Zobrazeno 1 - 10
of 16
pro vyhledávání: '"W R Baumbach"'
Autor:
B Johnson, Charles E. Lyons, J R Zysk, Bruce D. Gaylinn, Michael O. Thorner, W R Baumbach, Cecil Mark Eppler
Publikováno v:
Biochemical and Biophysical Research Communications. 221:133-139
The receptor for growth hormone-releasing hormone (GHRH) has been purified from bovine pituitary tissue and HEK293 cells transfected with human or porcine receptor using a retrievable biotinylated GHRH analog. Custom synthesized [His1, Nle27, Biotin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed00623c2e472dc1571913f4f7f1dc3c
https://doi.org/10.1006/bbrc.1996.0540
https://doi.org/10.1006/bbrc.1996.0540
Publikováno v:
Scopus-Elsevier
Thyroid hormones inhibit the synthesis and release of GH in avian species. This may represent a feedback mechanism, since GH enhances the peripheral production of tri-iodothyronine (T3). The possibility that GH may also have direct effects on thyroid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4853ba21f9aa16d1ad2019afc498b907
https://doi.org/10.1677/joe.0.1460449
https://doi.org/10.1677/joe.0.1460449
Autor:
Ross Barnard, W. R. Baumbach, E. Peters, William J. Millard, Ken K. Y. Ho, I. Markus, Kin-Chuen Leung
Publikováno v:
Endocrinology. 136:379-385
We have developed a ligand immunofunctional assay (LIFA) for quantifying the circulating functional GH-binding protein (GHBP) in the rat. This two-site solid-phase assay uses a capture monoclonal antibody (4.3) specific to the hydrophilic C-terminal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533c50e9044197ba4b0b39153f5173cc
https://doi.org/10.1210/endo.136.2.7835268
https://doi.org/10.1210/endo.136.2.7835268
Publikováno v:
Endocrinology. 130:3057-3065
In the rat a GH-binding protein (GHBP) exists that is derived from the GH receptor gene by an alternative messenger RNA splicing mechanism such that the transmembrane and intracellular domains of the GH receptor are replaced by a hydrophilic carboxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43049ea9f4aa457aba26d6aa52175d56
https://doi.org/10.1210/endo.130.5.1374020
https://doi.org/10.1210/endo.130.5.1374020
Autor:
J R, Zysk, W R, Baumbach
Publikováno v:
Combinatorial chemistryhigh throughput screening. 1(4)
The development of high throughput, homogeneous pharmacologic and functional assays and their implementation in screening combinatorial libraries has increased the pace of stochastic drug discovery in recent years. New, noninvasive approaches involvi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a1af6d18f2d5d79f42cb2082c188d194
https://pubmed.ncbi.nlm.nih.gov/10499123
https://pubmed.ncbi.nlm.nih.gov/10499123
Publikováno v:
Growth regulation. 6(3)
The presence of growth hormone (GH) receptor (GHR) gene transcripts and GH-binding sites in guinea pig liver suggests normal expression and translation of a GHR gene in these animals. Guinea pigs are, however, resistant to GH action and appear to lac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4e417b77f7284c94ca30ef71bc05e874
https://pubmed.ncbi.nlm.nih.gov/8894650
https://pubmed.ncbi.nlm.nih.gov/8894650
Autor:
R, Barnard, J, Mulcahy, J, García-Aragón, B, Wyse, P C, Owens, S W, Rowlinson, F, Talamantes, W R, Baumbach, M J, Waters
Publikováno v:
Growth regulation. 4(4)
A radioimmunoassay (RIA) for the rat growth hormone binding protein (GHBP) was developed using a synthetic peptide (corresponding to the hydrophilic carboxyl-terminal sequence of mouse GHBP) as standard and a monoclonal antibody (MAb 4.3) reactive wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d44dc09dbda338b502f6a43c65ba6099
https://pubmed.ncbi.nlm.nih.gov/7756972
https://pubmed.ncbi.nlm.nih.gov/7756972
Publikováno v:
Endocrinology. 133(3)
GH receptor immunoreactivity is widely distributed within the rat pituitary gland, although apart from somatotrophs the cell types with GH receptor immunoreactivity have yet to be identified. It is also unknown whether this immunoreactivity reflects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba67bc54ec7733f638be7f24b2ffa87
https://pubmed.ncbi.nlm.nih.gov/8396011
https://pubmed.ncbi.nlm.nih.gov/8396011
Publikováno v:
Endocrinology. 132(3)
While circulating GH concentrations are high in fetal life, skeletal growth is only slightly reduced by GH deficiency in utero. This has been explained by the relatively low binding of GH to fetal hepatic tissue, suggesting a lack of GH receptors (GH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4279ebe55f309ff66e7c432d0928f8f0
https://pubmed.ncbi.nlm.nih.gov/8440172
https://pubmed.ncbi.nlm.nih.gov/8440172
Publikováno v:
Oncogene. 5(10)
These studies were initiated as an attempt to estimate the number and nature of genetic changes that are required in addition to c-myc deregulation during monocyte tumorigenesis, and to determine whether the oncogenic changes that can be created in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::58f324dbc7fad5d1b6e3cdcdb0bcf7ea
https://pubmed.ncbi.nlm.nih.gov/2250911
https://pubmed.ncbi.nlm.nih.gov/2250911