Zobrazeno 1 - 10
of 59
pro vyhledávání: '"W R, McCombie"'
Autor:
Christopher R. Vakoc, Sofya A. Polyanskaya, Olaf Klingbeil, Kenneth Chang, Melissa Kramer, Sara Goodwin, W. R. McCombie, Emily Hodges, Maria E. Figueroa, Emmalee R. Adelman, Zhaolin Yang, Shruti V. Iyer, Sofia Costa, Yiliang Wei, Osama El Demerdash
An enhanced requirement for extracellular nutrients is a hallmark property of cancer cells. Here, we optimized anin vivogenetic screening strategy for evaluating dependencies in acute myeloid leukemia (AML), which led to the identification of the myo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40f1b30ccbdecba7182f867cd80b5a9b
https://doi.org/10.1101/2020.12.22.424018
https://doi.org/10.1101/2020.12.22.424018
Autor:
Xiaosa Xu, Alexander Dobin, Kenneth D. Birnbaum, Thomas R. Gingeras, Peter Van Buren, Michael C. Schatz, Cornel Ghiban, Melissa DelaBastide, Zhenyuan Lu, W. R. McCombie, Jorg Drenkow, Sara Goodwin, Michael Regulski, Carlos Ortiz-Ramírez, Xiaofei Wang, Cristina Fernandez-Marco, David A. Jackson, Robert A. Martienssen, Liya Wang, David A. Micklos, Doreen Ware
Publikováno v:
Frontiers in Plant Science
Frontiers in Plant Science, Vol 11 (2020)
Frontiers in Plant Science, Vol 11 (2020)
MaizeCODE is a project aimed at identifying and analyzing functional elements in the maize genome. In its initial phase, MaizeCODE assayed up to five tissues from four maize strains (B73, NC350, W22, TIL11) by RNA-Seq, Chip-Seq, RAMPAGE, and small RN
MotivationExome sequencing is a powerful technique for the identification of disease-causing genes. A number of Mendelian inherited disease genes have been identified through this method. However, it remains a challenge to leverage exome sequencing f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6885a96a4310efa10ea731c6834890d5
https://doi.org/10.1101/464842
https://doi.org/10.1101/464842
Autor:
Peter P. Zandi, Benjamin N.R. Cheyette, Pierre-Marie Martin, Kimberly A. Mulligan, Shaun Purcell, James B. Potash, Caitlin E. Moyer, Robert E. Stanley, Adam P. Ross, Stephen Sanders, Andiara E. Freitas, Audrey C. Brumback, S. Dominguez, Saul Kivimäe, W. R. McCombie, Mehdi Pirooznia, K. S. Stapornwongkul, Yi Zuo, Vikaas S. Sohal, Jillian Iafrati
Publikováno v:
Molecular psychiatry, vol 23, iss 2
Molecular psychiatry
Molecular psychiatry
Mice lacking DIX domain containing-1 (DIXDC1), an intracellular Wnt/β-catenin signal pathway protein, have abnormal measures of anxiety, depression and social behavior. Pyramidal neurons in these animals' brains have reduced dendritic spines and glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f57a2f67bc852c968f0e7dc37fb84f3
https://escholarship.org/uc/item/0pk9f0px
https://escholarship.org/uc/item/0pk9f0px
Autor:
Megan Crow, Shane McCarthy, Jayon Lihm, Jessica Tollkuhn, W. R. McCombie, Bo Li, Hayan Lee, Jesse Gillis, Sara Ballouz, Sandra Ahrens
Publikováno v:
SSRN Electronic Journal.
Chromatin accessibility provides an important window into the regulation of gene expression. Recently, the Assay of Transposase Accessible Chromatin with sequencing (ATAC-seq) was developed to profile genome-wide chromatin accessibility. In this work
Publikováno v:
Journal of Biosensors & Bioelectronics.
In this study, the enzymatic in situ cutting of linearized DNA molecules at approximately 11 kbp intervals is demonstrated using a soft lithography technique. The ultimate goal is to provide a general ordered cutting method to greatly simplify the as
Autor:
Jayon Lihm, Shane McCarthy, Eric Kelleher, Elena Ghiban, Carol O'Brien, Aiden Corvin, Jesse Gillis, Melissa Kramer, Rebecca Solomon, Seungtai Yoon, Paul Pavlidis, Meeta Mistry, Michael Gill, Derek W. Morris, Eric Antoniou, W R McCombie, Berstein Y, Gary Donohoe
Publikováno v:
Molecular psychiatry
Schizophrenia is a serious psychiatric disorder with a broadly undiscovered genetic etiology. Recent studies of de novo mutations (DNMs) in schizophrenia and autism have reinforced the hypothesis that rare genetic variation contributes to risk. We ca
SummaryLong read sequencing platforms, which include the widely used Pacific Biosciences (PacBio) platform and the emerging Oxford Nanopore platform, aim to produce sequence fragments in excess of 15-20 kilobases, and have proved advantageous in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72c47862722c734f3f72db1478543d0
Autor:
Nuri Kim, Christopher M. Hammell, O Ramos Mendivil, Melissa Kramer, W. R. McCombie, Cristina Aguirre-Chen
One of the primary challenges in the field of psychiatric genetics is the lack of anin vivomodel system in which to functionally validate candidateneuropsychiatricriskgenes (NRGs) in a rapid and cost-effective manner1−3. To overcome this obstacle,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a46d25df07416bd604b8939244add2
Autor:
William Hennah, Dinesh C. Soares, W. R. McCombie, Pippa A. Thomson, Kathryn L. Evans, D. H. Blackwood, Shane McCarthy, Atsushi Kamiya, Akira Sawa, Nicholas J. Brandon, David J. Porteous, Carsten Korth, Steven J. Clapcote, J. C. Roder, Stephen M. Lawrie, J. K. Millar, Andrew M. McIntosh, D. St Clair
Publikováno v:
Molecular Psychiatry. 19:141-143
DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan