No evidence for enhanced disease with human polyclonal SARS-CoV-2 antibody in the ferret model.

Autor: Douglas S Reed, Anita K McElroy, Dominique J Barbeau, Cynthia M McMillen, Natasha L Tilston-Lunel, Shamkumar Nambulli, Emily Cottle, Theron C Gilliland, Hasala Rannulu, Jeneveve Lundy, Emily L Olsen, Katherine J O'Malley, Mengying Xia, Amy L Hartman, Thomas C Luke, Kristi Egland, Christoph Bausch, Hua Wu, Eddie J Sullivan, William B Klimstra, W Paul Duprex

Publikováno v: PLoS ONE, Vol 19, Iss 6, p e0290909 (2024)

Since SARS-CoV-2 emerged in late 2019, it spread from China to the rest of the world. An initial concern was the potential for vaccine- or antibody-dependent enhancement (ADE) of disease as had been reported with other coronaviruses. To evaluate this

Externí odkaz: https://doaj.org/article/e111baf91dfb4fc09c7205841d90cc09

Inoculation of raccoons with a wild-type-based recombinant canine distemper virus results in viremia, lymphopenia, fever, and widespread histological lesions

Autor: Dagmar Roelofs, Katharina S. Schmitz, Geert van Amerongen, Laurine C. Rijsbergen, Brigitta M. Laksono, Anouskha D. Comvalius, Sham Nambulli, Linda J. Rennick, Peter van Run, W. Paul Duprex, Judith M. A. van den Brand, Rik L. de Swart, Rory D. de Vries

Publikováno v: mSphere, Vol 8, Iss 4 (2023)

ABSTRACT Raccoons are naturally susceptible to canine distemper virus (CDV) infection and can be a potential source of spill-over events. CDV is a highly contagious morbillivirus that infects multiple species of carnivores and omnivores, resulting in

Externí odkaz: https://doaj.org/article/876ae783c798400abe51b32523aeac3c

Virology under the Microscope—a Call for Rational Discourse

Autor: Felicia Goodrum, Anice C. Lowen, Seema Lakdawala, James Alwine, Arturo Casadevall, Michael J. Imperiale, Walter Atwood, Daphne Avgousti, Joel Baines, Bruce Banfield, Lawrence Banks, Sumita Bhaduri-McIntosh, Deepta Bhattacharya, Daniel Blanco-Melo, David Bloom, Adrianus Boon, Steeve Boulant, Curtis Brandt, Andrew Broadbent, Christopher Brooke, Craig Cameron, Samuel Campos, Patrizia Caposio, Gary Chan, Anna Cliffe, John Coffin, Kathleen Collins, Blossom Damania, Matthew Daugherty, Kari Debbink, James DeCaprio, Terence Dermody, Jimmy Dikeakos, Daniel DiMaio, Rhoel Dinglasan, W. Paul Duprex, Rebecca Dutch, Nels Elde, Michael Emerman, Lynn Enquist, Bentley Fane, Ana Fernandez-Sesma, Michelle Flenniken, Lori Frappier, Matthew Frieman, Klaus Frueh, Michaela Gack, Marta Gaglia, Tom Gallagher, Denise Galloway, Adolfo García-Sastre, Adam Geballe, Britt Glaunsinger, Stephen Goff, Alexander Greninger, Meaghan Hancock, Eva Harris, Nicholas Heaton, Mark Heise, Ekaterina Heldwein, Brenda Hogue, Stacy Horner, Edward Hutchinson, Joseph Hyser, William Jackson, Robert Kalejta, Jeremy Kamil, Stephanie Karst, Frank Kirchhoff, David Knipe, Timothy Kowalik, Michael Lagunoff, Laimonis Laimins, Ryan Langlois, Adam Lauring, Benhur Lee, David Leib, Shan-Lu Liu, Richard Longnecker, Carolina Lopez, Micah Luftig, Jennifer Lund, Balaji Manicassamy, Grant McFadden, Michael McIntosh, Andrew Mehle, W. Allen Miller, Ian Mohr, Cary Moody, Nathaniel Moorman, Anne Moscona, Bryan Mounce, Joshua Munger, Karl Münger, Eain Murphy, Mojgan Naghavi, Jay Nelson, Christopher Neufeldt, Janko Nikolich, Christine O'Connor, Akira Ono, Walter Orenstein, David Ornelles, Jing-hsiung Ou, John Parker, Colin Parrish, Andrew Pekosz, Philip Pellett, Julie Pfeiffer, Richard Plemper, Stephen Polyak, John Purdy, Dohun Pyeon, Miguel Quinones-Mateu, Rolf Renne, Charles Rice, John Schoggins, Richard Roller, Charles Russell, Rozanne Sandri-Goldin, Martin Sapp, Luis Schang, Scott Schmid, Stacey Schultz-Cherry, Bert Semler, Thomas Shenk, Guido Silvestri, Viviana Simon, Gregory Smith, Jason Smith, Katherine Spindler, Megan Stanifer, Kanta Subbarao, Wesley Sundquist, Mehul Suthar, Troy Sutton, Andrew Tai, Vera Tarakanova, Benjamin tenOever, Scott Tibbetts, Stephen Tompkins, Zsolt Toth, Koenraad van Doorslaer, Marco Vignuzzi, Nicholas Wallace, Derek Walsh, Michael Weekes, Jason Weinberg, Matthew Weitzman, Sandra Weller, Sean Whelan, Elizabeth White, Bryan Williams, Christiane Wobus, Scott Wong, Andrew Yurochko

Publikováno v: mSphere, Vol 8, Iss 2 (2023)

ABSTRACT Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease burden with vaccines an

Externí odkaz: https://doaj.org/article/88d633fd96714f98a0ed8b9526e9581b

Sustained Replication of Synthetic Canine Distemper Virus Defective Genomes In Vitro and In Vivo

Autor: Natasha L. Tilston-Lunel, Stephen R. Welch, Sham Nambulli, Rory D. de Vries, Gregory W. Ho, David E. Wentworth, Reed Shabman, Stuart T. Nichol, Christina F. Spiropoulou, Rik L. de Swart, Linda J. Rennick, W. Paul Duprex

Publikováno v: mSphere, Vol 6, Iss 5 (2021)

Defective interfering (DI) genomes have long been considered inconvenient artifacts that suppressed viral replication in vitro

Externí odkaz: https://doaj.org/article/cfc5a68afbac41d1a19d0590c6581ed0

Measles skin rash: Infection of lymphoid and myeloid cells in the dermis precedes viral dissemination to the epidermis.

Autor: Brigitta M Laksono, Paola Fortugno, Bernadien M Nijmeijer, Rory D de Vries, Sonia Cordisco, Thijs Kuiken, Teunis B H Geijtenbeek, W Paul Duprex, Francesco Brancati, Rik L de Swart

Publikováno v: PLoS Pathogens, Vol 16, Iss 10, p e1008253 (2020)

Measles is characterized by fever and a maculopapular skin rash, which is accompanied by immune clearance of measles virus (MV)-infected cells. Histopathological analyses of skin biopsies from humans and non-human primates (NHPs) with measles rash ha

Externí odkaz: https://doaj.org/article/771134ce42394c0cabc8a183b2e3e40e