Zobrazeno 1 - 10
of 18
pro vyhledávání: '"W O, Wilkison"'
Autor:
L. Kler, D. J. Dorey, W. O. Wilkison, S. Walker, Robert L. Dobbins, Robin L. O'Connor-Semmes, A. P. Sykes, J. D. Lorimer
Publikováno v:
Diabetes, Obesity and Metabolism. 17:94-97
We compared the efficacy of twice-daily doses of remogliflozin etabonate (RE) and once-daily pioglitazone with placebo for reduction in glycated haemoglobin (HbA1c) concentration. In this 12-week, double-blind, randomized, active- and placebo-control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51226f4d7f15c5ffab9fe84e2cbd26c6
https://doi.org/10.1111/dom.12391
https://doi.org/10.1111/dom.12391
Autor:
Robin L. O'Connor-Semmes, S. Walker, S. R. Almond, A. P. Sykes, Robert L. Dobbins, G. L. Kemp, L. Kler, W. O. Wilkison
Publikováno v:
Diabetes, obesitymetabolism. 17(1)
The sodium-dependent glucose transporter 2 (SGLT2) inhibitor remogliflozin etabonate (RE) was evaluated in a 12-week, double-blind, randomized, placebo- and active-controlled, parallel-group study. A total of 252 newly diagnosed and drug-naive people
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b598215280b05122682dabdcc8d9b1
https://pubmed.ncbi.nlm.nih.gov/25238025
https://pubmed.ncbi.nlm.nih.gov/25238025
Autor:
Y.-D. C. Halvorsen, W. O. Wilkison, Allen C. Clermont, Bruce M. Spiegelman, M Brittis, T. J. Mcgovern, S E Bursell
Publikováno v:
Journal of Clinical Investigation. 92:2872-2876
1-Butyryl-glycerol (monobutyrin) is a simple lipid product of adipocytes with angiogenic activity. Recent studies have shown that the biosynthesis of this compound is tightly linked to lipolysis, a process associated with changes in blood flow. We no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4fca4eff4ff136b09767f52d4e082d
https://doi.org/10.1172/jci116908
https://doi.org/10.1172/jci116908
Publikováno v:
Journal of Biological Chemistry. 266:16886-16891
1-Butyrylglycerol (monobutyrin) is a novel angiogenic compound that is synthesized and secreted during the differentiation of 3T3-F442A preadipocytes into adipocytes. To study the regulation of monobutyrin biosynthesis we have developed an assay util
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8525dc49a9ae557bda5973343520a7d1
https://doi.org/10.1016/s0021-9258(18)55385-0
https://doi.org/10.1016/s0021-9258(18)55385-0
Publikováno v:
Journal of Biological Chemistry. 265:477-482
The mouse adipsin gene encodes a serine protease with complement factor D activity that is expressed during adipocyte differentiation and is deficient in several animal models of obesity. We have investigated the regulation of adipsin expression by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dc9745752b8317e7b0de8fce5837033
https://doi.org/10.1016/s0021-9258(19)40255-x
https://doi.org/10.1016/s0021-9258(19)40255-x
Autor:
W O, Wilkison
Publikováno v:
IDrugs : the investigational drugs journal. 2(8)
HP-228 is a cytokine regulating agent from Trega Biosciences (formerly Houghten Pharmaceuticals). It is in phase II trials for the management of post-surgical pain and inflammation [195065]. The drug was indicated for the treatment of diabetes, obesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fec2839be8d1f18e96bd407aed32c447
https://pubmed.ncbi.nlm.nih.gov/16127656
https://pubmed.ncbi.nlm.nih.gov/16127656
Autor:
D A, Winegar, P J, Brown, W O, Wilkison, M C, Lewis, R J, Ott, W Q, Tong, H R, Brown, J M, Lehmann, S A, Kliewer, K D, Plunket, J M, Way, N L, Bodkin, B C, Hansen
Publikováno v:
Journal of lipid research. 42(10)
Fenofibrate is a member of the fibrate class of hypolipidemic agents used clinically to treat hypertriglyceridemia and mixed hyperlipidemia. The fibrates were developed primarily on the basis of their cholesterol and triglyceride lowering in rodents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba58c1244000b1754dcaf6c73c7bb1cd
https://pubmed.ncbi.nlm.nih.gov/11590209
https://pubmed.ncbi.nlm.nih.gov/11590209
Autor:
A, Sen, Y R, Lea-Currie, D, Sujkowska, D M, Franklin, W O, Wilkison, Y D, Halvorsen, J M, Gimble
Publikováno v:
Journal of cellular biochemistry. 81(2)
The current study was done to assess if heterogeneity existed in the degree of adipogenesis in stromal cells (preadipocytes) from multiple donors. In addition to conventional lipid-based methods, we have employed a novel signal amplification technolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c94ac6ce297e3bb2fc0889e6001a072e
https://pubmed.ncbi.nlm.nih.gov/11241671
https://pubmed.ncbi.nlm.nih.gov/11241671
Publikováno v:
The Journal of biological chemistry. 269(46)
Transcription of the adipocyte-specific adipsin gene is dramatically reduced in the adipose tissue of a number of genetically and chemically-induced obese rodents. To map the region of the adipsin gene that confers this response to obesity, transgeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4ef00e3e844ecdcc9db2d32e3006bfe
https://pubmed.ncbi.nlm.nih.gov/7961801
https://pubmed.ncbi.nlm.nih.gov/7961801
Autor:
W O, Wilkison, B M, Spiegelman
Publikováno v:
The Journal of biological chemistry. 268(4)
Monobutyrin (1-butyrylglycerol) is a simple lipid secreted by adipocytes that stimulates both angiogenesis and vasodilation of microvascular beds. While monobutyrin production is increased during lipolysis, little is known about the biosynthetic path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a5ae583cddaaa324b881fe561d07e64
https://pubmed.ncbi.nlm.nih.gov/8428959
https://pubmed.ncbi.nlm.nih.gov/8428959