Zobrazeno 1 - 10
of 19
pro vyhledávání: '"W Jason Cummings"'
Autor:
Munehisa Yabuki, W Jason Cummings, John B Leppard, Robert M Immormino, Christi L Wood, Daniel S Allison, Patrick W Gray, Larry W Tjoelker, Nancy Maizels
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e36032 (2012)
Monoclonal antibodies (mAbs) can be potent and highly specific therapeutics, diagnostics and research reagents. Nonetheless, mAb discovery using current in vivo or in vitro approaches can be costly and time-consuming, with no guarantee of success. We
Externí odkaz:
https://doaj.org/article/a23b053ae13444a0a46f729efdb2b925
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e4075 (2008)
Homologous recombination is essential for maintaining genomic integrity. A common repair mechanism, it uses a homologous or homeologous donor as a template for repair of a damaged target gene. Such repair must be regulated, both to identify appropria
Externí odkaz:
https://doaj.org/article/c277b0a286c941ffaf306cb3a46c7e05
Autor:
W Jason Cummings, Munehisa Yabuki, Ellen C Ordinario, David W Bednarski, Simon Quay, Nancy Maizels
Publikováno v:
PLoS Biology, Vol 5, Iss 10, p e246 (2007)
Homology-directed repair is a powerful mechanism for maintaining and altering genomic structure. We asked how chromatin structure contributes to the use of homologous sequences as donors for repair using the chicken B cell line DT40 as a model. In DT
Externí odkaz:
https://doaj.org/article/b30f663330bf436b8962d9a8e05af45a
Publikováno v:
Blood. 140:5801-5802
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6deaba757db9c11b054584a2b1710bd
https://doi.org/10.1182/blood-2022-162828
https://doi.org/10.1182/blood-2022-162828
Autor:
Nicholas J. Lynch, Peter W. Andrew, Christi L. Wood, Robert B. Sim, W. Jason Cummings, Peter Garred, Teizo Fujita, Wilhelm J. Schwaeble, Gregory A. Demopulos, Sadam Yaseen, Steven H. Sacks, Munehisa Yabuki, Larry W. Tjoelker, Russell Wallis, Peter J. Lachmann, Thomas Dudler
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31(5)
All 3 activation pathways of complement-the classic pathway (CP), the alternative pathway, and the lectin pathway (LP)- converge into a common central event: the cleavage and activation of the abundant third complement component, C3, via formation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f3fd2e6d8fccab81a88ddfed4b6d6f
https://pubmed.ncbi.nlm.nih.gov/28188176
https://pubmed.ncbi.nlm.nih.gov/28188176
Autor:
Maria Grazia De Simoni, Teizo Fujita, W. Jason Cummings, Gregory A. Demopulos, Franca Orsini, Elvina Chrysanthou, Wilhelm J. Schwaeble, Minoru Takahashi, Thomas Dudler
Publikováno v:
Journal of Neuroinflammation
Background Complement activation via the lectin activation pathway (LP) has been identified as the key mechanism behind post-ischemic tissue inflammation causing ischemia-reperfusion injury (IRI) which can significantly impact the clinical outcome of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b76a830c3e3ef06f596fb4d7b3bf52
https://doi.org/10.1186/s12974-016-0684-6
https://doi.org/10.1186/s12974-016-0684-6
Autor:
Orsini, Franca, Chrysanthou, Elvina, Dudler, Thomas, W. Jason Cummings, Takahashi, Minoru, Teizo Fujita, Demopulos, Gregory, Maria-Grazia De Simoni, Schwaeble, Wilhelm
Orsini_Chrysanthou. (PDF 608 kb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c354aacef67d69703bdf1673a1a0fe8
Publikováno v:
The Journal of Immunology. 182:408-415
Rearranged Ig genes undergo diversification in sequence and structure initiated by the DNA deaminase, activation-induced deaminase. Ig genes must be transcribed for diversification to occur, but whether there are additional requirements for cis activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c796c5158b7d8c85c40767043713211b
https://doi.org/10.4049/jimmunol.182.1.408
https://doi.org/10.4049/jimmunol.182.1.408
Publikováno v:
Molecular Cell. 20(3):367-375
MRE11/RAD50/NBS1 (MRN) is a ubiquitous complex that participates in the response to DNA damage and in immunoglobulin (Ig) gene diversification. Ig gene diversification is initiated by deamination of cytosine to uracil, followed by removal of uracil t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0008f8c8c95678d07a4b46b2d6ae8f6
Publikováno v:
Nucleic Acids Research
The human serine protease inhibitor (serpin) gene cluster at 14q32.1 is a useful model system to study cell-type-specific gene expression and chromatin structure. Activation of the serpin locus can be induced in vitro by transferring human chromosome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d9d8b0df6af4e807c86e69f0da042c
https://doi.org/10.1093/nar/gki645
https://doi.org/10.1093/nar/gki645