Zobrazeno 1 - 10
of 49
pro vyhledávání: '"W R, McMaster"'
Autor:
Akram Miramin Mohammadi, Liv Eidsmo, Thorsten Lieke, Susanne Nylén, Hannah Akuffo, Louise Berg, W. R. McMaster, Ali Khamesipour
Publikováno v:
Clinical and Experimental Immunology. 153:221-230
SummaryNatural killer (NK) cells contribute to immunity as the first line of defence in numerous infections by early cytokine secretion and cytotoxicity. In Leishmania infection, NK cells contribute with interferon-γ and may assist in directing the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f64a7d084acd73c17cce8f17641660
https://doi.org/10.1111/j.1365-2249.2008.03687.x
https://doi.org/10.1111/j.1365-2249.2008.03687.x
Publikováno v:
Experimental Parasitology. 100:44-53
The protozoan parasite Leishmania has a digenetic life cycle, alternating between the promastigote and the amastigote stages. Amastigotes infect macrophage cells and reside in the hydrolytic environment of the phagolysosome. Leishmania show distinct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f256363da06b0e5b19ed6078f86159
https://doi.org/10.1006/expr.2001.4677
https://doi.org/10.1006/expr.2001.4677
Publikováno v:
Scandinavian Journal of Immunology. 54:414-420
Objectives of this study were to test the cytokine gene expression in peripheral blood mononuclear cells (PBMCs) from cases with nonhealing and healing cutaneous leishmaniasis (CL) in response to in vitro stimulation of recombinant gp63 (rgp63) and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b21f2195b0da95a3e075d3cfa27cbdba
https://doi.org/10.1046/j.1365-3083.2001.00990.x
https://doi.org/10.1046/j.1365-3083.2001.00990.x
Autor:
Anne Dell, W R McMaster, Charlotte J. Morrison, Richard L. Easton, Howard R. Morris, James M. Piret
Publikováno v:
Biotechnology and Bioengineering. 68:407-421
The N-linked glycans of recombinant leishmanolysin (GP63) expressed as a glycosylphosphatidylinositol (GPI)-anchored membrane protein or modified for secretion in Chinese hamster ovary (CHO) cells were analyzed by fast atom bombardment-mass spectrome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81b66cd78c7895ef7613166b4447f88f
https://doi.org/10.1002/(sici)1097-0290(20000520)68:4<407::aid-bit6>3.0.co
https://doi.org/10.1002/(sici)1097-0290(20000520)68:4<407::aid-bit6>3.0.co
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1253:199-207
The major surface glycoprotein of Leishmania promastigotes, referred to as GP63, is a zinc metalloproteinase of 63 000 Mr containing a glycosylphosphatidylinositol (GPI) membrane anchor. Recent studies demonstrated that recombinant GP63 (rGP63) expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3128a0e67a3ca374f0ee9816b6bfc9
https://doi.org/10.1016/0167-4838(95)00155-5
https://doi.org/10.1016/0167-4838(95)00155-5
Autor:
Charlotte J. Morrison, Andrew Brittingham, K P Chang, David M. Mosser, W R McMaster, B.S. McGwire
Publikováno v:
The Journal of Immunology. 155:3102-3111
The Leishmania surface protease gp63 has been identified as a parasite virulence factor. To better define the role of gp63 in Leishmania infectivity, the interaction of recombinant gp63 with complement and complement receptors was examined. On Leishm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4e87c5d320dff02d4a057fa5b10774
https://doi.org/10.4049/jimmunol.155.6.3102
https://doi.org/10.4049/jimmunol.155.6.3102
Publikováno v:
Experimental Parasitology. 78:161-174
Proteins containing tandemly repeating peptide sequences are characteristic of several parasite antigens. Previously it was reported that Leishmania major contain two genes, Lm20 and Lm39, consisting of two unrelated repeat sequences of 42 and 30 bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92551b2a241a5fcc7eb130866b6d6faa
https://doi.org/10.1006/expr.1994.1016
https://doi.org/10.1006/expr.1994.1016
Publikováno v:
Parasitology. 108:S29-S36
SUMMARYThe major surface glycoprotein ofLeishmania, referred to as GP63, is a zinc metalloproteinase of 63000Mrpresent on promastigotes and amastigotes from diverse species ofLeishmania. GP63 shares several characteristics with the members of the mat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4264f622f3c39954c4ef4c78afe44bfb
https://doi.org/10.1017/s0031182000075697
https://doi.org/10.1017/s0031182000075697
Publikováno v:
Gene. 134:75-81
A gene encoding the Leishmania surface metalloproteinase, GP63, was modified using the polymerase chain reaction to obtain effective secretion of recombinant GP63 (reGP63) in the baculovirus insect cell expression system. The coding region for the N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3ed530b10633149cb6a45d2894a67d
https://doi.org/10.1016/0378-1119(93)90176-4
https://doi.org/10.1016/0378-1119(93)90176-4
Autor:
J R Webb, W R McMaster
Publikováno v:
Journal of Biological Chemistry. 268:13994-14002
The genes encoding GP63, the major surface glycoprotein of the protozoan parasite Leishmania, are highly conserved across diverse species of Leishmania both within the protein coding region and in the immediate 5'-untranslated region. Located between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::418eaeb509c922c42e9a08c2de13882c
https://doi.org/10.1016/s0021-9258(19)85200-6
https://doi.org/10.1016/s0021-9258(19)85200-6