Zobrazeno 1 - 10 of 94 pro vyhledávání: '"W Nicol Keith"'
1
Akademický článek
A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds.
Autor: Claire J Cairney, Lauren S Godwin, Alan E Bilsland, Sharon Burns, Katrina H Stevenson, Lynn McGarry, John Revie, Jon D Moore, Ceri M Wiggins, Rebecca S Collinson, Clare Mudd, Elpida Tsonou, Mahito Sadaie, Dorothy C Bennett, Masashi Narita, Christopher J Torrance, W Nicol Keith
Publikováno v: PLoS Genetics, Vol 13, Iss 8, p e1006942 (2017)
Senescence is a universal barrier to immortalisation and tumorigenesis. As such, interest in the use of senescence-induction in a therapeutic context has been gaining momentum in the past few years; however, senescence and immortalisation remain unde
Externí odkaz: https://doaj.org/article/9c37fdc4728e4b2584673b3d2d9b5b8b
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2
Akademický článek
Extensive telomere erosion is consistent with localised clonal expansions in Barrett's metaplasia.
Autor: Boitelo T Letsolo, Rhiannon E Jones, Jan Rowson, Julia W Grimstead, W Nicol Keith, Gareth J S Jenkins, Duncan M Baird
Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0174833 (2017)
Barrett's oesophagus is a premalignant metaplastic condition that predisposes patients to the development of oesophageal adenocarcinoma. However, only a minor fraction of Barrett's oesophagus patients progress to adenocarcinoma and it is thus essenti
Externí odkaz: https://doaj.org/article/d8f9b80fd6ea4b6196df8cda58935a64
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3
Akademický článek
Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms.
Autor: Alan E Bilsland, Katrina Stevenson, Yu Liu, Stacey Hoare, Claire J Cairney, Jon Roffey, W Nicol Keith
Publikováno v: PLoS Computational Biology, Vol 10, Iss 2, p e1003448 (2014)
Cancer cells depend on transcription of telomerase reverse transcriptase (TERT). Many transcription factors affect TERT, though regulation occurs in context of a broader network. Network effects on telomerase regulation have not been investigated, th
Externí odkaz: https://doaj.org/article/12af634056c54dc780e056ce775e8e7b
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4
Akademický článek
Dynamic telomerase gene suppression via network effects of GSK3 inhibition.
Autor: Alan E Bilsland, Stacey Hoare, Katrina Stevenson, Jane Plumb, Natividad Gomez-Roman, Claire Cairney, Sharon Burns, Kyle Lafferty-Whyte, Jon Roffey, Tim Hammonds, W Nicol Keith
Publikováno v: PLoS ONE, Vol 4, Iss 7, p e6459 (2009)
Telomerase controls telomere homeostasis and cell immortality and is a promising anti-cancer target, but few small molecule telomerase inhibitors have been developed. Reactivated transcription of the catalytic subunit hTERT in cancer cells controls t
Externí odkaz: https://doaj.org/article/1b41ea64dd364875a5dfb77a3f62bf69
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5
Akademický článek
A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation
Autor: Alan E. Bilsland, Yu Liu, Andrew Turnbull, David Sumpton, Katrina Stevenson, Claire J. Cairney, Susan M. Boyd, Jon Roffey, David Jenkinson, W. Nicol Keith
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 9, Pp 893-907 (2019)
Telomere signaling and metabolic dysfunction are hallmarks of cell aging. New agents targeting these processes might provide therapeutic opportunities, including chemoprevention strategies against cancer predisposition. We report identification and c
Externí odkaz: https://doaj.org/article/936206170ac349faab43d8b1ddaedfcd
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6
Data from Markers of Adenocarcinoma Characteristic of the Site of Origin: Development of a Diagnostic Algorithm
Autor: Karin A. Oien, W. Nicol Keith, Christopher Bellamy, Caroline Verbeke, Jacqueline Mooney, Ian Downie, Alexandra K. Bell, Jan Komorowski, Ernst C. Wit, Torgeir R. Hvidsten, Jayne L. Dennis
Purpose: Patients with metastatic adenocarcinoma of unknown origin are a common clinical problem. Knowledge of the primary site is important for their management, but histologically, such tumors appear similar. Better diagnostic markers are needed to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c64dd357e19c88804d6b69181e4539
https://doi.org/10.1158/1078-0432.c.6518334
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10
Immortalization of T-Cells Is Accompanied by Gradual Changes in CpG Methylation Resulting in a Profile Resembling a Subset of T-Cell Leukemias
Autor: Göran Roos, Krystyna H. Chrzanowska, Erik Forestier, Mattias Landfors, Sofie Degerman, W. Nicol Keith, Patrik Rydén, John Revie, Jan Konrad Siwicki, Emma Andersson Evelönn, Magnus Borssén
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 7, Pp 606-615 (2014)
Neoplasia (New York, N.Y.)
We have previously described gene expression changes during spontaneous immortalization of T-cells, thereby identifying cellular processes important for cell growth crisis escape and unlimited proliferation. Here, we analyze the same model to investi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a36dc964cb2574fef86f0ee10ca9e72
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