Zobrazeno 1 - 10
of 19
pro vyhledávání: '"W R, Kem"'
Publikováno v:
Hydrobiologia. 266:247-254
Autor:
H, Shen, T, Kihara, H, Hongo, X, Wu, W R, Kem, S, Shimohama, A, Akaike, T, Niidome, H, Sugimoto
Publikováno v:
British journal of pharmacology. 161(1)
Glutamate excitotoxicity may be involved in ischaemic injury to the CNS and some neurodegenerative diseases, such as Alzheimer's disease. Donepezil, an acetylcholinesterase (AChE) inhibitor, exerts neuroprotective effects. Here we demonstrated a nove
Publikováno v:
Toxicon : official journal of the International Society on Toxinology. 54(8)
Publikováno v:
Journal of Biological Chemistry. 265:13016-13028
Autor:
T K, Machu, M E, Hamilton, T F, Frye, C L, Shanklin, M C, Harris, H, Sun, T E, Tenner, F S, Soti, W R, Kem
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 299(3)
The nicotinic receptor drug candidate, 3-(2,4-dimethoxybenzylidene)-anabaseine (also known as GTS-21; DMXBA), its hydroxy metabolites, and some related analogs were evaluated with the two-electrode voltage-clamp technique in mouse 5-hydroxytryptamine
Publikováno v:
Biopharmaceuticsdrug disposition. 19(3)
DMXBA (3-(2,4-dimethoxybenzylidene)-anabaseine, also known as GTS-21) is currently being tested as a possible pharmacological treatment of cognitive dysfunction in Alzheimer's disease. In this study, plasma and brain pharmacokinetics as well as urina
Publikováno v:
Japanese journal of pharmacology. 74(2)
Anabaseine is a naturally occurring toxin that stimulates a variety of neuronal and muscle nicotinic receptors. GTS-21 [3-(2,4-dimethoxybenzylidene)anabaseine], an anabaseine derivative, selectively stimulates alpha 7-containing nicotinic receptors.
Publikováno v:
Molecular pharmacology. 47(1)
Investigation of the naturally occurring, nicotinic agonist anabaseine and novel derivatives has shown that these compounds have cytoprotective and memory-enhancing effects. The hypothesis that these arise at least in part through actions on brain ni
Publikováno v:
Behavioral neuroscience. 108(3)
A nicotinic cholinergic antagonist, mecamylamine (MEC), was administered to rabbits tested on eyeblink classical conditioning (EBCC) in the 750-ms delay paradigm for 10 90-trial sessions. Nicotinic receptors were measured in 3 brain regions in 5 trea
Publikováno v:
Peptide research. 3(5)
Monosubstituted analogs of Stichodactyla helianthus neurotoxin I (ShI), a sea anemone polypeptide, were synthesized by solid-phase methods. The analogs were selected to probe the importance of charged residues in the amino-terminal region; ionizable