the occurrence of microsatellite instability (MSI) in colon tumors. Taken together with the epidemiological evidence that hormone replacement therapy (HRT) and, less consistently, parity, are inversely associated with col
Autor:
M L, Slattery, K, Curtin, K, Anderson, K N, Ma, S, Edwards, M, Leppert, J, Potter, D, Schaffer, W S, Samowitz
Publikováno v:
Cancer research. 60(24)
Ki-ras mutations are thought to be early events in the carcinogenic process leading to colon tumors. Dietary factors associated with colon cancer may be associated with these mutations. Data from a population-based, multicenter, case-control study of
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 9(11)
Some previous studies have demonstrated significant results between Ki-ras mutations and tumor stage, survival, and/or other clinical variables, whereas others have not. We therefore evaluated the significance of codons 12 and 13 Ki-ras mutations in
Autor:
W S, Samowitz, M L, Slattery
Publikováno v:
Genes, chromosomescancer. 26(2)
The reproducibility of microsatellite instability from different regions of the same sporadic colon cancer has not been addressed. We therefore microdissected and extracted DNA from three to nine separate regions of 13 highly unstable sporadic colon
Publikováno v:
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 12(4)
New anticancer drugs targeting DNA topoisomerase I (Topo I) are now approved for clinical use for the treatment of colon cancer. From laboratory work, it is known that tumors cells with high Topo I are sensitive to these drugs and that tumor cells wi
Publikováno v:
Cancer research. 59(7)
Loss of serine or threonine phosphorylation sites from exon 3 of beta-catenin has been identified in approximately half of colorectal tumors which lack adenomatous polyposis coli (APC) mutations, but the overall contribution of beta-catenin mutations
Autor:
W S, Samowitz, M L, Slattery
Publikováno v:
The American journal of pathology. 151(1)
Frame-shift mutations in a run of 10 adenines (A10) of the transforming growth factor-beta receptor type 2 gene (TGF-beta RII) are commonly seen in inherited and sporadic colonic cancers that exhibit microsatellite instability. A10 mutations and inst
Publikováno v:
Cancer research. 55(17)
Reverse transcription-PCR combined with either (a) restriction enzyme digestion and repeat PCR or (b) ligase chain reaction has identified two new alternatively spliced transcripts of the adenomatous polyposis coli (APC) gene. In one of these transcr