Zobrazeno 1 - 10
of 58
pro vyhledávání: '"W P, Arend"'
Autor:
W. P. Arend
Publikováno v:
Modern Rheumatology. 13:0001-0006
Interleukin-1 (IL-1) and tumor necrosis factor α (TNF-α) play key proinflammatory roles in a variety of human diseases, including rheumatoid arthritis (RA). IL-1 receptor antagonist (IL-1Ra) is a naturally occurring structural variant of IL-1 that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460c68828c50c39a12954e2c1dbfd3fd
https://doi.org/10.3109/s101650300000
https://doi.org/10.3109/s101650300000
Publikováno v:
The Journal of Immunology. 159:5905-5913
IL-1R antagonist (IL-1Ra) is a competitive inhibitor of the binding of IL-1 to IL-1R. IL-1Ra refers to two different proteins derived from the same gene by alternate splicing of two different first exons. One protein contains a leader sequence and is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33e3e8e98765fa4108262ac80ecbd55a
https://doi.org/10.4049/jimmunol.159.12.5905
https://doi.org/10.4049/jimmunol.159.12.5905
Publikováno v:
The Journal of Immunology. 153:4766-4774
These studies have examined the binding of the three IL-1 ligands, IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist (IL-1 ra), to soluble forms of types I and II IL-1Rs (sIL-1RI and sIL-1RII). This interaction was measured in direct binding experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6e6e7c52d04685bf062e8a49730000c
https://doi.org/10.4049/jimmunol.153.10.4766
https://doi.org/10.4049/jimmunol.153.10.4766
Publikováno v:
The Journal of Immunology. 153:3584-3593
Expression of the IL-1 receptor antagonist (IL-1ra) can be induced by treatment of monocytes and macrophages with LPS. We have previously demonstrated that the most proximal 294 bp of the human IL-1ra promoter are sufficient for full basal activity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b3778db2ba8bef77ca863b406e16bf6
https://doi.org/10.4049/jimmunol.153.8.3584
https://doi.org/10.4049/jimmunol.153.8.3584
Publikováno v:
The Journal of Immunology. 149:2000-2007
To study the molecular mechanisms involved in transcriptional regulation of the human IL-1R antagonist (IL-1ra) we have isolated 1680-bp of 5'-flanking region DNA from the IL-1ra gene. This region of DNA was sequenced and cloned into the luciferase e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e416c6914b370b284783590e9fa4a67
https://doi.org/10.4049/jimmunol.149.6.2000
https://doi.org/10.4049/jimmunol.149.6.2000
Autor:
John J. Voorhees, J S Haskill, A E Berger, W P Arend, Kevin D. Cooper, Lawrence S. Chan, Gary J. Fisher, Craig Hammerberg
Publikováno v:
Journal of Clinical Investigation. 90:571-583
The objective of these studies was to characterize the IL-1 inhibitory activity present in normal and psoriatic epidermis from clinically stable lesions. Fractionation of normal epidermal cytosol on a molecular sizing column failed to reveal the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d069d36f430ef9c3ab49b2ec658761
https://doi.org/10.1172/jci115896
https://doi.org/10.1172/jci115896
Publikováno v:
The Journal of Immunology. 148:3042-3048
The expression of cell surface nuclear Ag was studied by examining the binding of anti-histone mAb to viable human peripheral blood cells. Freshly isolated cells showed no binding of these mAb. However, in vitro culture in the presence of LPS induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e145df1edc8a7e1399f1b56a86449f29
https://doi.org/10.4049/jimmunol.148.10.3042
https://doi.org/10.4049/jimmunol.148.10.3042
Autor:
M, Mannik, W P, Arend
Publikováno v:
The Journal of Experimental Medicine
Preformed soluble immune complexes injected into rabbits or rhesus monkeys showed similar characteristics of disappearance from circulation. Complexes made with intact gammaG-antibodies and exceeding the Ag(2)Ab(2) lattice formation were rapidly remo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b0b4096862dd87f1dd959ba35db25156
https://pubmed.ncbi.nlm.nih.gov/19867366
https://pubmed.ncbi.nlm.nih.gov/19867366
Publikováno v:
The Journal of Immunology. 147:4218-4223
The objective of these experiments was to evaluate the production of IL-1ra, a specific receptor antagonist of IL-1, by human in vitro-derived macrophages, a model for differentiated macrophages. IL-1ra protein levels in supernatants and lysates of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf03c93b5222290e10060a8864e552a4
https://doi.org/10.4049/jimmunol.147.12.4218
https://doi.org/10.4049/jimmunol.147.12.4218
Publikováno v:
The Journal of Immunology. 147:1530-1536
Human monocytes may synthesize simultaneously both the agonist IL-1 beta and a specific receptor antagonist of IL-1 (IL-1ra). These studies examined whether monocyte production of these two structurally related cytokines was regulated differently. IL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9069b19ebbad96e1bdae25a8008875b4
https://doi.org/10.4049/jimmunol.147.5.1530
https://doi.org/10.4049/jimmunol.147.5.1530