Zobrazeno 1 - 10
of 10
pro vyhledávání: '"W L, Whitter"'
Autor:
M G, Bock, R M, DiPardo, B E, Evans, K E, Rittle, W L, Whitter, V M, Garsky, K F, Gilbert, J L, Leighton, K L, Carson, E C, Mellin
Publikováno v:
Journal of medicinal chemistry. 36(26)
A series of 3-(arylureido)-5-phenyl-1,4-benzodiazepines, nonpeptidal antagonists of the peptide hormone cholecystokinin (CCK), are described. Derived by reasoned modification of the CCK-A selective 3-carboxamido-1,4-benzodiazepine, MK-329, this paper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0aedb47e6d5ddb3fdbefec3bd6fac16
https://pubmed.ncbi.nlm.nih.gov/8277510
https://pubmed.ncbi.nlm.nih.gov/8277510
Autor:
James P. Springer, Tsing-Bau Chen, Robert M. DiPardo, Roger M. Freidinger, Paul J. Kling, Paul S. Anderson, D. J. Cerino, K. A. Kunkel, Daniel F. Veber, J. Hirshfield, W. L. Whitter, Kenneth E. Rittle, Ben E. Evans, Victor J. Lotti, George F. Lundell, Mark G. Bock, Raymond S.L. Chang
Publikováno v:
Journal of Medicinal Chemistry. 31:2235-2246
3-(Acylamino)-5-phenyl-2H-1,4-benzodiazepines, antagonists of the peptide hormone cholecystokinin (CCK), are described. Developed by reasoned modification of the known anxiolytic benzodiazepines, these compounds provide highly potent, orally effectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2a10119f966b8cde83db84bb2d17e6
https://doi.org/10.1021/jm00120a002
https://doi.org/10.1021/jm00120a002
Autor:
Robert M. DiPardo, W. L. Whitter, Daniel F. Veber, Roger M. Freidinger, Mark G. Bock, Kenneth E. Rittle, Ben E. Evans, Carl F. Homnick
Publikováno v:
ChemInform. 18
A new method for the resolution of amines and its application to 3-aminobenzodiazepines 1 is described. The method involves the synthesis and separation of a pair of phenylalanyl amide diastereomers followed by removal of phenylalanine via the Edman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd61497c77fc5f491196f21f1f290fd1
https://doi.org/10.1002/chin.198728219
https://doi.org/10.1002/chin.198728219
Autor:
J. A. MYERS, L. D. JUN. MOORE, W. L. WHITTER, S. L. COUNCIL, R. M. WALDO, J. L. LANIER, B. U. OMOJI
Publikováno v:
Chemischer Informationsdienst. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d72c71782109a8a19e3c39e95ee97b4f
https://doi.org/10.1002/chin.198029221
https://doi.org/10.1002/chin.198029221
Autor:
Roger M. Freidinger, Carl F. Homnick, Stephen F. Brady, P. Curley, William J. Paleveda, D. F. Veber, C. D. Colton, W. L. Whitter, Ruth F. Nutt
Publikováno v:
ChemInform. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec1968ca2011bde94f30eecd31a82a98
https://doi.org/10.1002/chin.198740336
https://doi.org/10.1002/chin.198740336
Autor:
Daniel F. Veber, Victor J. Lotti, K. A. Kunkel, Ben E. Evans, J. Hirshfield, W. L. Whitter, Tsing-Bau Chen, George F. Lundell, Mark G. Bock, Paul J. Kling, D. J. Cerino, James P. Springer, Roger M. Freidinger, Kenneth E. Rittle, Paul S. Anderson, Robert M. DiPardo, Raymond S.L. Chang
Publikováno v:
ChemInform. 20
3-(Acylamino)-5-phenyl-2H-1,4-benzodiazepines, antagonists of the peptide hormone cholecystokinin (CCK), are described. Developed by reasoned modification of the known anxiolytic benzodiazepines, these compounds provide highly potent, orally effectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70ab1649782ed313be1a632b8b0dc076
https://doi.org/10.1002/chin.198920215
https://doi.org/10.1002/chin.198920215
Autor:
R M, Freidinger, S F, Brady, W J, Paleveda, D S, Perlow, C D, Colton, W L, Whitter, R, Saperstein, E J, Brady, M A, Cascieri, D F, Veber
Publikováno v:
Psychopharmacology series. 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1d05164a5c395b11e4b202e91874f06f
https://pubmed.ncbi.nlm.nih.gov/2434945
https://pubmed.ncbi.nlm.nih.gov/2434945
Autor:
G A, Infante, P, Gonzalez, D, Cruz, J, Correa, J A, Myers, M F, Ahmad, W L, Whitter, A, Santos, P, Neta
Publikováno v:
Radiation research. 92(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aea73096a66f5e5610f7a12667032d3c
https://pubmed.ncbi.nlm.nih.gov/7163480
https://pubmed.ncbi.nlm.nih.gov/7163480
Autor:
N. P. Gould, P. J. King, D. F. Veber, Roger M. Freidinger, Tsing-Bau Chen, Carl F. Homnick, Mark G. Bock, Robert M. DiPardo, J. P. Springer, D. J. Cerino, Victor J. Lotti, B. E. Evans, P. S. Anderson, Kenneth E. Rittle, G. F. Lundell, K. A. Kunkel, W. L. Whitter, R. S. L. Chang, J. Hirshfield
Publikováno v:
ChemInform. 18
Coupling of the benzophenones (I) with D-tryptophan methyl ester hydrochloride (II) gives the benzodiazepinones (III).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::747c3dc8bb2bee2f1d09c71ff31e91f5
https://doi.org/10.1002/chin.198750243
https://doi.org/10.1002/chin.198750243
Autor:
Ben E. Evans, Carl F. Homnick, Roger M. Freidinger, Mark G. Bock, Robert M. DiPardo, Kenneth E. Rittle, W. L. Whitter, Daniel F. Veber
Publikováno v:
Tetrahedron Letters. 28:521-522
A new method for the resolution of amines and its application to 3-aminobenzodiazepines 1 is described. The method involves the synthesis and separation of a pair of phenylalanyl amide diastereomers followed by removal of phenylalanine via the Edman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2fea7e8cd3b7de81a3be364522e31ba
https://doi.org/10.1016/s0040-4039(00)95771-x
https://doi.org/10.1016/s0040-4039(00)95771-x