Zobrazeno 1 - 10
of 215
pro vyhledávání: '"W Nicholas Haining"'
Autor:
Lan Chen, Beatriz Millare, Jeremy Chen, Aaron Cooper, Natalie Bezman, Angela Boroughs, Suchismita Mohanty, David DeTomaso, Amy-Jo Casbon, Thomas J Gardner, Anzhi Yao, Ashley Cass, Alma Gomez, Manching Ku, Lionel Berthoin, Meng Lim, Azalea Ong, Vince Thomas, Nicholas Quant, Brian Hsu, Levi Gray-Rupp, W Nicholas Haining
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/5e4a90e7ee90474c9a89859560f13aa5
Autor:
Yashaswi Shrestha, Michael Quigley, Travis Hughes, Robert T Manguso, Natalie B Collins, Rose Al Abosy, Brian C Miller, Kevin Bi, Qihong Zhao, Jeffrey J Ishizuka, Kathleen B Yates, Hans W Pope, Marc Wadsworth, Alex K Shalek, Jesse S Boehm, William C Hahn, John G Doench, W Nicholas Haining
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Oncogenes act in a cell-intrinsic way to promote tumorigenesis. Whether oncogenes also have a cell-extrinsic effect on suppressing the immune response to cancer is less well understood.Methods We use an in vivo expression screen of known c
Externí odkaz:
https://doaj.org/article/2f18639e65804873a00ab93aef07c6bc
Autor:
Genevieve E. Martin, Debattama R. Sen, Matthew Pace, Nicola Robinson, Jodi Meyerowitz, Emily Adland, John P. Thornhill, Mathew Jones, Ane Ogbe, Lucia Parolini, Natalia Olejniczak, Panagiota Zacharopoulou, Helen Brown, Christian B. Willberg, Nneka Nwokolo, Julie Fox, Sarah Fidler, W. Nicholas Haining, John Frater
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
T cell dysfunction occurs early following HIV infection, impacting the emergence of non-AIDS morbidities and limiting curative efforts. ART initiated during primary HIV infection (PHI) can reverse this dysfunction, but the extent of recovery is unkno
Externí odkaz:
https://doaj.org/article/3d165a2ffd8b4a029910eb0c288ef7ef
Autor:
Martin W. LaFleur, Thao H. Nguyen, Matthew A. Coxe, Kathleen B. Yates, Justin D. Trombley, Sarah A. Weiss, Flavian D. Brown, Jacob E. Gillis, Daniel J. Coxe, John G. Doench, W. Nicholas Haining, Arlene H. Sharpe
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The use of functional genomics in primary immune cells has been limited by inefficient vector delivery and risk of perturbing cell states. Here the authors present CHimeric IMmune Editing (CHIME) for in vivo evaluation of gene function and pooled scr
Externí odkaz:
https://doaj.org/article/f4cc26f0a06e487587662b0cfb8d4512
Autor:
Kristen E. Pauken, Jernej Godec, Pamela M. Odorizzi, Keturah E. Brown, Kathleen B. Yates, Shin Foong Ngiow, Kelly P. Burke, Seth Maleri, Shannon M. Grande, Loise M. Francisco, Mohammed-Alkhatim Ali, Sabrina Imam, Gordon J. Freeman, W. Nicholas Haining, E. John Wherry, Arlene H. Sharpe
Publikováno v:
Cell Reports, Vol 31, Iss 13, Pp 107827- (2020)
Summary: The PD-1 pathway regulates dysfunctional T cells in chronic infection and cancer, but the role of this pathway during acute infection remains less clear. Here, we demonstrate that PD-1 signals are needed for optimal memory. Mice deficient in
Externí odkaz:
https://doaj.org/article/8fdbfcfc91f44b0bbe20702e1a1824ab
Supplementary Data from CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation
Autor:
Kwok-Kin Wong, Nathanael S. Gray, David A. Barbie, Geoffrey I. Shapiro, Haribabu Arthanari, Norman E. Sharpless, W. Nicholas Haining, Jerome Ritz, Gordon J. Freeman, Sangeetha Palakurthi, Raphael Bueno, Genevieve M. Boland, Viswanath Gunda, Sareh Parangi, Jochen H. Lorch, William G. Richards, Jay C. Strum, Patrick J. Roberts, Eric Haines, Amanda J. Rode, Megan E. Cavanaugh, Ting Chen, Peng Gao, Hua Zhang, Yanxi Zhang, Annan Yang, Lauren E. Bufe, Max M. Quinn, Ashley A. Merlino, Patrick H. Lizotte, John E. Bisi, Jessica A. Sorrentino, Grit S. Herter-Sprie, Chensheng W. Zhou, Michaela Bowden, Cloud P. Paweletz, Elena Ivanova, Amir R. Aref, Hongye Liu, Wei Huang, Sandeep Chhabra, Kathleen Yates, Ruben Dries, Shuai Li, Russell W. Jenkins, Eric S. Wang, Jiehui Deng
Figure S1. Characterization of cells and CDK4/6 inhibitors; Figure S2. CDK6 phosphorylates serine residues of the regulatory domain of NFAT4 (NFATc3); Figure S3. Analysis of lung tumor immune infiltrates after CDK4/6 inhibition from KrasG12D (Kras),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a01c7e72b06ed917fff29065c873f6
https://doi.org/10.1158/2159-8290.22531849.v1
https://doi.org/10.1158/2159-8290.22531849.v1
Autor:
Lee M. Nadler, Robert L. Coffman, George Demetri, Patrick Wen, Jeffrey Morgan, Jeffrey Kutok, Xiaochun Li, Donna Neuberg, Paul Sims, Suzanne George, Kate Russell, Steven Rivoli, Jill Angelosanto, John Evans, Thomas Brenn, Linda Drury, Holger Kanzler, Jeffrey Davies, W. Nicholas Haining
Supplementary Data from CpG Oligodeoxynucleotides Alter Lymphocyte and Dendritic Cell Trafficking in Humans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9a9e677a7e9db4aaa9e8a531e30862
https://doi.org/10.1158/1078-0432.22439638.v1
https://doi.org/10.1158/1078-0432.22439638.v1
Autor:
Lee M. Nadler, Robert L. Coffman, George Demetri, Patrick Wen, Jeffrey Morgan, Jeffrey Kutok, Xiaochun Li, Donna Neuberg, Paul Sims, Suzanne George, Kate Russell, Steven Rivoli, Jill Angelosanto, John Evans, Thomas Brenn, Linda Drury, Holger Kanzler, Jeffrey Davies, W. Nicholas Haining
Purpose: CpG oligodeoxynucleotides (CpG-ODN) are being investigated as cancer vaccine adjuvants because they mature plasmacytoid dendritic cells (PDC) into potent antigen-presenting cells. CpG-ODN also induce PDC to secrete chemokines that alter lymp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d711fbde563e84f3fee23c9e76d03378
https://doi.org/10.1158/1078-0432.c.6517075.v1
https://doi.org/10.1158/1078-0432.c.6517075.v1
Autor:
Angelo A. Cardoso, Lee M. Nadler, Stephen E. Sallan, Rob Pieters, Monique L. den Boer, Paolo Ghia, Nilufer P. Seth, Scott A. Armstrong, Zhinan Xia, Sascha Ansén, W. Nicholas Haining, Sara Maia
Supplementary Tables 1-3 from Gene Expression Profiling Identifies BAX-δ as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8452e573875443b6077216385665ec9
https://doi.org/10.1158/0008-5472.22367648
https://doi.org/10.1158/0008-5472.22367648
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