Zobrazeno 1 - 10 of 26 pro vyhledávání: '"W Joshua Frazier"'
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Akademický článek
MAPK signaling drives inflammation in LPS-stimulated cardiomyocytes: the route of crosstalk to G-protein-coupled receptors.
Autor: W Joshua Frazier, Jianjing Xue, Wendy A Luce, Yusen Liu
Publikováno v: PLoS ONE, Vol 7, Iss 11, p e50071 (2012)
Profound cardiovascular dysfunction is an important cause of mortality from septic shock. The molecular underpinnings of cardiac dysfunction during the inflammatory surge of early sepsis are not fully understood. MAPKs are important signal transducer
Externí odkaz: https://doaj.org/article/7c8b78343e1447f59225b5d86b6d1ff0
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3
An Unusual Complication With the Administration of a Volatile Anesthetic Agent for Status Asthmaticus in the Pediatric Intensive Care Unit: Case Report and Review of the Literature
Autor: Brittany L Shutes, W. Joshua Frazier, Joseph D. Tobias
Publikováno v: Journal of Intensive Care Medicine. 32:400-404
In severe cases of status asthmaticus, when conventional therapies fail, volatile anesthetic agents remain a therapeutic option. When delivered outside of the operating room setting, specialized delivery techniques are needed to ensure the safe and e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74af6a9b340458a4891017ff4b1abca9
https://doi.org/10.1177/0885066617713169
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6
Development of a new interfacility extracorporeal membrane oxygenation transport program for pediatric lung transplantation evaluation
Autor: Samantha W. Gee, Edward G. Shepherd, W. Joshua Frazier
Publikováno v: Annals of translational medicine. 5(4)
Pediatric lung transplantation is a life-saving intervention for children with irreversible end-stage lung disease. Access to transplant can be limited by geographic isolation from a center or the presence of comorbidities affecting transplant eligib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c2bc4bdcd31d3781320c0b41f3fdc6
https://pubmed.ncbi.nlm.nih.gov/28275613
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7
Glutathione reductase is essential for host defense against bacterial infection
Autor: Yusen Liu, Leif D. Nelin, Xiaomei Meng, Melissa M. Ralston, W. Joshua Frazier, Charles V. Smith, Jing Yan, Amanda L. Jones, Rainer Benndorf, Lynette K. Rogers, Kathleen D. Bongiovanni
Publikováno v: Free Radical Biology and Medicine. 61:320-332
Glutathione reductase (Gsr)1 catalyzes the reduction of glutathione disulfide to glutathione, a major cellular antioxidant. We have recently shown that Gsr is essential for host defense against the Gram-negative bacteria Escherichia coli in a mouse m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83df4ba0568faa6e9028135faa411d2a
https://doi.org/10.1016/j.freeradbiomed.2013.04.015
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8
Knockout ofMkp-1exacerbates colitis inIl-10-deficient mice
Autor: Yusen Liu, Ranyia Matta, Jing Yan, Jianjing Xue, Jessica L. Grieves, W. Joshua Frazier, Andrew C.B. Cato, Leif D. Nelin, John Barnard, Lyn M. Wancket
Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 302:G1322-G1335
Il-10-deficient mice develop colitis associated with exaggerated Th1/Th17 responses and are a valuable model of inflammatory bowel disease. Mkp-1 is a major negative regulator of MAPKs, and its expression is enhanced by IL-10. To understand the role
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400498d4aa82dda73261f83ba2a8f7f2
https://doi.org/10.1152/ajpgi.00018.2012
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9
Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease
Autor: W. Joshua Frazier, Yusen Liu, Lyn M. Wancket
Publikováno v: Life Sciences. 90:237-248
Mitogen-activated protein kinases (MAPKs) are key regulators of cellular physiology and immune responses, and abnormalities in MAPKs are implicated in many diseases. MAPKs are activated by MAPK kinases through phosphorylation of the threonine and tyr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c8b4673331331b2a6e0b98f35e6165
https://doi.org/10.1016/j.lfs.2011.11.017
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10
Increased Inflammation, Impaired Bacterial Clearance, and Metabolic Disruption after Gram-Negative Sepsis in Mkp-1-Deficient Mice
Autor: Leif D. Nelin, Lyn M. Wancket, Xianxi Wang, W. Joshua Frazier, Yusen Liu, Xiaomei Meng, Xiang-An Li, Andrew C.B. Cato
Publikováno v: The Journal of Immunology. 183:7411-7419
MAPKs are crucial for TNF-α and IL-6 production by innate immune cells in response to TLR ligands. MAPK phosphatase 1 (Mkp-1) deactivates p38 and JNK, abrogating the inflammatory response. We have previously demonstrated that Mkp-1−/− mice exhib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ea50a8064a4dc61e935bfb62893ced0
https://doi.org/10.4049/jimmunol.0804343
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