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Covalently closed circular viral DNA formed from two types of linear DNA in woodchuck hepatitis virus-infected liver

Autor: Wengang Yang, Jesse Summers, W S Mason

Publikováno v: Journal of Virology. 70:4567-4575

We found that livers from woodchucks chronically infected with woodchuck hepatitis virus (WHV) contained covalently closed circular DNA (cccDNA) molecules with deletions and insertions indicative of their formation from linear viral DNA by nonhomolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72f236afb94590f9296749a9db9f9a1
https://doi.org/10.1128/jvi.70.7.4567-4575.1996

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Geographic variation in viral load among hepatitis B carriers with differing risks of hepatocellular carcinoma

Autor: A A, Evans, A P, O'Connell, J C, Pugh, W S, Mason, F M, Shen, G C, Chen, W Y, Lin, A, Dia, S, M'Boup, B, Dramé, W T, London

Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 7(7)

The risk of hepatocellular carcinoma (HCC) varies significantly among hepatitis B virus (HBV) carriers from different geographic regions. We compared serological markers of HBV infection in adult male carriers from Haimen City, China and Senegal, Wes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ce8cc8042fd30c7cfe557012bda07bcd
https://pubmed.ncbi.nlm.nih.gov/9681522

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Metabolism in human cells of the D and L enantiomers of the carbocyclic analog of 2'-deoxyguanosine: substrate activity with deoxycytidine kinase, mitochondrial deoxyguanosine kinase, and 5'-nucleotidase

Autor: L L, Bennett, P W, Allan, G, Arnett, Y F, Shealy, D S, Shewach, W S, Mason, I, Fourel, W B, Parker

Publikováno v: Antimicrobial agents and chemotherapy. 42(5)

The carbocyclic analog of 2′-deoxyguanosine (CdG) has broad-spectrum antiviral activity. Because of recent observations with other nucleoside analogs that biological activity may be associated the l enantiomer rather than, as expected, with the d e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2c1d460c90ec98ab1dc74582ac64f241
https://pubmed.ncbi.nlm.nih.gov/9593124

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Characterization of the antiviral effects of 2' carbodeoxyguanosine in ducks chronically infected with duck hepatitis B virus

Autor: W S, Mason, J, Cullen, J, Saputelli, T T, Wu, C, Liu, W T, London, E, Lustbader, P, Schaffer, A P, O'Connell, I, Fourel

Publikováno v: Hepatology (Baltimore, Md.). 19(2)

This study was carried out to evaluate benefits and limitations of long-term therapy of hepatitis B virus infections with a nucleoside analog inhibitor of virus replication. The model we used was the domestic duck chronically infected with duck hepat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::945fd2e935f9f1b01ee207edf2d653eb
https://pubmed.ncbi.nlm.nih.gov/8294097

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A technique for liver biopsy performed in Pekin ducks using anesthesia with Telazol

Autor: N Z, Carp, J, Saputelli, T C, Halbherr, W S, Mason, A R, Jilbert

Publikováno v: Laboratory animal science. 41(5)

Infection of Pekin ducks with duck hepatitis B virus is a useful model for studying the hepadenoviruses, of which human hepatitis B virus is the prototype. The utility of this model has been limited, however, by the difficulties associated with anest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::65ffc1e0321d9af70af13377f5d309d2
https://pubmed.ncbi.nlm.nih.gov/1666151

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Viral DNA synthesis

Autor: C, Seeger, J, Summers, W S, Mason

Publikováno v: Current topics in microbiology and immunology. 168

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e0b4a067cff74d5262f72fb491fd9569
https://pubmed.ncbi.nlm.nih.gov/1893778

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Chronic hepadnavirus infections

Autor: W S, Mason, J, Summers, C, Liu, L C, Condreay, T T, Wu

Publikováno v: Progress in clinical and biological research. 364

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::23484d7ee54c047adbd3d2427b784c01
https://pubmed.ncbi.nlm.nih.gov/2020700

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Expression of endogenous retroviral envelope antigen in Ig(+) B cells of immunized 15I5 X 71 chickens

Autor: M S Halpern, W S Mason, D L Ewert, D T Deery, J M England

Publikováno v: The Journal of Immunology. 126:1198-1202

In a previous study (1), we observed that antigen cross-reactive with structural protein of the endogenous retrovirus RAV-O is expressed in splenic Ig(+) B lymphocytes of immunized 15I5 X 71 chickens. The present experiments were undertaken to determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::194e8cc0003af487e80729202f882bce
https://doi.org/10.4049/jimmunol.126.3.1198

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