Zobrazeno 1 - 10
of 18
pro vyhledávání: '"W Prebble"'
Autor:
Darren C. Holland, Dale W. Prebble, Mark J. Calcott, Wayne A. Schroder, Francesca Ferretti, Aaron Lock, Vicky M. Avery, Milton J. Kiefel, Anthony R. Carroll
Publikováno v:
Molecules, Vol 29, Iss 15, p 3648 (2024)
Marine natural products (MNPs) continue to be tested primarily in cellular toxicity assays, both mammalian and microbial, despite most being inactive at concentrations relevant to drug discovery. These MNPs become missed opportunities and represent a
Externí odkaz:
https://doaj.org/article/f89cc53b0fe941b8a953a64e5fcc6f23
Autor:
Dale W. Prebble, Safak Er, Mingming Xu, Irena Hlushchuk, Andrii Domanskyi, Mikko Airavaara, Merrick G. Ekins, George D. Mellick, Anthony R. Carroll
Publikováno v:
Results in Chemistry, Vol 4, Iss , Pp 100472- (2022)
The neuronal protein α-synuclein (α-syn) is one of the main constituents of intracellular amyloid aggregations found in the post-mortem brains of Parkinson’s disease (PD) patients. Recently, we screened the MeOH extracts obtained from 300 sub-tro
Externí odkaz:
https://doaj.org/article/ebdbe234d624481a967c223a4a7ebfda
Autor:
Dale W. Prebble, Tanja M. Voser, Safak Er, Irena Hlushchuk, Andrii Domanskyi, Mikko Airavaara, Merrick G. Ekins, George D. Mellick, Anthony R. Carroll
Publikováno v:
Results in Chemistry, Vol 4, Iss , Pp 100302- (2022)
During a high-throughput screen of 300 Australian marine invertebrate extracts, the extract of the marine sponge Clathria (Thalysias) cf. hesperia was identified with α-synuclein binding activity. The bioassay-guided purification of this extract res
Externí odkaz:
https://doaj.org/article/d9b1edf9ef4c4f8cb9d92ed987c40d02
Autor:
Tanja M. Voser, Joshua B. Hayton, Dale W. Prebble, Ju Jin, Gary Grant, Merrick G. Ekins, Anthony R. Carroll
Publikováno v:
Journal of Natural Products. 86:475-481
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::962cc9c145691360f8804eb7194118fd
https://doi.org/10.1021/acs.jnatprod.2c01125
https://doi.org/10.1021/acs.jnatprod.2c01125
Autor:
Dale W. Prebble, Darren C. Holland, Joshua B. Hayton, Francesca Ferretti, Laurence K. Jennings, Jack Everson, Mingming Xu, Milton J. Kiefel, George D. Mellick, Anthony R. Carroll
Publikováno v:
Journal of Natural Products. 86:533-540
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63413f741f8e61bdcc1db026e26c23aa
https://doi.org/10.1021/acs.jnatprod.2c01140
https://doi.org/10.1021/acs.jnatprod.2c01140
Publikováno v:
Journal of Natural Products. 84:3039-3043
During a recent biodiscovery study to identify new α-synuclein (α-syn) aggregation inhibitors, we screened 29 Australian marine sponge and ascidian extracts in an MS binding assay. This resulted in an extract from the ascidian Sycozoa cerebriformis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::251bf081018e751ae238c5d59c252a64
https://doi.org/10.1021/acs.jnatprod.1c00768
https://doi.org/10.1021/acs.jnatprod.1c00768
Autor:
Marc-André Brideau, Joanna Beresford, W Prebble, Caleb Gasston, David Bevan, James Arthurs, Martin S. Brook
Publikováno v:
New Zealand Journal of Geology and Geophysics. 65:299-314
Overseas, relict deep-seated coastal landslides have attracted significant analysis because of potential hazards caused by sea level rise and climate change. Despite the rapid growth in the Aucklan...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9469e5f2a41757ac8fe9fd3c17e46dc
https://doi.org/10.1080/00288306.2020.1865414
https://doi.org/10.1080/00288306.2020.1865414
Anti-prion and α-Synuclein Aggregation Inhibitory Sterols from the Sponge Lamellodysidea cf. chlorea
Autor:
Dale W Prebble, Mingming Xu, Merrick Ekins, Alan L. Munn, Anthony R. Carroll, George D. Mellick, Laurence K. Jennings
Publikováno v:
Journal of Natural Products. 83:3751-3757
In a study aimed at identifying new anti-prion compounds we screened a library of 500 Australian marine invertebrate derived extracts using a yeast-based anti-prion assay. This resulted in an extract from the subtropical sponge Lamellodysidea cf. chl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65b91129de881a39008c9daccd72b01d
https://doi.org/10.1021/acs.jnatprod.0c01168
https://doi.org/10.1021/acs.jnatprod.0c01168
Publikováno v:
Organic Letters. 22:9574-9578
Citronamine A (1), an isoquinoline alkaloid containing an unprecedented pentacyclic ring system, was isolated from the Australian marine sponge Citronia astra. Based on the combination of MS and NMR analyses and comparison of experimental and TDDFT c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9276f2bd6d0a87864b61a00cdc6b81ea
https://doi.org/10.1021/acs.orglett.0c03633
https://doi.org/10.1021/acs.orglett.0c03633
Autor:
Darren C. Holland, Dale W. Prebble, Safak Er, Joshua B. Hayton, Luke P. Robertson, Vicky M. Avery, Andrii Domanskyi, Milton J. Kiefel, John N. A. Hooper, Anthony R. Carroll
Seven new polyaromatic bis-spiroketal-containing butenolides, the prunolides D–I (4–9) and cis-prunolide C (10), a new dibrominated β-carboline sulfamate named pityriacitrin C (11), alongside the known prunolides A–C (1–3) were isolated from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681d6824f5e2603fe128de32b2198532
http://hdl.handle.net/10138/353211
http://hdl.handle.net/10138/353211
