Výsledky vyhledávání

Akademický článek

Direct structural analysis of a single acyl carrier protein domain in fatty acid synthase from the fungus Saccharomyces cerevisiae

Autor: Elnaz Khalili Samani, Amy C. Chen, Jennifer W. Lou, David L. Dai, Alexander F. A. Keszei, Guihong Tan, Charles Boone, Martin Grininger, Mohammad T. Mazhab-Jafari

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)

Abstract Acyl carrier protein (ACP) is the work horse of polyketide (PKS) and fatty acid synthases (FAS) and acts as a substrate shuttling domain in these mega enzymes. In fungi, FAS forms a 2.6 MDa symmetric assembly with six identical copies of FAS

Externí odkaz: https://doaj.org/article/426835cd27af4b18b2741bd4d0b37a91

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Atomic model for core modifying region of human fatty acid synthase in complex with Denifanstat

Autor: S. M. Naimul Hasan, Jennifer W. Lou, Alexander F. A. Keszei, David L. Dai, Mohammad T. Mazhab-Jafari

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)

Abstract Fatty acid synthase (FASN) catalyzes the de novo synthesis of palmitate, a 16-carbon chain fatty acid that is the primary precursor of lipid metabolism and an important intracellular signaling molecule. FASN is an attractive drug target in d

Externí odkaz: https://doaj.org/article/8feb1bdab32e4d7d8e92197eddf1190f

Zobrazit plný text záznamu

Akademický článek

Corrigendum to 'Genetic analyses of blood β-hydroxybutyrate predicted from milk infrared spectra and its association with longevity and female reproductive traits in Holstein cattle' (J. Dairy Sci. 105:3269–3281)

Autor: W. Lou, H. Zhang, H. Luo, Z. Chen, R. Shi, X. Guo, Y. Zou, L. Liu, L.F. Brito, G. Guo, Y. Wang

Publikováno v: Journal of Dairy Science, Vol 106, Iss 4, Pp 3051- (2023)

Externí odkaz: https://doaj.org/article/db1b9ee6eb774d2f85fb7d2ab4ac121d

Zobrazit plný text záznamu

Akademický článek

Genetic analyses of blood β-hydroxybutyrate predicted from milk infrared spectra and its association with longevity and female reproductive traits in Holstein cattle

Autor: W. Lou, H. Zhang, H. Luo, Z. Chen, R. Shi, X. Guo, Y. Zou, L. Liu, L.F. Brito, G. Guo, Y. Wang

Publikováno v: Journal of Dairy Science, Vol 105, Iss 4, Pp 3269-3281 (2022)

ABSTRACT: Ketosis is one of the most prevalent and complex metabolic disorders in high-producing dairy cows and usually detected through analyses of β-hydroxybutyrate (BHB) concentration in blood. Our main objectives were to evaluate genetic paramet

Externí odkaz: https://doaj.org/article/ff89c1674f144074b2c3eded5ab9c549

Zobrazit plný text záznamu

Akademický článek

Fluoride-leaching simulation of aquifer sediment and its influence on groundwater fluoride levels along coastal plains

Autor: C. P. Jia, Q. Chen, M. G. An, C. L. Zhi, S. W. Lou, P. P. Zhang, Q. C. Li, Y. M. Zhang, S. Y. Han, H. T. Zheng

Publikováno v: Water Supply, Vol 22, Iss 4, Pp 4133-4141 (2022)

Seawater intrusion and drinking-water fluorosis are frequently documented along coastal plains. Groundwater is characterized by high OH−, Na+, total dissolved solids, and low Ca2+ because of seawater intrusion, and such conditions favor sediment fl

Externí odkaz: https://doaj.org/article/284733d14e9e4a139482612602e688c0

Zobrazit plný text záznamu