Zobrazeno 1 - 10
of 75
pro vyhledávání: '"W M, Kuehl"'
Autor:
W. M. Kuehl, Yan W. Asmann, Anna V. Roschke, Peter Leif Bergsagel, Yulia N. Demchenko, Wei Dong Chen
Publikováno v:
Nucleic Acids Research
Using a combination of array comparative genomic hybridization, mate pair and cloned sequences, and FISH analyses, we have identified in multiple myeloma cell lines and tumors a novel and recurrent type of genomic rearrangement, i.e. interchromosomal
Autor:
B Van Ness, Pieter Sonneveld, Jin Jen, Amit Kumar Mitra, Ujjal Kumar Mukherjee, Shaji Kumar, W. M. Kuehl, Taylor Harding, Vincent Rajkumar, Jin Sung Jang, R HongZheng, Ying Li
Publikováno v:
Blood Cancer Journal, 7:e581. Nature Publishing Group
Blood Cancer Journal
Blood Cancer Journal
Extensive interindividual variation in response to chemotherapy is a major stumbling block in achieving desirable efficacy in the treatment of cancers, including multiple myeloma (MM). In this study, our goal was to develop a gene expression signatur
Autor:
Daniel L. Riggs, Jonathan J Keats, Victoria M. Garbitt, P L Bergsagel, S Van Wier, K Tamizhmani, Yulia N. Demchenko, Leslie A. Brents, A V Roschke, W. M. Kuehl, Maurizio Affer, W D Chen, Marta Chesi, R Fonseca
Publikováno v:
Leukemia
MYC locus rearrangements-often complex combinations of translocations, insertions, deletions and inversions-in multiple myeloma (MM) were thought to be a late progression event, which often did not involve immunoglobulin genes. Yet, germinal center a
Autor:
Herbert C. Morse, Siegfried Janz, Dong-Mi Shin, W. M. Kuehl, Christopher M. Bean, A. Zingone, C. M. Cultraro
Publikováno v:
Leukemia. 24:1171-1178
The t(4;14) translocation in multiple myeloma (MM) simultaneously dysregulates two apparent oncogenes: fibroblast growth factor receptor 3 (FGFR3) controlled by the 3′ immunoglobulin heavy chain enhancer on der(14) and MMSET controlled by the intro
Autor:
J L Daggett, Timothy P. Bender, P L Bergsagel, W. M. Kuehl, M S Kulkarni, Michael E. Williams
Publikováno v:
Leukemia. 16:127-134
Multiple myeloma (MM) is a clonal neoplasm of plasma cells which offers an excellent model to study multistep molecular oncogenesis. In 20-25% of primary tumors and cell lines examined, cyclin D1 is overexpressed due to the translocation t(11;14)(q13
Novel near-diploid ovarian cancer cell line derived from a highly aneuploid metastatic ovarian tumor
Autor:
Anna V. Roschke, Ester Rozenblum, Susana Korolevich, Hongling Liao, W. M. Kuehl, Jack Zhu, James Cherry, Thomas Ried, José R. Sotelo-Silveira, David J. Munroe, Christopher Lau, Gina Y. Kim, Nicole McNeil, Paul S. Meltzer
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 8, p e0182610 (2017)
PLoS ONE, Vol 12, Iss 8, p e0182610 (2017)
A new ovarian near-diploid cell line, OVDM1, was derived from a highly aneuploid serous ovarian metastatic adenocarcinoma. A metastatic tumor was obtained from a 47-year-old Ashkenazi Jewish patient three years after the first surgery removed the pri
Publikováno v:
Hematology. 2001:157-177
Multiple myeloma (MM) is a malignancy of the plasma cell characterized by migration and localization to the bone marrow where cells then disseminate and facilitate the formation of bone lesions. Unfortunately, while treatment of this disease is effec
Publikováno v:
Annals of Oncology. 11:S131-S135
Summary Background: Chromosome translocations involving the immunoglobulin heavy chain gene (IgH) on 14q32 are a seminal event in the pathogenesis of many B-cell malignancies. Since myeloma is a post-germinal center tumor of mature, isotype switched
Publikováno v:
Leukemia. 22:459-461
Translocation t(4;14) retains prognostic significance even in the setting of high-risk molecular signature
Publikováno v:
European Journal of Immunology. 23:2532-2539
The BLR1 gene, isolated initially from Burkitt's lymphoma cells (Eur. J. Immunol. 1992. 22: 2795), encodes a G protein-coupled receptor with significant relationship to receptors for chemokines (IL-8, MIP-1 alpha) and neuropeptides. The murine homolo