Zobrazeno 1 - 10
of 13
pro vyhledávání: '"W L Hanna"'
Autor:
Girish M. Shah, B M Babior, R. Christopher Bleackley, Jane Turbov, Roberta A. Gottlieb, Kim Orth, W. L. Hanna, Vishva M. Dixit, Prem Seth, Christopher J. Froelich
Publikováno v:
Journal of Biological Chemistry. 271:29073-29079
Lymphocyte granule-mediated apoptosis is postulated to entail the formation of membrane pores by perforin. Then soluble granzyme reaches the cytosol either through these pores or by reparative pinocytosis. We demonstrate here that Jurkat cells bind a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94f6d6bd7eae324517de613e1e3a02fd
https://doi.org/10.1074/jbc.271.46.29073
https://doi.org/10.1074/jbc.271.46.29073
Publikováno v:
Cellular Immunology. 171:159-163
Situated in secretory granules of cytotoxic cells, granzymes are essential for induction of target cell apoptosis with perforin. However, since cytotoxic cells constitutively secrete a portion of their synthesized granzymes, these proteases could med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03cdadfc52ad18a6b2d46e00e6689520
https://doi.org/10.1006/cimm.1996.0187
https://doi.org/10.1006/cimm.1996.0187
Publikováno v:
The Journal of Immunology. 153:4663-4672
We identified a chymotrypsin-like activity in the granules of IL-2 lymphokine-activated killer (LAK) cells and a NK cell line (YT) that reacted preferentially with the oligopeptide substrate succinyl-Phe-Leu-Phe-thiobenzyl ester (Suc-Phe-Leu-Phe-SBzl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80d0aa2bc24eb6cf983b1d257564b8ea
https://doi.org/10.4049/jimmunol.153.10.4663
https://doi.org/10.4049/jimmunol.153.10.4663
Publikováno v:
The Journal of Immunology. 151:7161-7171
Cartilage degradation, a hallmark of rheumatoid arthritis, is attributed to serine and metalloproteases secreted by neutrophils, synovial lining cells, macrophages, and chondrocytes. A large proportion of synovial fluid lymphocytes contains the granu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::172825d87e6b37c3dbb6924cab45e216
https://doi.org/10.4049/jimmunol.151.12.7161
https://doi.org/10.4049/jimmunol.151.12.7161
Publikováno v:
Protein Expression and Purification. 4:398-404
This report describes a simple scheme for the simultaneous purification of cationic human granzymes A, B, and 3 from human interleukin 2 (IL-2)-activated lymphocytes. The process, which requires approximately 8 h, includes: (1) cell cavitation, (2) t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28de4265d7449df6b8d895c12085cad6
https://doi.org/10.1006/prep.1993.1052
https://doi.org/10.1006/prep.1993.1052
Autor:
Kim Orth, W. L. Hanna, Guy G. Poirier, Hangjun Duan, Arul M. Chinnaiyan, Christopher J. Froelich, Vishva M. Dixit
Publikováno v:
Current Biology. 6:897-899
Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells provide immune surveillance against viruses and neoplasms, and play a central role in the pathogenesis of autoimmune disease, AIDS and graft rejection [1,2]. Thus, it is important to unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd02c7b13eaf77c5de72b4073f4ad30
https://doi.org/10.1016/s0960-9822(02)00614-0
https://doi.org/10.1016/s0960-9822(02)00614-0
Publikováno v:
Biochemical and biophysical research communications. 229(1)
Perforin, a potent pore-forming protein, plays an important role in lymphocyte-mediated cytolysis causing necrosis or, when combined with the granzymes, apoptosis. The studies on perforin, although already extensive, have been hampered by the limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4883cd7915fc6bc6c94648e980dece00
https://pubmed.ncbi.nlm.nih.gov/8954081
https://pubmed.ncbi.nlm.nih.gov/8954081
Autor:
W. L. Hanna, William C. Earnshaw, Emad S. Alnemri, Girish M. Shah, Patrick J. Duriez, Guy S. Salvesen, Guy G. Poirier, Christopher J. Froelich, Damien D’Amours
Publikováno v:
Biochemical and biophysical research communications. 227(3)
Cytotoxic lymphocytes utilize granule associated serine proteases (granzymes) and perforin to induce apoptosis. Although the importance of granzyme B has been established by gene ablation experiments, biochemical events initiated by the granzyme rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a3315bbf9bb4b74deacff4ed55bdc5
https://pubmed.ncbi.nlm.nih.gov/8885990
https://pubmed.ncbi.nlm.nih.gov/8885990
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 153(10)
We identified a chymotrypsin-like activity in the granules of IL-2 lymphokine-activated killer (LAK) cells and a NK cell line (YT) that reacted preferentially with the oligopeptide substrate succinyl-Phe-Leu-Phe-thiobenzyl ester (Suc-Phe-Leu-Phe-SBzl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8907c29b6b00fb8013e24d03c4878936
https://pubmed.ncbi.nlm.nih.gov/7963538
https://pubmed.ncbi.nlm.nih.gov/7963538
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 151(12)
Cartilage degradation, a hallmark of rheumatoid arthritis, is attributed to serine and metalloproteases secreted by neutrophils, synovial lining cells, macrophages, and chondrocytes. A large proportion of synovial fluid lymphocytes contains the granu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc62b285a0c8bdcb5bf66e0703537d96
https://pubmed.ncbi.nlm.nih.gov/8258716
https://pubmed.ncbi.nlm.nih.gov/8258716