Zobrazeno 1 - 10
of 203
pro vyhledávání: '"W Lesslauer"'
Publikováno v:
The Journal of Immunology. 157:3178-3182
The role of TNF and its type 1 receptor (TNFR1) in the pathogenesis of collagen-induced arthritis (CIA) was investigated in mice using two approaches. First, DBA/1 mice were treated after immunization with type II collagen by injecting TNFR1-IgG1 fus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aab3e3e78c8d9bba1d85a7465540b921
https://doi.org/10.4049/jimmunol.157.7.3178
https://doi.org/10.4049/jimmunol.157.7.3178
Autor:
William L. Castleman, Jean Nicolas Vauthey, U Ettlin, H Loetscher, Edward M. Copeland, B Wipf, Lyle L. Moldawer, S F Lowry, M B Welborn, W Lesslauer, K Van Zee, M. A. Rogy, Atsushi Kaibara, Jeffrey H. Pruitt, J S Kenney, Paul D. Edwards, D Stüber
Publikováno v:
The Journal of Experimental Medicine
Tumor necrosis factor (TNF) is a potentially useful adjunct to anticancer therapies. However, the clinical utility of TNF has been limited by generalized toxicity and hypotension. Recently, studies have begun to dissect the individual proinflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629c5607e933351e1a3679b49e2ade19
https://doi.org/10.1084/jem.184.1.165
https://doi.org/10.1084/jem.184.1.165
Autor:
L.A.H. Monnens, N.C.A.J. van de Kar, Mario A. Vermeer, V.W.H. van Hinsbergh, W. Lesslauer, T. Kooistra
Publikováno v:
Blood, 85, 3, pp. 734-743
Blood, 85, 734-743
Blood, 85, 734-743
Infections with verocytotoxin (VT) producing Escherichia coli have been strongly implicated in the epidemic form of hemolytic uremic syndrome (HUS). Endothelial damage plays a central role in the pathogenesis of HUS. In vitro studies have shown that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127a178529f3b02fdfb1fa27567bd1df
https://doi.org/10.1182/blood.v85.3.734.bloodjournal853734
https://doi.org/10.1182/blood.v85.3.734.bloodjournal853734
Publikováno v:
The Journal of Immunology. 153:5274-5284
The role of the two TNF receptor types, TNF-R55 and TNF-R75, was studied on mouse fibroblasts, taking advantage of TNF-R55-deficient mice generated by gene targeting (Tnfr1 degree-mice), and selectivity of human TNF-alpha for mouse TNF-R55. Radioliga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a71f3a5ed921da28532f6dc10cdadc89
https://doi.org/10.4049/jimmunol.153.11.5274
https://doi.org/10.4049/jimmunol.153.11.5274
Publikováno v:
Europe PubMed Central
Tumor necrosis factor alpha (TNF alpha) has previously been reported to have both inhibitory and stimulatory effects on hematopoietic progenitor cells. Specifically, TNF alpha has been proposed to stimulate early hematopoiesis in humans. In the prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c54530894d8bf18e270172008ec496
https://doi.org/10.1182/blood.v83.11.3152.bloodjournal83113152
https://doi.org/10.1182/blood.v83.11.3152.bloodjournal83113152
Autor:
Ricardo Díaz Martín, David L. Moyes, W Lesslauer, Jonathan Cohen, H Loetscher, Thomas J. Evans, A. Carpenter
Publikováno v:
The Journal of Experimental Medicine
The aim of this study was to compare the ability of both a 55- and 75-kD soluble tumor necrosis factor receptor immunoglobulin G fusion protein (sTNFR-IgG) in protecting against death in a murine model of gram-negative sepsis. Pretreatment with 250 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a8f804b2ccc883b3bad80b2187c6cb
http://europepmc.org/articles/PMC2191793
http://europepmc.org/articles/PMC2191793
Autor:
Walter Fiers, Wim Declercq, W Lesslauer, J. Grooten, Peter Vandenabeele, Dominique Vercammen, M Brockhaus, M. Van De Craen, H Loetscher
Publikováno v:
The Journal of Experimental Medicine
We investigated the biological role of the human tumor necrosis factor p75 (hTNF-R75), making use of the species specificity of TNF responses in murine (m) T cell lines. Several TNF-mediated activities on mouse T cells, such as cytokine induction or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9deff62ba5047acb926cb81be699fe0
https://doi.org/10.1084/jem.176.4.1015
https://doi.org/10.1084/jem.176.4.1015
Publikováno v:
The Journal of Immunology. 149:911-917
TNF is a highly pleiotropic cytokine. The recent identification of two distinct cellular receptors for TNF may provide explanations for the many different TNF activities. We have investigated the expression of the two receptor types, TNFR alpha (75 k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3df0ac70f84d9700fa61e9b44448ed0a
https://doi.org/10.4049/jimmunol.149.3.911
https://doi.org/10.4049/jimmunol.149.3.911
Publikováno v:
The Journal of Immunology. 146:3045-3048
In this study we investigated the expression of the 55 kDa (p55) and the 75 kDa (p75) TNF receptors in CD56+ NK cells and their role in NK and lymphokine-activated killer cells cell functions. By using mAb against the p55 and p75 TNF-R, NK cells were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42025ae5e6d7603d49f28ed94a2fb580
https://doi.org/10.4049/jimmunol.146.9.3045
https://doi.org/10.4049/jimmunol.146.9.3045
Autor:
Terje Espevik, W Lesslauer, M R Shalaby, Anders Sundan, Hansruedi Loetscher, Manfred Brockhaus
Publikováno v:
The Journal of Experimental Medicine
The present study was undertaken to further characterize the interaction of monoclonal antibodies (mAbs) against tumor necrosis factor (TNF) receptors with different targets, and to assess their ability to influence TNF effects on U937 and human endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ff6883e406d414e8d55e65759ba1d8
http://europepmc.org/articles/PMC2188665
http://europepmc.org/articles/PMC2188665