Zobrazeno 1 - 10
of 428
pro vyhledávání: '"W K A Yung"'
Autor:
Nighat Noureen, Shaofang Wu, Yingli Lv, Juechen Yang, W. K. Alfred Yung, Jonathan Gelfond, Xiaojing Wang, Dimpy Koul, Andrew Ludlow, Siyuan Zheng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Telomerase activity correlates with distinct cell states, but can be challenging to quantify. Here the authors quantify telomerase activity across a range of biological samples using the expression of 13 genes, and show it correlates with cancer cell
Externí odkaz:
https://doaj.org/article/724dd20ce70c4007ae4d8becee60fbbd
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Pp 157-164 (2020)
Diffuse infiltrating gliomas are a clinically and molecularly heterogeneous group of tumors that are uniformly incurable. Despite our growing knowledge of genomic and epigenomic alterations in gliomas, standard treatments have not changed in the past
Externí odkaz:
https://doaj.org/article/4c323c61f07b468991c7ce82145bbf03
Autor:
Ingo K. Mellinghoff, Timothy F. Cloughesy, Minesh P. Mehta, Paul S. Mischel, John G. Kuhn, William H. Yong, Lisa M. DeAngelis, Andrew B. Lassman, Nian Wu, Steve Horvath, Howard A. Fine, Michael D. Prados, Susan M. Chang, Kathleen R. Lamborn, Patrick Y. Wen, Jan Drappatz, David A. Reardon, Mark R. Gilbert, W. K. Alfred Yung, Frank Lieberman, Linda M. Liau, Adriana Heguy, Cameron W. Brennan, Alicia Pedraza, Julie Dang, Daisuke Kuga, Akio Iwanami, Shaojun Zhu, Hui Tao, Nicolas Yannuzzi, Milan G. Chheda, Barbara Oldrini, Sara Kubek, Phioanh Leia Nghiemphu, Christian Grommes, Carl Campos, Daniel Rohle, H. Ian Robins, Igor Vivanco
mp3 file (11 MB). In the May edition of the Cancer Discovery podcast, Science Writer Elizabeth McKenna talks with Ingo K. Mellinghoff about his paper, which suggests that the disappointing clinical activity of first-generation EGFR inhibitors in glio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ea84dde1575a2f19855b3499939fbe
https://doi.org/10.1158/2159-8290.22529031.v1
https://doi.org/10.1158/2159-8290.22529031.v1
Autor:
Ingo K. Mellinghoff, Timothy F. Cloughesy, Minesh P. Mehta, Paul S. Mischel, John G. Kuhn, William H. Yong, Lisa M. DeAngelis, Andrew B. Lassman, Nian Wu, Steve Horvath, Howard A. Fine, Michael D. Prados, Susan M. Chang, Kathleen R. Lamborn, Patrick Y. Wen, Jan Drappatz, David A. Reardon, Mark R. Gilbert, W. K. Alfred Yung, Frank Lieberman, Linda M. Liau, Adriana Heguy, Cameron W. Brennan, Alicia Pedraza, Julie Dang, Daisuke Kuga, Akio Iwanami, Shaojun Zhu, Hui Tao, Nicolas Yannuzzi, Milan G. Chheda, Barbara Oldrini, Sara Kubek, Phioanh Leia Nghiemphu, Christian Grommes, Carl Campos, Daniel Rohle, H. Ian Robins, Igor Vivanco
PDF file - 689K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025f5ec99aaea9c2cde7f69d10999a40
https://doi.org/10.1158/2159-8290.22529022
https://doi.org/10.1158/2159-8290.22529022
Autor:
Ingo K. Mellinghoff, Timothy F. Cloughesy, Minesh P. Mehta, Paul S. Mischel, John G. Kuhn, William H. Yong, Lisa M. DeAngelis, Andrew B. Lassman, Nian Wu, Steve Horvath, Howard A. Fine, Michael D. Prados, Susan M. Chang, Kathleen R. Lamborn, Patrick Y. Wen, Jan Drappatz, David A. Reardon, Mark R. Gilbert, W. K. Alfred Yung, Frank Lieberman, Linda M. Liau, Adriana Heguy, Cameron W. Brennan, Alicia Pedraza, Julie Dang, Daisuke Kuga, Akio Iwanami, Shaojun Zhu, Hui Tao, Nicolas Yannuzzi, Milan G. Chheda, Barbara Oldrini, Sara Kubek, Phioanh Leia Nghiemphu, Christian Grommes, Carl Campos, Daniel Rohle, H. Ian Robins, Igor Vivanco
PDF file - 104K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb661e94c988b70550298ec4f5bac77
https://doi.org/10.1158/2159-8290.22529019
https://doi.org/10.1158/2159-8290.22529019
Autor:
Ingo K. Mellinghoff, Timothy F. Cloughesy, Minesh P. Mehta, Paul S. Mischel, John G. Kuhn, William H. Yong, Lisa M. DeAngelis, Andrew B. Lassman, Nian Wu, Steve Horvath, Howard A. Fine, Michael D. Prados, Susan M. Chang, Kathleen R. Lamborn, Patrick Y. Wen, Jan Drappatz, David A. Reardon, Mark R. Gilbert, W. K. Alfred Yung, Frank Lieberman, Linda M. Liau, Adriana Heguy, Cameron W. Brennan, Alicia Pedraza, Julie Dang, Daisuke Kuga, Akio Iwanami, Shaojun Zhu, Hui Tao, Nicolas Yannuzzi, Milan G. Chheda, Barbara Oldrini, Sara Kubek, Phioanh Leia Nghiemphu, Christian Grommes, Carl Campos, Daniel Rohle, H. Ian Robins, Igor Vivanco
PDF file - 133K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb57c1393865c3b35670662aac40d7a
https://doi.org/10.1158/2159-8290.22529025.v1
https://doi.org/10.1158/2159-8290.22529025.v1
Autor:
Patrick Y. Wen, Michael D. Prados, Igor Espinoza-Delgado, Matthew M. Ames, Xiabu Ye, Serena Desideri, Jihong Xu, Renee M. McGovern, Andrew B. Lassman, Frank S. Lieberman, H. Ian Robins, Mark R. Gilbert, W. K. Alfred Yung, Jan Drappatz, Susan M. Chang, Timothy F. Cloughesy, Kathleen R. Lamborn, John G. Kuhn, Joel M. Reid, Vinay K. Puduvalli, Eudocia Q. Lee
PDF file, 80K, Supplementary Table 1: Temozolomide 150 mg/m2 Pharmacokinetic Parameters (first cycle).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3218e25e18e7b4e6d8b65f1c7e87c4cd
https://doi.org/10.1158/1078-0432.22447476.v1
https://doi.org/10.1158/1078-0432.22447476.v1
Autor:
Patrick Y. Wen, Michael D. Prados, Igor Espinoza-Delgado, Matthew M. Ames, Xiabu Ye, Serena Desideri, Jihong Xu, Renee M. McGovern, Andrew B. Lassman, Frank S. Lieberman, H. Ian Robins, Mark R. Gilbert, W. K. Alfred Yung, Jan Drappatz, Susan M. Chang, Timothy F. Cloughesy, Kathleen R. Lamborn, John G. Kuhn, Joel M. Reid, Vinay K. Puduvalli, Eudocia Q. Lee
PDF file, 62K, Supplementary Table 2: Grade 3 or 4 events with relationship unrelated to unlikely to combination therapy (Vorinostat + TMZ).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3824c55e0724a5d0922ef42ae4b6c095
https://doi.org/10.1158/1078-0432.22447473.v1
https://doi.org/10.1158/1078-0432.22447473.v1
Autor:
Patrick Y. Wen, Michael D. Prados, Igor Espinoza-Delgado, Matthew M. Ames, Xiabu Ye, Serena Desideri, Jihong Xu, Renee M. McGovern, Andrew B. Lassman, Frank S. Lieberman, H. Ian Robins, Mark R. Gilbert, W. K. Alfred Yung, Jan Drappatz, Susan M. Chang, Timothy F. Cloughesy, Kathleen R. Lamborn, John G. Kuhn, Joel M. Reid, Vinay K. Puduvalli, Eudocia Q. Lee
Purpose: A phase I, dose-finding study of vorinostat in combination with temozolomide (TMZ) was conducted to determine the maximum tolerated dose (MTD), safety, and pharmacokinetics in patients with high-grade glioma (HGG).Experimental Design: This p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579e17f33f6813c56b74956393739952
https://doi.org/10.1158/1078-0432.c.6521082
https://doi.org/10.1158/1078-0432.c.6521082
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 351 (2020)
Glioblastoma is the most common malignant primary brain tumor in adults and is almost invariably fatal. Despite our growing understanding of the various mechanisms underlying treatment failure, the standard-of-care therapy has not changed over the la
Externí odkaz:
https://doaj.org/article/1d690acf045f40eb80989eac1b9864f9