Zobrazeno 1 - 10 of 26 pro vyhledávání: '"W S, Head"'
1
Advances in the Management of Keratomycosis and Acanthamoeba Keratitis
Autor: Denis M. O'Day, W. S. Head
Publikováno v: Cornea. 19:681-687
PURPOSE In the late 1960s, the management of fungal keratitis was a serious unresolved problem. Little was known of the epidemiology of the disease, and there were no antifungal agents formulated for use in the eye. METHODS A thorough review of the l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78443b91a00a66a980582bc5d0e2167
https://doi.org/10.1097/00003226-200009000-00013
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2
Defects in beta cell Ca2+ signalling, glucose metabolism and insulin secretion in a murine model of KATP channel-induced neonatal diabetes mellitus
Autor: W. S. Head, Richard K.P. Benninger, David W. Piston, M. S. Remedi, Alessandro Ustione, C. G. Nichols
Mutations that render ATP-sensitive potassium (K(ATP)) channels insensitive to ATP inhibition cause neonatal diabetes mellitus. In mice, these mutations cause insulin secretion to be lost initially and, as the disease progresses, beta cell mass and i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b746bedabfbcc653cb9deb12594ba57
https://europepmc.org/articles/PMC3245714/
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3
Toxicity and Pharmacokinetics of Subconjunctival Amphotericin B
Autor: W S Head, R D Robinson, J B Stevens, Denis M. O'Day, Trilby E. Williams, Richard S. Smith
Publikováno v: Cornea. 10:411-417
The pharmacokinetics and toxicity of subconjunctival (S/C) amphotericin B (AmB) were evaluated in Dutch-belted rabbits. Following the S/C injection of 1,500 micrograms of AmB, corneal and aqueous levels were determined by bioassay. The highest levels
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f014d2480bb917a0955158e4b23351
https://doi.org/10.1097/00003226-199109000-00010
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5
Differences in virulence between two Candida albicans strains in experimental keratitis
Autor: D M, O'Day, W S, Head, C, Csank, D J, Shetlar, R D, Robinson, G W, McCollum, R, Yang, T L, Zhu, M X, Wang
Publikováno v: Investigative ophthalmologyvisual science. 41(5)
To study the differences in disease caused by two wild-type strains of Candida albicans in a model of contact lens-facilitated keratitis in rabbits.Two strains, SC5314 and VE175, were examined. Standardized inocula were placed on the debrided corneal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bf60ad5c8ad691016798449c38129e67
https://pubmed.ncbi.nlm.nih.gov/10752949
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6
Identification and characterization of TUP1-regulated genes in Candida albicans
Autor: M X Wang, Alexander D. Johnson, W S Head, Burkhard R. Braun
Publikováno v: Genetics. 156(1)
TUP1 encodes a transcriptional repressor that negatively controls filamentous growth in Candida albicans. Using subtractive hybridization, we identified six genes, termed repressed by TUP1 (RBT), whose expression is regulated by TUP1. One of the gene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe2dd8ea8216faadf8b7a4f8a17938a
https://pubmed.ncbi.nlm.nih.gov/10978273
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7
Contact lens-induced infection--a new model of Candida albicans keratitis
Autor: D M, O'Day, W S, Head, R D, Robinson, R, Yang, D, Shetlar, M X, Wang
Publikováno v: Investigative ophthalmologyvisual science. 40(7)
A model of experimental keratomycosis was established that mimics human disease in which the only fungi present are those that are actively growing within the cornea.Dutch-belted rabbits received a subconjunctival injection of triamcinolone acetonide
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e26656d99056d16849a301dd6e38177f
https://pubmed.ncbi.nlm.nih.gov/10359345
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8
Development of a chitin assay for the quantification of fungus
Autor: T. N. Oeltmann, C. A. Lamps, R. A. Logan, W S Head, Collins Mj, Denis M. O'Day, R D Robinson
Publikováno v: Current eye research. 14(8)
Chitin, a unique structural polysaccharide found in fungi and arthropods, is not produced by vertebrates. Thus, the potential applications of a specific and sensitive assay for chitin are numerous, including the evaluation of the extent of fungal ker
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49925a9a50a96231a572485822b3a9c
https://pubmed.ncbi.nlm.nih.gov/8529398
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10
The qualitative evaluation of the pharmacokinetics of subconjunctivally injected antifungal agents in rabbits
Autor: Klippenstein K, Denis M. O'Day, Trilby E. Williams, W S Head, R D Robinson
Publikováno v: Cornea. 12(6)
Dutch-belted rabbits with corneal epithelium either intact or debrided were injected subconjunctivally with 300 microliters of one of six antifungal agents: 10 mg/ml miconazole, 5 mg/ml fluconazole, 5 mg/ml ketoconazole, 2.5 mg/ml itraconazole, and 5
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a737d0c406be2e48fc05afe6ecda552a
https://pubmed.ncbi.nlm.nih.gov/8261783
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