Zobrazeno 1 - 10
of 79
pro vyhledávání: '"W M, Niessen"'
Autor:
Annemijn Vis, Bente J. de Kort, Wojciech Szymczyk, Jan Willem van Rijswijk, Sylvia Dekker, Rob Driessen, Niels Wijkstra, Paul F. Gründeman, Hans W. M. Niessen, Henk M. Janssen, Serge H. M. Söntjens, Patricia Y. W. Dankers, Anthal I. P. M. Smits, Carlijn V. C. Bouten, Jolanda Kluin
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Pliable microfibrous, bioresorbable elastomeric heart valve prostheses are investigated in search of sustainable heart valve replacement. These cell-free implants recruit cells and trigger tissue formation on the valves in situ. Our aim is t
Externí odkaz:
https://doaj.org/article/cd42ea311b8e4f6dbdd34aa53ab1b497
Autor:
Chinnaswamy Tiruppathi, Dong-Mei Wang, Mohammad Owais Ansari, Shabana Bano, Yoshikazu Tsukasaki, Amitabha Mukhopadhyay, Jagdish C. Joshi, Christian Loch, Hans W. M. Niessen, Asrar B. Malik
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Vascular endothelial cadherin (VE-cadherin) expressed at endothelial adherens junctions (AJs) is vital for vascular integrity and endothelial homeostasis. Here we identify the requirement of the ubiquitin E3-ligase CHFR as a key mechanism of
Externí odkaz:
https://doaj.org/article/bd6da7d597ac42feba25fde2e33ebb02
Autor:
Eva R. Meulendijks, Rushd F. M. Al-Shama, Makiri Kawasaki, Benedetta Fabrizi, Jolien Neefs, Robin Wesselink, Auriane C. Ernault, Sander Piersma, Thang V. Pham, Connie R. Jimenez, Jaco C. Knol, Wim J. P. van Boven, Antoine H. G. Driessen, Tim A. C. de Vries, Britt van der Leeden, Hans W. M. Niessen, Onno J. de Boer, Sébastien P. J. Krul, Joris R. de Groot
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Background Epicardial adipose tissue (EAT) secretome induces fibrosis. Fibrosis, primarily extracellular matrix (ECM) produced by fibroblasts, creates a substrate for atrial fibrillation (AF). Whether the EAT secretome from patients with AF
Externí odkaz:
https://doaj.org/article/b6cf7114ad5148eaab99d938a3be13c0
Autor:
Zeineb Bakey, Oscar A Cabrera, Julia Hoefele, Dinu Antony, Kaman Wu, Michael W Stuck, Dimitra Micha, Thibaut Eguether, Abigail O Smith, Nicole N van der Wel, Matias Wagner, Lara Strittmatter, Philip L Beales, Julie A Jonassen, Isabelle Thiffault, Maxime Cadieux-Dion, Laura Boyes, Saba Sharif, Beyhan Tüysüz, Desiree Dunstheimer, Hans W M Niessen, William Devine, Cecilia W Lo, Hannah M Mitchison, Miriam Schmidts, Gregory J Pazour
Publikováno v:
PLoS Genetics, Vol 19, Iss 6, p e1010796 (2023)
Motile and non-motile cilia play critical roles in mammalian development and health. These organelles are composed of a 1000 or more unique proteins, but their assembly depends entirely on proteins synthesized in the cell body and transported into th
Externí odkaz:
https://doaj.org/article/e3c33751139d4a74a9903b2f1e069797
Autor:
Johann S. deBono, Jeffrey R. Harris, Saskia M. Burm, Adriaan Vanderstichele, Mischa A. Houtkamp, Saida Aarass, Ruth Riisnaes, Ines Figueiredo, Daniel Nava Rodrigues, Rossitza Christova, Siel Olbrecht, Hans W. M. Niessen, Sigrid R. Ruuls, Danita H. Schuurhuis, Jeroen J. Lammerts van Bueren, Esther C. W. Breij, Ignace Vergote
Publikováno v:
Cancer Reports, Vol 6, Iss 2, Pp n/a-n/a (2023)
Abstract Background Elevated tissue factor (TF) expression, although restricted in normal tissue, has been reported in multiple solid cancers, and expression has been associated with poor prognosis. This manuscript compares TF expression across vario
Externí odkaz:
https://doaj.org/article/0e98ad51ac3645c9bafd82abf01d3681
Publikováno v:
Forensic Sciences Research, Vol 0, Iss 0, Pp 1-9 (2021)
Interpreting a myocardial inflammation as causal, contributory or as of no significance at all in the cause of death can be challenging, especially in cases where other pathologic and/or medico-legal findings are also present. To further evaluate the
Externí odkaz:
https://doaj.org/article/2736ead0c55746c1925bf50348d10584
Autor:
S. N. van der Crabben, F. L. Komdeur, E. J. Nossent, R. H. Lekanne Deprez, E. A. Broekhuizen, C. van der Werf, A. M. C. Vermeer, H. W. M. Niessen, A. C. Houweling
Publikováno v:
Cardiogenetics, Vol 11, Iss 2, Pp 68-72 (2021)
Sudden death, especially at a young age, may be caused by an underlying genetic cause. Hereditary conditions with an increased risk of sudden death at a young age include cardiomyopathies, arrhythmia syndromes, and hereditary thoracic aortic aneurysm
Externí odkaz:
https://doaj.org/article/65b137ada75e494c89e69f1cd9d86902
Autor:
Suat Simsek, Casper G Schalkwijk, Hans W M Niessen, Amber Korn, Umit Baylan, Paul A J Krijnen
Publikováno v:
Open Heart, Vol 8, Iss 2 (2021)
Background Myocardial infarction (MI) is associated with mental health disorders, in which neuroinflammation and cerebral microvascular dysfunction may play a role. Previously, we have shown that the proinflammatory factors Nε-(carboxymethyl)lysine
Externí odkaz:
https://doaj.org/article/23625a756bc64b768f444e5b9c53d600
Autor:
Friso M. de Beer, Mark P. V. Begieneman, Joris J. T. H. Roelofs, Janneke Horn, Hans W. M. Niessen, Marcus J. Schultz, Wim K. Lagrand
Publikováno v:
Intensive Care Medicine Experimental, Vol 7, Iss S1, Pp 1-11 (2019)
Abstract Background The complement system has frequently been suggested to play a role in the pathophysiology of acute respiratory distress syndrome (ARDS). The current study explored the association between pulmonary depositions of a complement acti
Externí odkaz:
https://doaj.org/article/cdfc8d20f93343d5864a28de5670f9d1
Autor:
Yingwen Hu, Bingbing Wang, Jiayin Shen, Stewart A. Low, Karson S. Putt, Hans W. M. Niessen, Eric L. Matteson, Linda Murphy, Clemens Ruppert, Gerrit Jansen, Stephen J. Oliver, Yang Feng, Dimiter S. Dimitrov, Cheryl Nickerson-Nutter, Philip S. Low
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-14 (2019)
Abstract Objectives Most therapies for autoimmune and inflammatory diseases either neutralize or suppress production of inflammatory cytokines produced by activated macrophages (e.g., TNFα, IL-1, IL-6, IL-17, GM-CSF). However, no approved therapies
Externí odkaz:
https://doaj.org/article/1dc2d4681dd3423db7d7c71fbd322d51