Zobrazeno 1 - 10
of 232
pro vyhledávání: '"W K Chiu"'
Autor:
Tingting Xie, Guangya Wang, Spencer C. Ding, Wing-Shan Lee, Suk Hang Cheng, Rebecca W. Y. Chan, Ze Zhou, Mary-Jane L. Ma, Diana S. C. Han, Jeremy Y. C. Teoh, W. K. Jacky Lam, Peiyong Jiang, Rossa W. K. Chiu, K. C. Allen Chan, Y. M. Dennis Lo
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-8 (2022)
Abstract Single-stranded ends of double-stranded DNA (jagged ends) are more abundant in urinary DNA than in plasma DNA. However, the lengths of jagged ends in urinary DNA remained undetermined, as a previous method used for urinary DNA jagged end seq
Externí odkaz:
https://doaj.org/article/e4eb0c32fae44646b1cdb1df9e10c7f5
Autor:
Meihui Chen, Rebecca W Y Chan, Peter P H Cheung, Meng Ni, Danny K L Wong, Ze Zhou, Mary-Jane L Ma, Liangbo Huang, Xinzhou Xu, Wing-Shan Lee, Guangya Wang, Kathy O Lui, W K Jacky Lam, Jeremy Y C Teoh, Chi-Fai Ng, Peiyong Jiang, K C Allen Chan, Rossa W K Chiu, Y M Dennis Lo
Publikováno v:
PLoS Genetics, Vol 18, Iss 7, p e1010262 (2022)
Urinary cell-free DNA (ucfDNA) is a potential biomarker for bladder cancer detection. However, the biological characteristics of ucfDNA are not well understood. We explored the roles of deoxyribonuclease 1 (DNASE1) and deoxyribonuclease 1-like 3 (DNA
Externí odkaz:
https://doaj.org/article/d9987df5b47d4a6084458cedce82ae43
Autor:
W. K. Jacky Lam, Peiyong Jiang, K. C. Allen Chan, Wenlei Peng, Huimin Shang, Macy M. S. Heung, Suk Hang Cheng, Haiqiang Zhang, O. Y. Olivia Tse, Radha Raghupathy, Brigette B. Y. Ma, Edwin P. Hui, Anthony T. C. Chan, John K. S. Woo, Rossa W. K. Chiu, Y. M. Dennis Lo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Epstein-Barr virus (EBV) is associated with different malignant diseases and circulating EBV DNA is a biomarker for nasopharyngeal carcinoma (NPC). Here, the authors report that plasma EBV DNA methylation profiles show disease-associated patterns and
Externí odkaz:
https://doaj.org/article/4628833b96ef42e198ec3810d5f38f5d
Autor:
Guangya Wang, W K Jacky Lam, Lowell Ling, Mary-Jane L Ma, Saravanan Ramakrishnan, Don C T Chan, Wing-Shan Lee, Suk Hang Cheng, Rebecca W Y Chan, Stephanie C Y Yu, Irene O L Tse, Wai Tat Wong, Peiyong Jiang, Rossa W K Chiu, K C Allen Chan, Y M Dennis Lo
Publikováno v:
Clinical Chemistry. 69:189-201
Background Nuclear-derived cell-free DNA (cfDNA) molecules in blood plasma are nonrandomly fragmented, bearing a wealth of information related to tissues of origin. DNASE1L3 (deoxyribonuclease 1 like 3) is an important player in shaping the fragmenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca71723b6e355068e4756551eabf03c
https://doi.org/10.1093/clinchem/hvac197
https://doi.org/10.1093/clinchem/hvac197
Autor:
Stephanie C Y Yu, Jiaen Deng, Rong Qiao, Suk Hang Cheng, Wenlei Peng, So Ling Lau, L Y Lois Choy, Tak Y Leung, John Wong, Vincent Wai-Sun Wong, Grace L H Wong, Peiyong Jiang, Rossa W K Chiu, K C Allen Chan, Y M Dennis Lo
Publikováno v:
Clinical Chemistry. 69:168-179
Background Recent studies using single molecule, real-time (SMRT) sequencing revealed a substantial population of analyzable long cell-free DNA (cfDNA) in plasma. Potential clinical utilities of such long cfDNA in pregnancy and cancer have been demon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b9a2f27dc66f5426bbe570a279561b
https://doi.org/10.1093/clinchem/hvac180
https://doi.org/10.1093/clinchem/hvac180
Autor:
Lilian Pok Wa, Zhong, Rossa W K, Chiu
Publikováno v:
Annual Review of Genomics and Human Genetics. 23:413-425
With the widespread clinical adoption of noninvasive screening for fetal chromosomal aneuploidies based on cell-free DNA analysis from maternal plasma, more researchers are turning their attention to noninvasive prenatal assessment for single-gene di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecebde262d3e3e9c7e34472e6041a8a7
https://doi.org/10.1146/annurev-genom-110821-113411
https://doi.org/10.1146/annurev-genom-110821-113411
Autor:
Ze Zhou, Mary-Jane L. Ma, Rebecca W. Y. Chan, W. K. Jacky Lam, Wenlei Peng, Wanxia Gai, Xi Hu, Spencer C. Ding, Lu Ji, Qing Zhou, Peter P. H. Cheung, Stephanie C. Y. Yu, Jeremy Y. C. Teoh, Cheuk-Chun Szeto, John Wong, Vincent W. S. Wong, Grace L. H. Wong, Stephen L. Chan, Edwin P. Hui, Brigette B. Y. Ma, Anthony T. C. Chan, Rossa W. K. Chiu, K. C. Allen Chan, Y. M. Dennis Lo, Peiyong Jiang
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Cell-free DNA (cfDNA) fragmentation is nonrandom, at least partially mediated by various DNA nucleases, forming characteristic cfDNA end motifs. However, there is a paucity of tools for deciphering the relative contributions of cfDNA cleavage pattern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebd9260fa464576f47f0fd91e97cfc65
https://doi.org/10.1073/pnas.2220982120
https://doi.org/10.1073/pnas.2220982120
Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
Spencer C Ding, Rebecca W Y Chan, Wenlei Peng, Liangbo Huang, Ze Zhou, Xi Hu, Stefano Volpi, Linda T Hiraki, Augusto Vaglio, Paride Fenaroli, Paola Bocca, Lai Shan Tam, Priscilla C H Wong, Lydia H P Tam, Peiyong Jiang, Rossa W K Chiu, K C Allen Chan, Y M Dennis Lo
Publikováno v:
Clinical Chemistry. 68:917-926
Background Jagged ends of plasma DNA are a recently recognized class of fragmentomic markers for cell-free DNA, reflecting the activity of nucleases. A number of recent studies have also highlighted the importance of jagged ends in the context of pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbffd12aa5fa85a4092c576d832f5156
https://doi.org/10.1093/clinchem/hvac050
https://doi.org/10.1093/clinchem/hvac050