Zobrazeno 1 - 7
of 7
pro vyhledávání: '"W L Kurtz"'
Autor:
G P Dubé, Mais De, W L Kurtz, Joseph A. Jakubowski, K A Brune, Barbara G. Utterback, F. Mohamadi, M. M. Spees
Publikováno v:
ChemInform. 23
A number of phenylsulfonamido derivatives have been synthesized and tested for their ability to inhibit: a) thromboxane A 2 /prostaglandin H 2 ( TXA 2 PGH 2 ) mimetic (U46619)- induced guinea pig platelet aggregation; b) aortic ring contraction; and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49ece1fb41c54922e8e00239d2367fec
https://doi.org/10.1002/chin.199211127
https://doi.org/10.1002/chin.199211127
Autor:
G P Dubé, Joseph A. Jakubowski, M. M. Spees, K A Brune, W L Kurtz, Mais De, F. Mohamadi, Barbara G. Utterback
Publikováno v:
European Journal of Medicinal Chemistry. 26:821-827
A number of phenylsulfonamido derivatives have been synthesized and tested for their ability to inhibit: a) thromboxane A 2 /prostaglandin H 2 ( TXA 2 PGH 2 ) mimetic (U46619)- induced guinea pig platelet aggregation; b) aortic ring contraction; and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1f301f45a3bd88accce46d53a325f29
https://doi.org/10.1016/0223-5234(91)90009-c
https://doi.org/10.1016/0223-5234(91)90009-c
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 272(2)
A novel thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor ligand, (+)5(Z)-7-[3-endo-phenylsulfonylamino[2.2.1]-bicyclohept-2-e xo- yl]-heptenoic acid [(+)-S-145], was evaluated in guinea pigs to assess the in vivo pharmacodynamic profile of this c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::88afe9dd16cd1d188d9006eeafbfb08c
https://pubmed.ncbi.nlm.nih.gov/7853197
https://pubmed.ncbi.nlm.nih.gov/7853197
Autor:
G P, Dubé, D E, Mais, J A, Jakubowski, K A, Brune, B G, Utterback, T A, True, L E, Rinkema, W L, Kurtz
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 262(2)
The stereoisomers of S-145, a novel thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor ligand, were compared to TXA2/PGH2 receptor antagonists, SQ29548 and BM13505 in guinea pig platelets, aortas and trachea. Equilibrium binding assays in platelets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c25aca2ddc6af31778defc60720948d
https://pubmed.ncbi.nlm.nih.gov/1386888
https://pubmed.ncbi.nlm.nih.gov/1386888
Publikováno v:
Molecular pharmacology. 39(1)
Thromboxane A2 (TXA2) and prostaglandin H2 (PGH2) are potent constrictors of airway smooth muscle and may mediate some of the pulmonary effects of leukotrienes. To date, the TXA2/PGH2 receptor in lung has not been well characterized. In this report,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7beafd082cdab782b42c41f6c1b5cab8
https://pubmed.ncbi.nlm.nih.gov/1824791
https://pubmed.ncbi.nlm.nih.gov/1824791
Publikováno v:
Japanese Journal of Pharmacology. 75:54
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ab9819295ff2e0b4538e29a87c0fb2a
https://doi.org/10.1016/s0021-5198(19)41626-0
https://doi.org/10.1016/s0021-5198(19)41626-0
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 199(2)
Oral administration of l-propoxyphene with d-propoxyphene enhances the analgesic activity of d-propoxyphene as expressed in the rat tail heat test. The combination of d- and l-propoxyphene at a dose of 10 mg/kg each was found to have activity in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23638201e09a7237399dfc8b93286959
https://pubmed.ncbi.nlm.nih.gov/978493
https://pubmed.ncbi.nlm.nih.gov/978493