Zobrazeno 1 - 2
of 2
pro vyhledávání: '"W N, Howald"'
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(3)
Oxidative conversion of all-trans-retinol (t-ROH) to all-trans-retinal (t-RAL) is recognized as the rate-limiting step for biosynthesis of all-trans-retinoic acid from t-ROH in mammalian hepatic tissues. The purpose of this study was to investigate t
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(5)
The purpose of this work was to evaluate the effect of mutual unbound inhibitor and unbound enzyme depletion on the potency of three antifungal cytochrome P-450 (CYP)3A inhibitors with over 1000-fold range in enzyme affinity. Incubations were perform