Zobrazeno 1 - 10
of 87
pro vyhledávání: '"W Robert McMaster"'
Autor:
David Kepplinger, Mandeep Takhar, Mayu Sasaki, Zsuzsanna Hollander, Derek Smith, Bruce McManus, W Robert McMaster, Raymond T Ng, Gabriela V Cohen Freue
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177569 (2017)
The quantitation of proteins using shotgun proteomics has gained popularity in the last decades, simplifying sample handling procedures, removing extensive protein separation steps and achieving a relatively high throughput readout. The process start
Externí odkaz:
https://doaj.org/article/71bcec8c27484104afa466ea464ed7ac
Autor:
Pierre-André Casgrain, Caroline Martel, W Robert McMaster, Jeremy C Mottram, Martin Olivier, Albert Descoteaux
Publikováno v:
PLoS Pathogens, Vol 12, Iss 5, p e1005658 (2016)
Cysteine peptidases play a central role in the biology of Leishmania. In this work, we sought to further elucidate the mechanism(s) by which the cysteine peptidase CPB contributes to L. mexicana virulence and whether CPB participates in the formation
Externí odkaz:
https://doaj.org/article/8a92e242a4f14252aae9a60c7ff707a4
Autor:
Amandine Isnard, Jan G Christian, Mohamed Kodiha, Ursula Stochaj, W Robert McMaster, Martin Olivier
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004776 (2015)
The protease GP63 is an important virulence factor of Leishmania parasites. We previously showed that GP63 reaches the perinuclear area of host macrophages and that it directly modifies nuclear translocation of the transcription factors NF-κB and AP
Externí odkaz:
https://doaj.org/article/d2e531d0d2b3498f97974dde6f2898e2
Autor:
Alexandra K Marr, Julia L MacIsaac, Ruiwei Jiang, Adriana M Airo, Michael S Kobor, W Robert McMaster
Publikováno v:
PLoS Pathogens, Vol 10, Iss 10, p e1004419 (2014)
Infection of macrophages by the intracellular protozoan Leishmania leads to down-regulation of a number of macrophage innate host defense mechanisms, thereby allowing parasite survival and replication. The underlying molecular mechanisms involved rem
Externí odkaz:
https://doaj.org/article/ee44871f10d64f0ebcca5ebacb35e1bb
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 5, p e2785 (2014)
Leishmaniasis is a major health problem in some endemic areas and yet, no vaccine is available against any form of the disease. Historically, leishmanization (LZ) which is an inoculation of individual with live Leishmania, is the most effective contr
Externí odkaz:
https://doaj.org/article/386cbc88288c46ecb4c891557063e24b
Autor:
Gabriela V Cohen Freue, Anna Meredith, Derek Smith, Axel Bergman, Mayu Sasaki, Karen K Y Lam, Zsuzsanna Hollander, Nina Opushneva, Mandeep Takhar, David Lin, Janet Wilson-McManus, Robert Balshaw, Paul A Keown, Christoph H Borchers, Bruce McManus, Raymond T Ng, W Robert McMaster, Biomarkers in Transplantation and the NCE CECR Prevention of Organ Failure Centre of Excellence Teams
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 4, p e1002963 (2013)
Recent technical advances in the field of quantitative proteomics have stimulated a large number of biomarker discovery studies of various diseases, providing avenues for new treatments and diagnostics. However, inherent challenges have limited the s
Externí odkaz:
https://doaj.org/article/6bda563f480e4d239955d6a664541f26
Autor:
Miriam A Lynn, Jason Kindrachuk, Alexandra K Marr, Håvard Jenssen, Nelly Panté, Melissa R Elliott, Scott Napper, Robert E Hancock, W Robert McMaster
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 5, Iss 5, p e1141 (2011)
Protozoan parasites, such as Leishmania, still pose an enormous public health problem in many countries throughout the world. Current measures are outdated and have some associated drug resistance, prompting the search into novel therapies. Several i
Externí odkaz:
https://doaj.org/article/3adc307bd3a247b38435df30043617b3
Autor:
Sara Kreim, Kirsten Marchand, Emilie Mallia, Richard Dubras, W. Robert McMaster, Karen Tee, Steve Mathias, Skye Barbic
Publikováno v:
Journal of Substance Use and Addiction Treatment. :209076
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cae64e5a0b8f196e1087a5292c8d1f7
https://doi.org/10.1016/j.josat.2023.209076
https://doi.org/10.1016/j.josat.2023.209076
Autor:
W. Robert McMaster, Scott J. Tebbutt, Casey P. Shannon, Gordon Ritchie, Virginia Chen, Ji-Young V. Kim, Bruce M. McManus, Brandon Lee, Raymond T. Ng, Karen Lam, Janet Wilson McManus, Zsuzsanna Hollander, Pavlos G. Koitsopoulos, Sara Assadian
Publikováno v:
Clinical Chemistry. 66:1063-1071
Background HEARTBiT is a whole blood-based gene profiling assay using the nucleic acid counting NanoString technology for the exclusionary diagnosis of acute cellular rejection in heart transplant patients. The HEARTBiT score measures the risk of acu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d2b3f4c55792d18d6da2b346cbf0ee
https://doi.org/10.1093/clinchem/hvaa123
https://doi.org/10.1093/clinchem/hvaa123
Autor:
Raymond T. Ng, Diego H. Delgado, Janet E. Wilson McManus, Robert Balshaw, Shelley Zieroth, W. Robert McMaster, Alice Mui, Michel White, Sara Assadian, Andrew Ignaszewski, Marek Zarzycki, Jenny Öhman, Scott J. Tebbutt, Casey P. Shannon, Debra Isaac, J. Gustav Smith, Ji Young V. Kim, Karen K. Lam, Virginia Chen, Ross A. Davies, Paul Keown, Haissam Haddad, Young Woong Kim, Olof Gidlöf, Daniel Kim, Darlene L.Y. Dai, Bruce M. McManus, Zsuzsanna Hollander, Lori J. West, Mustafa Toma, Miroslaw Rajda
Publikováno v:
The Canadian journal of cardiology. 36(8)
Background Nine mRNA transcripts associated with acute cellular rejection (ACR) in previous microarray studies were ported to the clinically amenable NanoString nCounter platform. Here we report the diagnostic performance of the resulting blood test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32050211f084d0eca9b7da4e19187e5e
https://pubmed.ncbi.nlm.nih.gov/32553816
https://pubmed.ncbi.nlm.nih.gov/32553816