Zobrazeno 1 - 10
of 15
pro vyhledávání: '"W M Mackin"'
Autor:
W M Mackin, Gary J. Fisher, Joseph J. Baldassare, B Sahagan, Alan P. Tarver, Patricia A. Henderson
Publikováno v:
Biochemical Journal. 291:235-240
Activation of human platelets by the arachidonic acid metabolite thromboxane A2 and the thromboxane A2 mimic U46619 is mediated through phosphoinositide-specific phospholipase C-catalysed hydrolysis of phosphoinositides. We have established condition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d91a10dc78bb8e1a6ff835378a6994
https://doi.org/10.1042/bj2910235
https://doi.org/10.1042/bj2910235
Autor:
W M, Mackin
Publikováno v:
IDrugs : the investigational drugs journal. 1(6)
XOMA is developing Neuprex, an injectable recombinant protein fragment (rBPI-21) of the naturally-occurring bactericidal/permeability increasing (BPI) protein, for serious infections and infectious complications of trauma and surgery. Neuprex is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e62738f0e19484e92c144155d3e6a8ef
https://pubmed.ncbi.nlm.nih.gov/18465627
https://pubmed.ncbi.nlm.nih.gov/18465627
Publikováno v:
The Journal of Immunology. 144:2671-2677
Intraperitoneal injection of zymosan into mice induces a peritonitis characterized by cellular influx, plasma leakage and the appearance of arachidonic acid (AA) metabolites. We report that zymosan injection also stimulates the accumulation of AA, do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a06f1c877e67f72bbadb0c07f2444437
https://doi.org/10.4049/jimmunol.144.7.2671
https://doi.org/10.4049/jimmunol.144.7.2671
Autor:
W M, Mackin
Publikováno v:
IDrugs : the investigational drugs journal. 1(8)
BASF is developing the monoclonal antibody MAK-195F, a tumor necrosis factor (TNF)-alpha antagonist, for the potential treatment of septic shock. It is in phase III clinical trials in the US and Europe [198973]. Results from the trials were expected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::601253b6898dcaf99512a27b0f08a6be
https://pubmed.ncbi.nlm.nih.gov/16196485
https://pubmed.ncbi.nlm.nih.gov/16196485
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 144(7)
Intraperitoneal injection of zymosan into mice induces a peritonitis characterized by cellular influx, plasma leakage and the appearance of arachidonic acid (AA) metabolites. We report that zymosan injection also stimulates the accumulation of AA, do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13fd1304f29f9a35ee7925bc404529df
https://pubmed.ncbi.nlm.nih.gov/2108209
https://pubmed.ncbi.nlm.nih.gov/2108209
Publikováno v:
Advances in experimental medicine and biology. 275
Two "in vivo" models of inflammation have been used to investigate the role of phospholipases A2 (PLA2) in inflammation. These models are casein-induced peritonitis in the rat and zymosan-induced peritonitis in the mouse. The extracellular PLA2 activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da12bb4509d474068c00c0259ac708e2
https://pubmed.ncbi.nlm.nih.gov/2122642
https://pubmed.ncbi.nlm.nih.gov/2122642
Publikováno v:
Skin pharmacology : the official journal of the Skin Pharmacology Society. 3(1)
The possible utility of DuP 654, a potent 5-lipoxygenase inhibitor, for treating human inflammatory skin disease was investigated in murine skin treated with 1.0 mg arachidonic acid (AA). When DuP 654 was applied to murine skin treated with AA, it in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::146460f0c5b6f114fc77d6181db2a98f
https://pubmed.ncbi.nlm.nih.gov/2167696
https://pubmed.ncbi.nlm.nih.gov/2167696
Publikováno v:
Proceedings of the National Academy of Sciences. 81:767-770
Using the exogenous substrate [1-14C]oleate-labeled autoclaved Escherichia coli, we have demonstrated that the chemotactic factors fMet-Leu-Phe, complement component C5a, and leukotriene B4 [(5S,12R)-dihydroxy-6-cis,8-trans,11-trans,14-cis-icosatetra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b655eb40529f85b0f05b7a06cbf41313
https://doi.org/10.1073/pnas.81.3.767
https://doi.org/10.1073/pnas.81.3.767
Publikováno v:
The Journal of Immunology. 129:1608-1611
F Met-Leu-[3H]Phe and f Nle-Leu-[3H]Phe binding to rabbit peritoneal neutrophils and purified membranes were measured at 4 degrees C silicone oil centrifugation assays, and the results were analyzed by the LIGAND computer program, which permits analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6028f94a7639aaecf93f1b016b8155a3
https://doi.org/10.4049/jimmunol.129.4.1608
https://doi.org/10.4049/jimmunol.129.4.1608
Publikováno v:
Journal of Cellular Physiology. 115:243-248
Arachidonic acid when added simultaneously with the chemotactic peptide formyl-methionyl-leucyl-phenylalanine (f-Met-Leu-Phe) inhibits the ability of the latter to initiate several but not all of its effects on rabbit peritoneal neutrophils. Stimulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93aca84a2594cc0a55a6575fb7547f13
https://doi.org/10.1002/jcp.1041150305
https://doi.org/10.1002/jcp.1041150305