Zobrazeno 1 - 10
of 39
pro vyhledávání: '"W N Keith"'
Publikováno v:
British Journal of Cancer
Telomere length is maintained by two known mechanisms, activation of telomerase or alternative lengthening of telomeres (ALT). The ALT pathway is more commonly activated in tumours of mesenchymal origin, although the mechanisms involved in the decisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1639e76131ddbb21eb20d7edce5f35
https://doi.org/10.1038/sj.bjc.6604328
https://doi.org/10.1038/sj.bjc.6604328
Autor:
Jantine L. Westra, Karin A. Oien, R. M. W. Hofstra, W N Keith, Harry Hollema, Michael Schaapveld, J.Th.M. Plukker, R. Mauritz, G.J. Peters, Inge Platteel, Charles H.C.M. Buys
Publikováno v:
Westra, J L, Hollema, H, Schaapveld, M, Platteel, I, Oien, K A, Keith, W N, Mauritz, R, Peters, G J, Buys, C H, Hofstra, R M & Plukker, JT 2005, ' Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients ', Annals of Oncology, vol. 16, no. 10, pp. 1646-1653 . https://doi.org/10.1093/annonc/mdi316
Annals of Oncology, 16(10), 1646-1653. Oxford University Press
Annals of Oncology, 16(10), 1646-1653. Oxford University Press
Background: The predictive value of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) expression on long-term survival by influencing 5-fluorouracil (5-FU) effect were determined in primary tumours and node metastases of stage III c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836e97f8c173040fd965a2cd2bece6dd
https://doi.org/10.1093/annonc/mdi316
https://doi.org/10.1093/annonc/mdi316
Publikováno v:
Oncogene. 25:61-69
Basal telomerase activity is dependent on expression of the hTERT and hTR genes and upregulation of telomerase gene expression is associated with tumour development. It is therefore possible that signal transduction pathways involved in tumour develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3f130b57e0a6949140962cbe919574
https://doi.org/10.1038/sj.onc.1209011
https://doi.org/10.1038/sj.onc.1209011
Autor:
Daniel Sliva, William G. Helferich, Mark E. Prince, H. Ungefroren, Gunjan Guha, Sophie Chen, Sarah K. Thompson, Hiromasa Fujii, S. Salman Ashraf, Xujuan Yang, Dipita Bhakta, Masaru Katoh, Massimo Zollo, Chandra S. Boosani, Asfar S. Azmi, Amr Amin, Frank Gieseler, W N Keith, Daniele Santini, Andrew James Sanders, Somaira Nowsheen, Malancha Sarkar, P. Dhawan, Alexandros G. Georgakilas, Daniela Spano, Dorota Halicka, Lin Ye, Francesco Pantano, Pochi R. Subbarayan, Elena Niccolai, Wen Guo Jiang, Alan Bilsland, Katia Aquilano, Amedeo Amedei, Kanya Honoki, Maria Rosa Ciriolo
Publikováno v:
Seminars in cancer biology.
Cancer is a key health issue across the world, causing substantial patient morbidity and mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to distant sites, with metastatic diseases accounting for a vast perc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3011e6f88444ac0998da8fb1fc0e5b
https://pubmed.ncbi.nlm.nih.gov/25865774
https://pubmed.ncbi.nlm.nih.gov/25865774
Publikováno v:
Journal of Oral Pathology & Medicine. 30:577-581
Background: Telomerase is detectable in 85% of cancers, but is largely repressed in normal tissues. Human telomerase RNA (hTR) inhibition is a promising anti-cancer strategy, but requires differential expression between malignant and normal tissue. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::924f22e70b095e8cb3ddf47b60bb0321
https://doi.org/10.1034/j.1600-0714.2001.301001.x
https://doi.org/10.1034/j.1600-0714.2001.301001.x
Autor:
van der Ate Zee, W N Keith, de Steven Jong, Gert Jan Meersma, Harmen Hollema, MN Helder, Gba Wisman, de Elisabeth G. E. Vries
Publikováno v:
Human Pathology. 31:1304-1312
This study was performed to determine upregulation of the human telomerase RNA component (hTR) and mRNA of the catalytic subunit of telomerase (hTERT) in (pre)malignant cervical lesions, to analyze possible intralesional heterogeneity of hTR expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6597d4055a98397c01e4b2515461df
https://doi.org/10.1053/hupa.2000.19299
https://doi.org/10.1053/hupa.2000.19299
Autor:
Margaret C. Frame, D W Owens, W N Keith, Valerie G. Brunton, M Agochiya, Eric Kenneth Parkinson, C Paraskeva
Publikováno v:
ResearcherID
Focal adhesion kinase (pp125FAK) is present at sites of cell/extracellular matrix adhesion and has been implicated in the control of cell behaviour. In particular, as a key component of integrin-stimulated signal transduction pathways, pp125FAK is in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5aa5be657b3b56ffd8946513660b87
https://doi.org/10.1038/sj.onc.1202957
https://doi.org/10.1038/sj.onc.1202957
Autor:
D. M. Black, S F Hoare, Eric Kenneth Parkinson, R McFarlane, Jiangqin Zhao, S Muir, W N Keith
Publikováno v:
Oncogene. 16:1345-1350
Variation in telomerase activity is correlated with cellular senescence and tumour progression. However, although the enzymatic activity of telomerase has been well studied, very little is known about how expression of telomerase genes is regulated i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270699a21c85d595943c4dbc13d71f3f
https://doi.org/10.1038/sj.onc.1201892
https://doi.org/10.1038/sj.onc.1201892
Publikováno v:
ResearcherID
Maintenance of telomere structure by the ribonucleoprotein enzyme telomerase is considered central to the development of most human cancers. However, regulatory mechanisms governing telomerase expression during oncogenesis are largely unknown. We add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8439a099e7fe5731a04358ee7cb857
https://doi.org/10.1038/sj.onc.1201620
https://doi.org/10.1038/sj.onc.1201620
Autor:
Paul R. Gause, W N Keith, James Warneke, Marianne B. Powell, Allan Balmain, Maria Lluria-Prevatt, S Linardopolous
Publikováno v:
ResearcherID
The TP-ras transgenic mouse line expresses an activated human T24 Ha-ras gene with a mutation in codon 12, regulated by a mouse tyrosinase promoter. The transgene is expressed in melanocytes of the skin, eyes, and brain. The mice develop cutaneous me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0bb7481014902619526ff95a6e5886b
https://doi.org/10.1002/(sici)1098-2744(199709)20:1<78::aid-mc9>3.0.co
https://doi.org/10.1002/(sici)1098-2744(199709)20:1<78::aid-mc9>3.0.co