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Specific activation of CD4–CD8– double-negative T cells by Trypanosoma cruzi-derived glycolipids induces a proinflammatory profile associated with cardiomyopathy in Chagas patients

Autor: Luísa Mourão Dias Magalhães, Lívia Silva Araújo Passos, Kenneth J. Gollob, M do C P Nunes, R P Soares, W. O. Dutra, Alexandre F. Marques

Publikováno v: Clinical and Experimental Immunology. 190:122-132

Summary Cardiomyopathy is the most severe outcome of Chagas disease, causing more than 12 000 deaths/year. Immune cells participate in cardiomyopathy development either by direct tissue destruction, or by driving inflammation. We have shown that CD4�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38cf0f8e2ddfcd5c789b5b3c24f2955f
https://doi.org/10.1111/cei.12992

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Distinct roles of Th17 and Th1 cells in inflammatory responses associated with the presentation of paucibacillary leprosy and leprosy reactions

Autor: João Santana da Silva, C. S. Varjão, A. R. de Jesus, D. T. de Oliveira, Steven G. Reed, C. B. Correia, Daniela R. Faria, Márcia Santos, R. P. de Almeida, P. L. dos Santos, Malcolm S. Duthie, M. do V. Simon, R. A. Cazzaniga, Márcio Bezerra Santos, W. O. Dutra

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

It is well established that helper T cell responses influence resistance or susceptibility to Mycobacterium leprae infection, but the role of more recently described helper T cell subsets in determining severity is less clear. To investigate the invo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950ae4d450da7de8953e104e25715880

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High Interleukin 17 Expression Is Correlated With Better Cardiac Function in Human Chagas Disease

Autor: W. O. Dutra, Luísa Mourão Dias Magalhães, Maria do Carmo Pereira Nunes, Fernanda Nobre Amaral Villani, Kenneth J. Gollob, Manoel Otávio da Costa Rocha

Publikováno v: The Journal of Infectious Diseases. 207:661-665

This study was designed to investigate whether the expression of interleukin 17 (IL-17) is associated with the indeterminate or cardiac clinical forms of Chagas disease and whether IL-17 expression can be correlated with patients' cardiac function. O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c916e919fa9477700a552aee5fc415bf
https://doi.org/10.1093/infdis/jis724

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CD4+ T cells defined by their Vβ T cell receptor expression are associated with immunoregulatory profiles and lesion size in human leishmaniasis

Autor: Tatjana Souza Lima Keesen, Kenneth J. Gollob, Daniela R. Faria, Olívia Bacellar, Lis Ribeiro do Vale Antonelli, W. O. Dutra, Luiz Henrique Guimarães, Edgar M. Carvalho

Publikováno v: Clinical and Experimental Immunology. 165:338-351

Summary Leishmaniasis is caused by infection with the protozoan parasite, Leishmania, that parasitizes human cells, and the cellular immune response is essential for controlling infection. In order to measure the host T cell response to Leishmania in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22acbaf0a7d3378087528c7b7c9c2ec
https://doi.org/10.1111/j.1365-2249.2011.04430.x

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TNFA and IL10 Gene Polymorphisms are not Associated with Periodontitis in Brazilians

Autor: José Eustáquio Costa, Kenneth J. Gollob, W. O. Dutra, Paredes Moreira, Ricardo Santiago Gomez

Publikováno v: The Open Dentistry Journal

IL-10 and TNF-α are cytokines that have complex and opposing roles in the inflammatory responses. G/A polymorphisms at position –1082 ofIL10and –308 ofTNFAgenes have been reported to influence the expression of IL-10 and TNF-α, respectively. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296c93692b68763eb34c8784577212d6
http://europepmc.org/articles/PMC2745565

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Expression of neuronal calcium sensor-1 (NCS-1) is decreased in leukocytes of schizophrenia and bipolar disorder patients

Autor: Fernando Silva Neves, Kenneth J. Gollob, Humberto Correa, W. O. Dutra, Rodrigo Nicolato, Marco Aurélio Romano-Silva, Débora Marques de Miranda, Bruno R. Souza, Karen C.L. Torres, Alexandre Guimarães de Almeida Barros, A.M. Sampaio

Publikováno v: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 33:229-234

Schizophrenia (SCZ) and bipolar disorder (BPD) are severe illnesses representing an enormous social, familiar and individual burden that affect 1% of the population world-wide. Several evidences indicate abnormalities of the dopamine system in both S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855a9765587e1c6a7ddc0b7a1909ead1
https://doi.org/10.1016/j.pnpbp.2008.11.011

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The IL1A (?889) gene polymorphism is associated with chronic periodontal disease in a sample of Brazilian individuals

Autor: Ricardo Santiago Gomez, José Eustáquio Costa, Kenneth J. Gollob, W. O. Dutra, Paula Rocha Moreira

Publikováno v: Journal of Periodontal Research. 42:23-30

Background and Objective: It has been proposed that genotypes reflective of polymorphisms in cytokine genes can predispose individuals to disease by enhancing inflammatory processes. The C/T polymorphism at position −889 of the IL1A gene influences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa6ee8ec90a9bcf8c035187b727a9f78
https://doi.org/10.1111/j.1600-0765.2006.00910.x

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Mucosal Leishmaniasis Patients Display an Activated Inflammatory T-cell Phenotype Associated with a Nonbalanced Monocyte Population

Autor: Soraya Gaze, A. R. De Jesus, Hélio A. Lessa, Marcus Miranda Lessa, Luiz Henrique Guimarães, Paulo Roberto Lima Machado, Lucas P. Carvalho, Edgar M. Carvalho, Kenneth J. Gollob, W. O. Dutra

Publikováno v: Scandinavian Journal of Immunology. 63:70-78

Leishmania braziliensis is a parasite that can induce at least two clinical forms of leishmaniasis in humans: cutaneous leishmaniasis (CL) and mucosal leishmaniasis (ML). In humans, the specific mechanisms that determine which form will develop follo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1a6d68b4bd05c59a318521681f491e
https://doi.org/10.1111/j.1365-3083.2005.01707.x

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Effect of LACK and KMP11 on IFN-gamma Production by Peripheral Blood Mononuclear Cells from Cutaneous and Mucosal Leishmaniasis Patients

Autor: A. Ribeiro de Jesus, Lucas P. Carvalho, Edgar M. Carvalho, Sara Passos, Muñoz Soto, W. O. Dutra, C. Alonso, Kenneth J. Gollob

Publikováno v: Scandinavian Journal of Immunology. 61:337-342

The immune modulatory properties of recombinant antigens Kinetoplasmid membrane protein-11 (KMP11) and Leishmania homologue of receptors for activated C kinase (LACK) in cutaneous leishmaniasis (CL) and mucosal leishmaniasis (ML) patients were evalua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7d42e50c21a5f4cfef3f57ffbdc71f
https://doi.org/10.1111/j.1365-3083.2005.01581.x

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Flow Cytometric Determination of Cellular Sources and Frequencies of Key Cytokine-Producing Lymphocytes Directed against Recombinant LACK and Soluble Leishmania Antigen in Human Cutaneous Leishmaniasis

Autor: Wilson Mayrink, W. O. Dutra, Richard M. Locksley, Kenneth J. Gollob, Aldina Barral, B. Gontijo, Roque P. Almeida, Edgar M. Carvalho, F. A. Martins, R. L. A. Bottrel, Manoel Barral-Netto

Publikováno v: Infection and Immunity. 69:3232-3239

Leishmaniasis, caused by infection with the protozoan parasiteLeishmania, affects millions of individuals worldwide, causing serious morbidity and mortality. This study directly determined the frequency of cells producing key immunoregulatory cytokin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68163ae562d1beb7e8119a525c2385e2
https://doi.org/10.1128/iai.69.5.3232-3239.2001

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