Výsledky vyhledávání

Investigation of photodynamic effect caused by MPPa-PDT on breast cancer

Autor: W N Leung, H Q Yuan, X Y Hu, X Tian, Lianying Zhang, F A Cui, Y Y Tian

Publikováno v: Laser Physics Letters. 9:754-758

Breast cancer is the common malignant tumor, the incidence increases with age. Photodynamic therapy (PDT) is a new technique applied in tumors, which involves the administration of a tumor localizing photosensitizer and it is followed by the activati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ee99e9053e2acee7cd1cf706409eb86
https://doi.org/10.7452/lapl.201210077

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Mitochondria-involved apoptosis induced by MPPa mediated photodynamic therapy

Autor: Y Y Tian, X Tian, F A Cui, H Q Yuan, D D Xu, W N Leung

Publikováno v: Laser Physics Letters. 5:746-751

Numerous new photosensitizers are now in various stages of trials demonstrating the broad applicability of Photodynamic therapy (PDT). However, only a handful of photosensitizers have received regulatory approval. Lack of effective photosensitizers h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8838dedbe3bb5dad9b39b0ba6e85f09
https://doi.org/10.1002/lapl.200810052

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Photodynamic Effects of mTHPC on Human Colon Adenocarcinoma Cells: Photocytotoxicity, Subcellular Localization and Apoptosis¶

Autor: W. N. Leung, X. Sun, N. K. Mak, C. M. N. Yow

Publikováno v: Photochemistry and Photobiology. 75:406-411

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6472a5eaf4a028400c58e9d799edd87e
https://doi.org/10.1562/0031-8655(2002)0750406peomoh2.0.co2

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The Binding Characteristics and Intracellular Localization of Temoporfin (mTHPC) in Myeloid Leukemia Cells: Phototoxicity and Mitochondrial Damage¶

Autor: J. Y. Chen, N. K. Mak, C. M. N. Yow, M. C. Fung, L. C. Chiu, W. N. Leung, N. H. Cheung

Publikováno v: Photochemistry and Photobiology. 72:541-547

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d327ab1a60bf47404604c0412ed5a6a6
https://doi.org/10.1562/0031-8655(2000)0720541tbcail2.0.co2

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Photodynamic Therapy with Pyropheophorbide-a Methyl Ester in Human Lung Carcinoma Cancer Cell: Efficacy, Localization and Apoptosis¶

Autor: X. Sun, W. N. Leung

Publikováno v: Photochemistry and Photobiology. 75:644-651

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::878694cab886181f5cddfa55413c7409
https://doi.org/10.1562/0031-8655(2002)0750644ptwpam2.0.co2

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Photodynamic therapy with pyropheophorbide-a methyl ester in human lung carcinoma cancer cell: efficacy, localization and apoptosis

Autor: X, Sun, W N, Leung

Publikováno v: Photochemistry and photobiology. 75(6)

Pyropheophorbide-a methyl ester (MPPa) is a semisynthetic photosensitizer derived from chlorophyll a. The absorption peak of MPPa in organic solvent and in cells was at 667 and 674 nm, respectively. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazoliu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4c00f832ee205187e7d92b1f70d0affa
https://pubmed.ncbi.nlm.nih.gov/12081327

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Photodynamic effects of mTHPC on human colon adenocarcinoma cells: photocytotoxicity, subcellular localization and apoptosis

Autor: W N, Leung, X, Sun, N K, Mak, C M, Yow

Publikováno v: Photochemistry and photobiology. 75(4)

The photodynamic properties of meta-tetra(hydroxyphenyl)chlorin (mTHPC), a promising second-generation photosensitizer, were investigated using a human colon adenocarcinoma cell line (Colo 201 cells). The study on photocytotoxicity using 3-(4,5-dimet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::beb2cd13d17ecff1ac114a40285aba17
https://pubmed.ncbi.nlm.nih.gov/12003131

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The binding characteristics and intracellular localization of temoporfin (mTHPC) in myeloid leukemia cells: phototoxicity and mitochondrial damage

Autor: J Y, Chen, N K, Mak, C M, Yow, M C, Fung, L C, Chiu, W N, Leung, N H, Cheung

Publikováno v: Photochemistry and photobiology. 72(4)

The state of aggregation of the photosensitizer meso-tetrahydroxyphenylchlorin (mTHPC) in both cell free and intracellular environment was elucidated by comparing its absorption and excitation spectra. In methanol, mTHPC existed as monomers and stron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::47155c8747fd0c65fbb1fd1924980575
https://pubmed.ncbi.nlm.nih.gov/11045727

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A comparison of the photodynamic effects of temoporfin (mTHPC) and MC540 on leukemia cells: efficacy and apoptosis

Autor: J Y, Chen, N K, Mak, J M, Wen, W N, Leung, S C, Chen, M C, Fung, N H, Cheung

Publikováno v: Photochemistry and photobiology. 68(4)

The photodynamic effects of temoporfin (meso-tetrahydroxyphenylchlorin, mTHPC) and merocyanine 540 (MC540) in murine myeloid leukemia M1 and WEHI 3B (JCS) cells were compared. The mTHPC was found to be more potent and selective. At a lethal dosage of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::956d0b03eda687f91128b58e8ee3f158
https://pubmed.ncbi.nlm.nih.gov/9796437

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