Výsledky vyhledávání - "W P, Weidanz"

Participation of lymphocyte subpopulations in the pathogenesis of experimental murine cerebral malaria

Autor: D M Yañez, D D Manning, A J Cooley, W P Weidanz, H C van der Heyde

Publikováno v: The Journal of Immunology. 157:1620-1624

We determined the requirement for selected lymphocyte subsets and cytokines in the pathogenesis of experimental murine cerebral malaria (CM) by using gene-targeted knockout and mAb-suppressed mice. Plasmodium berghei ANKA infection induced CM in A 0/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ce159a5d09a76cea168a8df83b0e7f1
https://doi.org/10.4049/jimmunol.157.4.1620

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Gamma delta T cells function in cell-mediated immunity to acute blood-stage Plasmodium chabaudi adami malaria

Autor: H C van der Heyde, M M Elloso, W L Chang, M Kaplan, D D Manning, W P Weidanz

Publikováno v: The Journal of Immunology. 154:3985-3990

To determine whether gamma delta T cells are essential for the resolution of acute Plasmodium chabaudi adami (P. c. adami) malaria, we depleted gamma delta T cells from C57BL/6 mice with hamster monoclonal anti-TCR gamma delta Ab treatment. During th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be4526373608507d731b79b818711e6f
https://doi.org/10.4049/jimmunol.154.8.3985

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Inhibition of Plasmodium falciparum in vitro by human gamma delta T cells

Autor: M M Elloso, H C van der Heyde, J A vande Waa, D D Manning, W P Weidanz

Publikováno v: The Journal of Immunology. 153:1187-1194

As assessed by flow cytometry, human gamma delta T cells were shown here to inhibit replication of blood-stage Plasmodium falciparum in vitro in a dose-dependent fashion; no other leukocyte population tested was suppressive. Replication of intraeryth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb32c14deb703a73b39b76467b720f45
https://doi.org/10.4049/jimmunol.153.3.1187

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The resolution of acute malaria in a definitive model of B cell deficiency, the JHD mouse

Autor: H C van der Heyde, D Huszar, C Woodhouse, D D Manning, W P Weidanz

Publikováno v: The Journal of Immunology. 152:4557-4562

Because the role of cell-mediated immunity (CMI) in the resolution of blood-stage malaria remains unclear, we examined the question of whether mice completely lacking Ab-mediated immunity (AMI) but possessing some CMI can resolve experimental malaria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f26251488a7817f4269b90e5634097f
https://doi.org/10.4049/jimmunol.152.9.4557

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Signalling through the IL-2 receptor γ(c) peptide (CD132) is essential for the expression of immunity to Plasmodium chabaudi adami blood-stage malaria

Autor: W P, Weidanz, G, Lafleur, A, Kita-Yarbro, K, Nelson, J M, Burns

Publikováno v: Parasite immunology. 33(9)

A genetic dissection approach was employed to determine whether the IL-2 receptor complex (IL-2R) comprised of α, β and γ chains is required for the suppression of Plasmodium chabaudi adami parasitemia. Blood-stage infections in IL-2Rγ(c)(-/y) mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f2b8910cdfae3ff40a0db09552a8e57d
https://pubmed.ncbi.nlm.nih.gov/21585397

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Role of CD4+ T cells in the expansion of the CD4-, CD8- gamma delta T cell subset in the spleens of mice during blood-stage malaria

Autor: H C van der Heyde, D D Manning, W P Weidanz

Publikováno v: The Journal of Immunology. 151:6311-6317

The previously observed expansion of the splenic gamma delta T cell subset was examined during the course of murine malaria to determine whether CD4+ T cells are required. Flow cytometric analysis during the course of Plasmodium chabaudi adami malari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2ce0a2cc0b1af470f06f0a9ea6cc4a1
https://doi.org/10.4049/jimmunol.151.11.6311

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Plasticity of immune responses suppressing parasitemia during acute Plasmodium chabaudi malaria

Autor: W P, Weidanz, J R, Kemp, J M, Batchelder, F K, Cigel, M, Sandor, H C, Heyde

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(12)

gammadelta T cells have a crucial role in cell-mediated immunity (CMI) against P. chabaudi malaria, but delta-chain knockout (KO) (deltao/o) mice and mice depleted of gammadelta T cells with mAb cure this infection. To address the question of why mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6994c3ac1205ee9d4edf1538af866bed
https://pubmed.ncbi.nlm.nih.gov/10358190

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Human gamma delta T cell subset-proliferative response to malarial antigen in vitro depends on CD4+ T cells or cytokines that signal through components of the IL-2R

Autor: M M, Elloso, H C, van der Heyde, A, Troutt, D D, Manning, W P, Weidanz

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 157(5)

We examined the cellular and molecular basis of the proliferative response of human gamma delta T cells in cultures of PBMC stimulated with blood-stage Plasmodium falciparum malarial Ag. Flow cytometry revealed that maximal gamma delta T cell prolife

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99e94685a543279ae6f9f90e81e1f619
https://pubmed.ncbi.nlm.nih.gov/8757332

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Participation of lymphocyte subpopulations in the pathogenesis of experimental murine cerebral malaria

Autor: D M, Yañez, D D, Manning, A J, Cooley, W P, Weidanz, H C, van der Heyde

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 157(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c8aa071557218b322525dd29594beaff
https://pubmed.ncbi.nlm.nih.gov/8759747

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