Výsledky vyhledávání - "W N, Hittelman"

A randomized clinical trial of 4-hydroxyphenylretinamide for high-grade squamous intraepithelial lesions of the cervix

Autor: M, Follen, E N, Atkinson, D, Schottenfeld, A, Malpica, L, West, S, Lippman, C, Zou, W N, Hittelman, R, Lotan, W K, Hong

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(11)

Previous trials of topical trans-retinoic acid treatment of cervical intraepithelial neoplasia (CIN) grades 2 and 3 led to a statistically significant regression of CIN 2, but not CIN 3. We tested N-(4-hydroxyphenyl)retinamide (4-HPR), a promising or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::20cd399e59935166c7f7a4d90c012f87
https://pubmed.ncbi.nlm.nih.gov/11705848

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Cyclin D1 and p16 alterations in advanced premalignant lesions of the upper aerodigestive tract: role in response to chemoprevention and cancer development

Autor: V A, Papadimitrakopoulou, J, Izzo, L, Mao, J, Keck, D, Hamilton, D M, Shin, A, El-Naggar, P, den Hollander, D, Liu, W N, Hittelman, W K, Hong

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(10)

To better understand the role of G(1)-S transition regulator abnormalities in the pathogenesis of advanced premalignant lesions of the upper aerodigestive tract and the biological effects of chemoprevention, we studied biopsies obtained sequentially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77b720c5db940e9b7b4dc972eb44b3d3
https://pubmed.ncbi.nlm.nih.gov/11595705

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p53 protein accumulation and genomic instability in head and neck multistep tumorigenesis

Autor: D M, Shin, N, Charuruks, S M, Lippman, J J, Lee, J Y, Ro, W K, Hong, W N, Hittelman

Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 10(6)

Head and neck cancer develops in a multistep process and is associated with increasing frequencies of p53 alterations and with increasing genomic instability. To study the relationship of p53 alterations and genomic instability during head and neck t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a005e8de15c22cc2e8f5e9c606e229bb
https://pubmed.ncbi.nlm.nih.gov/11401909

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Chromosome polysomy and histological characteristics in oral premalignant lesions

Autor: J, Kim, D M, Shin, A, El-Naggar, J S, Lee, C, Corrales, S M, Lippman, W K, Hong, W N, Hittelman

Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 10(4)

Head and neck tumorigenesis has been postulated to represent a multistep process driven by the accumulation of carcinogen-induced genetic changes throughout the exposed tissue field. To better explore this genetic instability process at the tissue le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::097ea5e68743bae96423618e86cbe8fa
https://pubmed.ncbi.nlm.nih.gov/11319171

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Modulation of proliferating cell nuclear antigen in the bronchial epithelium of smokers

Autor: F R, Khuri, J S, Lee, S M, Lippman, J J, Lee, S, Kalapurakal, R, Yu, J Y, Ro, R C, Morice, W K, Hong, W N, Hittelman

Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 10(4)

Clinical chemoprevention trials seek to intervene in the carcinogenic process to suppress, reverse, or delay the development of invasive cancer. Dysregulated cell growth is a hallmark of epithelial carcinogenesis, and proliferating cell nuclear antig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9446152f19f9ad401191acdb41410eed
https://pubmed.ncbi.nlm.nih.gov/11319170

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Quantitative nuclear morphometry by image analysis for prediction of recurrence of ductal carcinoma in situ of the breast

Autor: A, Hoque, S M, Lippman, I V, Boiko, E N, Atkinson, N, Sneige, A, Sahin, D M, Weber, S, Risin, M D, Lagios, R, Schwarting, W J, Colburn, K, Dhingra, M, Follen, G J, Kelloff, C W, Boone, W N, Hittelman

Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 10(3)

Clinical management of ductal carcinoma in situ (DCIS) remains a challenge because significant proportions of patients experience recurrence after conservative surgical treatment. Unfortunately, it is difficult to prospectively identify, using object

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::27d378aad52439e86e4537e5bc23b7ce
https://pubmed.ncbi.nlm.nih.gov/11303595

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Expression of vascular endothelial growth factor and microvessel density in head and neck tumorigenesis

Autor: K, Tae, A K, El-Naggar, E, Yoo, L, Feng, J J, Lee, W K, Hong, W N, Hittelman, D M, Shin

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(7)

Angiogenesis is a fundamental process in tumor growth and metastasis, and its significance and that of vascular endothelial growth factor (VEGF) expression as prognostic indicators have been documented for various types of human tumors. However, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::24cff90e098f9dc80fbecf1811836fd9
https://pubmed.ncbi.nlm.nih.gov/10914730

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Predicting cancer development in oral leukoplakia: ten years of translational research

Autor: J J, Lee, W K, Hong, W N, Hittelman, L, Mao, R, Lotan, D M, Shin, S E, Benner, X C, Xu, J S, Lee, V M, Papadimitrakopoulou, C, Geyer, C, Perez, J W, Martin, A K, El-Naggar, S M, Lippman

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(5)

Our 10-year translational study of the oral premalignant lesion (OPL) model has advanced the basic understanding of carcinogenesis. Although retinoids have established activity in this model, a substantial percentage of our OPL patients progress to c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e93b62df8c7baf5400c13f361410867
https://pubmed.ncbi.nlm.nih.gov/10815888

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P53 expression and polysomies of chromosome 9, 17 in head and neck cancer prognosis

Autor: N, Charuruks, D M, Shin, N, Voravud, J Y, Ro, W K, Hong, W N, Hittelman

Publikováno v: Journal of the Medical Association of Thailand = Chotmaihet thangphaet. 82(5)

Sixty-nine cases of head and neck squamous cell carcinoma were examined by immunohistochemistry for p53 and chromosome in situ hybridization for chromosome 9 and 17 to determine the relationship between p53 expression and polysomies of chromosome 9 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::40c5b51dedd7dc0571b1ccfecae6a86d
https://pubmed.ncbi.nlm.nih.gov/10443096

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