Zobrazeno 1 - 10
of 12
pro vyhledávání: '"W L Casley"'
Autor:
E. G. Murphy, H K Cousin, H. Armstrong, A J Hudson, W. L. Casley, George C. Ebers, J. A. Abdalla
Publikováno v:
Scopus-Elsevier
Electrophysiologic studies in patients with autosomal dominant myotonia congenita (ADMC) have implicated defects of both muscle membrane sodium and chloride channels. An adult skeletal muscle sodium channel (ASkM1) gene maps to chromosome 17q23-25, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a4ad14cfdf7fba8bf89986eb76856b
https://ora.ox.ac.uk/objects/uuid:b15a79ef-b11f-487a-9774-eda06552b63a
https://ora.ox.ac.uk/objects/uuid:b15a79ef-b11f-487a-9774-eda06552b63a
Publikováno v:
Pharmacogenetics. 7:283-293
Susceptibility to acetaminophen-induced hepatotoxicity was found to vary widely in an outbred colony of Swiss Webster mice. Some acetaminophen-treated male mice showed a significant elevation in serum levels of the hepatic enzyme alanine aminotransfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3db2b89305e0dc20d993459bb6a5aa4
https://doi.org/10.1097/00008571-199708000-00003
https://doi.org/10.1097/00008571-199708000-00003
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 75:165-172
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14df0b5534fb298bb3d2d4d624d96c80
https://doi.org/10.1139/y97-013
https://doi.org/10.1139/y97-013
Autor:
Monika Tocchi, Nikolay Korokhov, David T. Curiel, Louise Larocque, Xuguang Li, D Huang, Wangxue Chen, Bozena Jaentschke, Alexander Pereboev, Caroline Gravel, W L Casley, Runtao He, M Lemieux
Publikováno v:
Gene Therapy
CD40 ligation has been shown to promote antigen-presenting functions of dendritic cells, which express CD40 receptor. Here we reported significantly altered biodistribution and immune responses with the use of CD40-targeted adenovirus. Compared with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940df4dbf64d6690de73b7c731e215ae
https://doi.org/10.1038/sj.gt.3303085
https://doi.org/10.1038/sj.gt.3303085
Publikováno v:
Canadian journal of physiology and pharmacology. 79(10)
CYP2C9 is the major P450 2C enzyme in human liver and contributes to the metabolism of a number of clinically important substrate drugs. This polymorphically expressed enzyme has been studied in Caucasian, Asian, and to some extent in African America
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c4562975640d346ae2d5387b5c9510af
https://pubmed.ncbi.nlm.nih.gov/11697742
https://pubmed.ncbi.nlm.nih.gov/11697742
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(12)
Caffeine metabolite ratios have been widely used to measure cytochrome P-450 1A2 activity in humans. Serum paraxanthine/caffeine ratio is one such index of this activity. We had previously demonstrated genetic variation of this trait among inbred mou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c760e3ea93765f1b92a7fa22246965fd
https://pubmed.ncbi.nlm.nih.gov/10570017
https://pubmed.ncbi.nlm.nih.gov/10570017
Publikováno v:
Canadian journal of physiology and pharmacology. 75(3)
The xenobiotic oxidation polymorphism associated with cytochrome P450 2D6 (CYP2D6) was investigated in 152 genetically related and unrelated healthy Inuit subjects living in the High Arctic of eastern Canada. Phenotyping was based on HPLC determinati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a24599271b26c6946fb2219a215cad3b
https://pubmed.ncbi.nlm.nih.gov/9164697
https://pubmed.ncbi.nlm.nih.gov/9164697
Publikováno v:
Biochemistry and molecular biology international. 38(6)
The cytochrome P450 and the glutathione systems are two major pathways of xenobiotic metabolism. We tested the effect of hepatic glutathione content on P450 CYP1A1/2 induction by 3,3',4,4'-tetrachlorobiphenyl in rainbow trout (Oncorhynchus mykiss). H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dac93dcf3514d26c4330991fdde7c30e
https://pubmed.ncbi.nlm.nih.gov/8739034
https://pubmed.ncbi.nlm.nih.gov/8739034
Publikováno v:
Cell biology and toxicology. 11(6)
Long-term culture of hepatocytes has been challenged by the loss of differentiated functions. In particular, there is a rapid decline in cytochrome P450 (CYP). In this study, we cocultured rat hepatocytes with 3T3 fibroblasts for 10 days, and examine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bfb3a540cb01ec6c7392ff992778b83
https://pubmed.ncbi.nlm.nih.gov/8788208
https://pubmed.ncbi.nlm.nih.gov/8788208
Autor:
H K Cousin, F. C. Cornelis, Michael Allon, A J Hudson, L. Hashimoto, W. L. Casley, Michael A. Crackower, S.S. Ting, Jacques S. Beckmann, George C. Ebers
Publikováno v:
Genomics. 14(2)
Hypokalemic periodic paralysis (HOKPP) is an autosomal dominant neuromuscular disorder characterized by flaccid paralysis accompanied by lowered serum potassium levels. We have tested polymorphic markers linked to the adult skeletal muscle sodium cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae3c38ba40cd3b589917a9ec7203f4d
https://pubmed.ncbi.nlm.nih.gov/1330884
https://pubmed.ncbi.nlm.nih.gov/1330884