Zobrazeno 1 - 10
of 165
pro vyhledávání: '"W Matthew Petroll"'
Autor:
Matthew Gillings, MD, Andrew Mastro, MD, Xunzhi Zhang, Kelly Kiser, MD, Jane Gu, Chao Xing, PhD, Danielle M. Robertson, OD, PhD, W. Matthew Petroll, PhD, V. Vinod Mootha, MD
Publikováno v:
Ophthalmology Science, Vol 3, Iss 1, Pp 100214- (2023)
Objective: Seventy percent of Fuchs’ endothelial corneal dystrophy (FECD) cases are caused by an intronic trinucleotide repeat expansion in the transcription factor 4 gene (TCF4). The objective of this study was to characterize the corneal subbasal
Externí odkaz:
https://doaj.org/article/39d71abdce6640558ab4c049e6052c14
Effects of Topography and PDGF on the Response of Corneal Keratocytes to Fibronectin-Coated Surfaces
Autor:
Kevin H. Lam, Tarik Z. Shihabeddin, Jacob A. Awkal, Alex M. Najjar, Miguel Miron-Mendoza, Daniel P. Maruri, Victor D. Varner, W. Matthew Petroll, David W. Schmidtke
Publikováno v:
Journal of Functional Biomaterials, Vol 14, Iss 4, p 217 (2023)
During corneal wound healing, corneal keratocytes are exposed to both biophysical and soluble cues that cause them to transform from a quiescent state to a repair phenotype. How keratocytes integrate these multiple cues simultaneously is not well und
Externí odkaz:
https://doaj.org/article/e883c5af1a8e435d83ab39f304bac3cc
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Following injury and refractive surgery, corneal wound healing can initiate a protracted fibrotic response that interferes with ocular function. This fibrosis is related, in part, to the myofibroblast differentiation of corneal keratocytes in respons
Externí odkaz:
https://doaj.org/article/b54775678df54c3da907717c08ab648a
Publikováno v:
American Journal of Ophthalmology. 251:77-89
Autor:
Tina B. McKay, Pouriska B. Kivanany, Sarah E. Nicholas, Okhil K. Nag, Michael H. Elliott, W. Matthew Petroll, Dimitrios Karamichos
Publikováno v:
Metabolites, Vol 12, Iss 7, p 626 (2022)
We have previously reported the flavonoid, quercetin, as a metabolic regulator and inhibitor of myofibroblast differentiation in vitro. Our current study evaluated the effects of topical application of quercetin on corneal scar development using two
Externí odkaz:
https://doaj.org/article/81857624c50643118d973e5deb18d97a
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract This study utilizes high resolution multi-dimensional imaging to identify temporal and spatial changes in cell/extracellular matrix (ECM) patterning mediating cell migration, fibrosis, remodeling and regeneration during wound healing. Photor
Externí odkaz:
https://doaj.org/article/40d118bf16d9433881159e7adc92e021
Autor:
Miguel Miron-Mendoza, Dalia Vazquez, Nerea García-Rámila, Hikaru R. Ikebe, W. Matthew Petroll
Publikováno v:
Bioengineering, Vol 7, Iss 3, p 89 (2020)
We previously reported that corneal fibroblasts within 3D fibrin matrices secrete, bind, and organize fibronectin into tracks that facilitate cell spreading and migration. Other cells use these fibronectin tracks as conduits, which leads to the devel
Externí odkaz:
https://doaj.org/article/22bbfd5d9eff41bfb8b9a30c35b351ea
Publikováno v:
J Cataract Refract Surg
Corneal crosslinking is a U.S. Food and Drug Administration--approved therapy to stiffen the cornea and prevent progression of corneal ectasia in patients with keratoconus. The standard procedure involves removal of the corneal epithelium (epithelial
Autor:
W. Matthew Petroll, Neema Lakshman
Publikováno v:
Journal of Functional Biomaterials, Vol 6, Iss 2, Pp 222-240 (2015)
The goal of this study was to investigate how alterations in extracellular matrix (ECM) biophysical properties modulate corneal keratocyte phenotypes in response to specific wound healing cytokines and Rho GTPases. Rabbit corneal keratocytes were pla
Externí odkaz:
https://doaj.org/article/e855ff2cc18f42ed92e4a50337e6c881
Autor:
Krithika S. Iyer, Daniel P. Maruri, Kara E. Peak, David W. Schmidtke, W. Matthew Petroll, Victor D. Varner
Publikováno v:
Exp Eye Res
During corneal wound healing, keratocytes present within the corneal stroma become activated into a repair phenotype upon the release of growth factors, such as transforming growth factor-beta 1 (TGF-β1) and platelet-derived growth factor-BB (PDGF-B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5843c4ec27467cd0e15eb357ca9d3d
https://europepmc.org/articles/PMC10163834/
https://europepmc.org/articles/PMC10163834/