Zobrazeno 1 - 10 of 38 pro vyhledávání: '"W N, Konings"'
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Autor: Hans V. Westerhoff, Jacky L. Snoep, J.-H.S. Hofmeyr, Johann M. Rohwer, W. N. Konings
Publikováno v: Molecular Biology Reports. 29:107-112
A numerical model of the LmrA multi-drug transport system of Lactococcus lactis is used to explore the possibility of distinguishing experimentally between two putative transport mechanisms, i.e., the vacuum-cleaner and the flippase mechanisms. This
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3696f0ce14fb09aac5c7ef875603c98
https://doi.org/10.1023/a:1020344922249
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2
How to distinguish between the vacuum cleaner and flippase mechanisms of the lmrA multi-drug transporter in Lactococcus lactis
Autor: J H S, Hofmeyr, J M, Rohwer, J L, Snoep, H V, Westerhoff, W N, Konings
Publikováno v: Molecular biology reports. 29(1-2)
A numerical model of the LmrA multi-drug transport system of Lactococcus lactis is used to explore the possibility of distinguishing experimentally between two putative transport mechanisms, i.e., the vacuum-cleaner and the flippase mechanisms. This
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9264ec5af11e65aa1740cd829c68a742
https://pubmed.ncbi.nlm.nih.gov/12241038
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3
Structure and dynamics of the membrane-embedded domain of LmrAinvestigated by coupling polarized ATR-FTIR spectroscopy and (1)H/(2)H exchange
Autor: V, Grimard, C, Vigano, A, Margolles, R, Wattiez, H W, van Veen, W N, Konings, J M, Ruysschaert, E, Goormaghtigh
Publikováno v: Biochemistry. 40(39)
Bacterial LmrA, an integral membrane protein of Lactococcus lactis, confers multidrug resistance by mediating active extrusion of a wide variety of structurally unrelated compounds. Similar to its eucaryotic homologue P-gp, this protein is a member o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e30bf7adc30bb427a5aa45f76a70327b
https://pubmed.ncbi.nlm.nih.gov/11570888
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4
Secondary and tertiary structure changes of reconstituted LmrA induced by nucleotide binding or hydrolysis. A fourier transform attenuated total reflection infrared spectroscopy and tryptophan fluorescence quenching analysis
Autor: C, Vigano, A, Margolles, H W, van Veen, W N, Konings, J M, Ruysschaert
Publikováno v: The Journal of biological chemistry. 275(15)
LmrA, a membrane protein of Lactococcus lactis, extrudes amphiphilic compounds from the inner leaflet of the cytoplasmic membrane, using energy derived from ATP hydrolysis. A combination of total reflection Fourier transform infrared spectroscopy, (2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::22184e55a5e52d8593b8e7f872741acf
https://pubmed.ncbi.nlm.nih.gov/10753896
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6
Stator structure and subunit composition of the V(1)/V(0) Na(+)-ATPase of the thermophilic bacterium Caloramator fervidus
Autor: T, Ubbink-Kok, E J, Boekema, J F, van Breemen, A, Brisson, W N, Konings, J S, Lolkema
Publikováno v: Journal of molecular biology. 296(1)
The V-type Na(+)-ATPase of the thermophilic, anaerobic bacterium Caloramator fervidus was purified to homogeneity. The subunit compositions of the catalytic V(1) and membrane-embedded V(0) parts were determined and the structure of the enzyme complex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::36baa5661b71166b38ffe83444ab35ab
https://pubmed.ncbi.nlm.nih.gov/10656834
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8
Multidrug resistance in lactic acid bacteria: molecular mechanisms and clinical relevance
Autor: H W, van Veen, A, Margolles, M, Putman, K, Sakamoto, W N, Konings
Publikováno v: Antonie van Leeuwenhoek. 76(1-4)
The active extrusion of cytotoxic compounds from the cell by multidrug transporters is one of the major causes of failure of chemotherapeutic treatment of tumor cells and of infections by pathogenic microorganisms. The secondary multidrug transporter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::215fe8c739dbfd8660a6a11776e8b850
https://pubmed.ncbi.nlm.nih.gov/10532389
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9
Compartmentalization and transport in beta-lactam antibiotic biosynthesis by filamentous fungi
Autor: M, van de Kamp, A J, Driessen, W N, Konings
Publikováno v: Antonie van Leeuwenhoek. 75(1-2)
A proper description of the biosynthesis of fungal beta-lactam antibiotics requires detailed knowledge of the cell biology of the producing organisms. This involves a delineation of the compartmentalization of the biosynthetic pathways, and of the co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d22ac8d9aa818f2466c68b75d2e6cd7
https://pubmed.ncbi.nlm.nih.gov/10422581
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10
Drug efflux proteins in multidrug resistant bacteria
Autor: H W, van Veen, W N, Konings
Publikováno v: Biological chemistry. 378(8)
Bacteria contain an array of transport proteins in their cytoplasmic membrane. Many of these proteins play an important role in conferring resistance to toxic compounds. The multidrug efflux systems encountered in prokaryotic cells are very similar t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e91be31d8c7c74cbd6e329d03f9521c5
https://pubmed.ncbi.nlm.nih.gov/9377471
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