Zobrazeno 1 - 10
of 113
pro vyhledávání: '"W Jim, Zheng"'
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-19 (2024)
Abstract Background The potential benefits of drug combination synergy in cancer medicine are significant, yet the risks must be carefully managed due to the possibility of increased toxicity. Although artificial intelligence applications have demons
Externí odkaz:
https://doaj.org/article/c54b658f28264d4380f2212e21308682
Autor:
Xiaohua Ye, David J. H. Shih, Zhiqiang Ku, Junping Hong, Diane F. Barrett, Richard E. Rupp, Ningyan Zhang, Tong-Ming Fu, W. Jim Zheng, Zhiqiang An
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-15 (2024)
Abstract Human cytomegalovirus (HCMV) is a leading infectious cause of birth defects and the most common opportunistic infection that causes life-threatening diseases post-transplantation; however, an effective vaccine remains elusive. V160 is a live
Externí odkaz:
https://doaj.org/article/9d0b8d649ccd4ae7bcacc3838138d7ee
Autor:
Chandra Sekhar Amara, Karthik Reddy Kami Reddy, Yang Yuntao, Yuen San Chan, Danthasinghe Waduge Badrajee Piyarathna, Lacey Elizabeth Dobrolecki, David J. H. Shih, Zhongcheng Shi, Jun Xu, Shixia Huang, Matthew J. Ellis, Andrea B. Apolo, Leomar Y. Ballester, Jianjun Gao, Donna E. Hansel, Yair Lotan, H. Courtney Hodges, Seth P. Lerner, Chad J. Creighton, Arun Sreekumar, W. Jim Zheng, Pavlos Msaouel, Shyam M. Kavuri, Nagireddy Putluri
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract SMARCB1 loss has long been observed in many solid tumors. However, there is a need to elucidate targetable pathways driving growth and metastasis in SMARCB1-deficient tumors. Here, we demonstrate that SMARCB1 deficiency, defined as genomic S
Externí odkaz:
https://doaj.org/article/92dacc4a9b18472087b40b7343faadf4
Autor:
Michael Hawrylycz, Maryann E Martone, Giorgio A Ascoli, Jan G Bjaalie, Hong-Wei Dong, Satrajit S Ghosh, Jesse Gillis, Ronna Hertzano, David R Haynor, Patrick R Hof, Yongsoo Kim, Ed Lein, Yufeng Liu, Jeremy A Miller, Partha P Mitra, Eran Mukamel, Lydia Ng, David Osumi-Sutherland, Hanchuan Peng, Patrick L Ray, Raymond Sanchez, Aviv Regev, Alex Ropelewski, Richard H Scheuermann, Shawn Zheng Kai Tan, Carol L Thompson, Timothy Tickle, Hagen Tilgner, Merina Varghese, Brock Wester, Owen White, Hongkui Zeng, Brian Aevermann, David Allemang, Seth Ament, Thomas L Athey, Cody Baker, Katherine S Baker, Pamela M Baker, Anita Bandrowski, Samik Banerjee, Prajal Bishwakarma, Ambrose Carr, Min Chen, Roni Choudhury, Jonah Cool, Heather Creasy, Florence D'Orazi, Kylee Degatano, Benjamin Dichter, Song-Lin Ding, Tim Dolbeare, Joseph R Ecker, Rongxin Fang, Jean-Christophe Fillion-Robin, Timothy P Fliss, James Gee, Tom Gillespie, Nathan Gouwens, Guo-Qiang Zhang, Yaroslav O Halchenko, Nomi L Harris, Brian R Herb, Houri Hintiryan, Gregory Hood, Sam Horvath, Bingxing Huo, Dorota Jarecka, Shengdian Jiang, Farzaneh Khajouei, Elizabeth A Kiernan, Huseyin Kir, Lauren Kruse, Changkyu Lee, Boudewijn Lelieveldt, Yang Li, Hanqing Liu, Lijuan Liu, Anup Markuhar, James Mathews, Kaylee L Mathews, Chris Mezias, Michael I Miller, Tyler Mollenkopf, Shoaib Mufti, Christopher J Mungall, Joshua Orvis, Maja A Puchades, Lei Qu, Joseph P Receveur, Bing Ren, Nathan Sjoquist, Brian Staats, Daniel Tward, Cindy T J van Velthoven, Quanxin Wang, Fangming Xie, Hua Xu, Zizhen Yao, Zhixi Yun, Yun Renee Zhang, W Jim Zheng, Brian Zingg
Publikováno v:
PLoS Biology, Vol 21, Iss 6, p e3002133 (2023)
Characterizing cellular diversity at different levels of biological organization and across data modalities is a prerequisite to understanding the function of cell types in the brain. Classification of neurons is also essential to manipulate cell typ
Externí odkaz:
https://doaj.org/article/5683e726eb424a3187544a44691a1d0f
Autor:
Michihiro Kobayashi, Haichao Wei, Takashi Yamanashi, Nathalia Azevedo Portilho, Samuel Cornelius, Noemi Valiente, Chika Nishida, Haizi Cheng, Augusto Latorre, W. Jim Zheng, Joonsoo Kang, Jun Seita, David J. Shih, Jia Qian Wu, Momoko Yoshimoto
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112239- (2023)
Summary: It is widely believed that hematopoiesis after birth is established by hematopoietic stem cells (HSCs) in the bone marrow and that HSC-independent hematopoiesis is limited only to primitive erythro-myeloid cells and tissue-resident innate im
Externí odkaz:
https://doaj.org/article/15fae9bc6d5246788df778501042a113
Autor:
Filipa Godoy-Vitorino, Hong Jiang, W Jim Zheng, Frederick F Lang, Joy Gumin, Lisha Zhu, Candelaria Gomez-Manzano, Juan Fueyo, Derek A Wainwright, Dong Ho Shin, Teresa T Nguyen, Sagar Sohoni, Sanjay K Singh, Yisel Rivera-Molina, Xuejun Fan, Christopher Alvarez-Breckenridge, Lijie Zhai, Erik Ladomersky, Kristen L Lauing, Marta M Alonso
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Background Oncolytic viruses are considered part of immunotherapy and have shown promise in preclinical experiments and clinical trials. Results from these studies have suggested that tumor microenvironment remodeling is required to achieve an effect
Externí odkaz:
https://doaj.org/article/1f2db7df16d848f1a1f3ecf672c1450b
Autor:
Zihao Yuan, Xuejun Fan, Jay-Jiguang Zhu, Tong-Ming Fu, Jiaqian Wu, Hua Xu, Ningyan Zhang, Zhiqiang An, W. Jim Zheng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Patient-derived xenografts are widely used for drug development, but the impact of murine viral infection remains underexplored. Here, the authors demonstrate the extensive existence of murine viral sequences in patient-derived xenografts and signifi
Externí odkaz:
https://doaj.org/article/c239a456dafd4db3ab6b1fee821051bc
Publikováno v:
Cancer Medicine, Vol 9, Iss 18, Pp 6776-6790 (2020)
Abstract The glioblastoma multiforme (GBM) is one of the deadliest tumors. It has been speculated that virus plays a role in GBM but the evidences are controversy. Published researches are mainly limited to studies on the presence of human cytomegalo
Externí odkaz:
https://doaj.org/article/04ac76cc942142b28a0c371fb0951468
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 19, Iss S1, Pp 1-9 (2019)
Abstract Background Disease comorbidity is very common and has significant impact on disease treatment. Revealing the associations among diseases may help to understand the mechanisms of diseases, improve the prevention and treatment of diseases, and
Externí odkaz:
https://doaj.org/article/4eb02b36eb00487dbaf0208cf07281fa
Autor:
Chun-Teh Lee, Ruoxing Li, Lisha Zhu, Gena D. Tribble, W. Jim Zheng, Brittney Ferguson, Krishna Rao Maddipati, Nikola Angelov, Thomas E. Van Dyke
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Failure of resolution pathways in periodontitis is reflected in levels of specialized pro-resolving lipid mediators (SPMs) and SPM pathway markers but their relationship with the subgingival microbiome is unclear. This study aimed to analyze and inte
Externí odkaz:
https://doaj.org/article/c332e72ecf644eb280d4d5429e1fa3f0