Zobrazeno 1 - 10
of 10
pro vyhledávání: '"W M, Campana"'
Publikováno v:
Journal of Dental Research. 101:1025-1033
Head and neck cancer (HNC) affects over 890,000 people annually worldwide and has a mortality rate of 50%. Aside from poor survival, HNC pain impairs eating, drinking, and talking in patients, severely reducing quality of life. Different pain phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952358d1beb9d211d1def45aae2cc604
https://doi.org/10.1177/00220345221088527
https://doi.org/10.1177/00220345221088527
Colocalization and Complex Formation Between Prosaposin and Monosialoganglioside GM3 in Neural Cells
Autor:
Maria Giammatteo, Masao Hiraiwa, Antonio Pavan, Maurizio Sorice, John S. O'Brien, T. Griggi, W M Campana, Giuseppe M. Pontieri, Tina Garofalo, Roberta Misasi
Publikováno v:
Scopus-Elsevier
Prosaposin, the precursor of saposins A, B, C, and D, was recently identified as a neurotrophic factor in vitro as well as in vivo. Its neurotrophic activity has been localized to a linear 12-amino acid sequence located in the NH2-terminal portion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4fa9759148c0e9e7f2e9adedacd0fde
https://doi.org/10.1046/j.1471-4159.1998.71062313.x
https://doi.org/10.1046/j.1471-4159.1998.71062313.x
Autor:
N L Eskeland, Nigel A. Calcutt, L. Mohiuddin, W M Campana, Kevin C. Dines, John S. O'Brien, Andrew P. Mizisin
Publikováno v:
Journal of Neuropathology and Experimental Neurology. 58:628-636
We have recently demonstrated that prosaposin is a neurotrophic and myelinotrophic factor with the active trophic sequence located at the N-terminal region of the saposin C domain. There are also reports that prosaposin mRNA is increased distal to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5490cdfbe4cc227feb3948598ae5aecc
https://doi.org/10.1097/00005072-199906000-00007
https://doi.org/10.1097/00005072-199906000-00007
Publikováno v:
Brain research. Molecular brain research. 71(2)
The aim of the study was to determine which factors regulated the expression of neurotrophin-3 (NT-3) mRNA in cultured primary Schwann cells derived from sciatic nerve of neonatal rats. Treatment of primary Schwann cells with the adenylate cyclase ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04551874471f07bb14b9eaa55294c9c
https://pubmed.ncbi.nlm.nih.gov/10521580
https://pubmed.ncbi.nlm.nih.gov/10521580
Publikováno v:
Glia. 26(4)
Recently, we demonstrated that prosaposin and prosaptides (peptides encompassing the neurotrophic sequence in prosaposin) prevent cell death and increase extracellular regulated kinase (ERK) phosphorylation and sulfatide content in primary Schwann ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d818c561893e062b652e92c981d7f0e
https://pubmed.ncbi.nlm.nih.gov/10383054
https://pubmed.ncbi.nlm.nih.gov/10383054
Publikováno v:
Biochimica et biophysica acta. 1427(3)
Western blotting and immunodetection with three antibodies were used to probe conditioned media of breast cancer cells (MDA231, MDA435, MCF-7) for prosaposin, a lysosomal protein that occurs in milk. It was readily detected in media from these cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed46ade6a2ecd2394e5637b3d5fd8680
https://pubmed.ncbi.nlm.nih.gov/10350655
https://pubmed.ncbi.nlm.nih.gov/10350655
Publikováno v:
Musclenerve. 22(2)
A transgenic mouse model has been established in which the cytokine interferon-gamma (IFN-gamma) is overexpressed through the action of the acetylcholine receptor epsilon promoter acting at the neuromuscular junction. While originally developed as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::002825f4b10c8a48f35af2bfbc5becdc
https://pubmed.ncbi.nlm.nih.gov/10024128
https://pubmed.ncbi.nlm.nih.gov/10024128
Publikováno v:
International Journal of Molecular Medicine.
Erythropoietin (Epo) is a hematopoietic factor that facilitates erythroid progenitor cell proliferation and differentiation. Recently, trophic effects of Epo have been observed in central cholinergic neurons. We have confirmed the neurotrophic factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0bab5f814e546cc69a6d15c0cf0316a
https://doi.org/10.3892/ijmm.1.1.235
https://doi.org/10.3892/ijmm.1.1.235
Publikováno v:
Biochemical and biophysical research communications. 240(2)
Prosaposin, the precursor of sphingolipid activator protein (saposins A-D), has been identified as a neurotrophic factor capable of inducing neural differentiation and preventing cell death. The putative prosaposin receptor was partially purified fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95108afb8f94253ac001d33217c72ab9
https://pubmed.ncbi.nlm.nih.gov/9388493
https://pubmed.ncbi.nlm.nih.gov/9388493
Prosaposin, the precursor of saposins A, B, C, and D, was recently identified as a neurotrophic factor. Herein prosaposin was found to increase sulfatide concentrations in primary and transformed Schwann cells (iSC) and oligodendrocytes (differentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54f53caefc8d2f32f562dda4ef18385
https://europepmc.org/articles/PMC20801/
https://europepmc.org/articles/PMC20801/
