Zobrazeno 1 - 10
of 357
pro vyhledávání: '"W Janes"'
Autor:
Elliot D. Drew, Robert W. Janes
Publikováno v:
BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background Following the recent outbreak of the new coronavirus pandemic (Covid-19), the rapid determination of the structure of the homo-trimeric spike glycoprotein has prompted the study reported here. The aims were to identify potential
Externí odkaz:
https://doaj.org/article/a471587c93fa4dc8b16027eddc05b941
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 315 (2023)
Eph receptor tyrosine kinases play critical functions during development, in the formation of tissue and organ borders, and the vascular and neural systems. Uniquely among tyrosine kinases, their activities are controlled by binding to membrane-bound
Externí odkaz:
https://doaj.org/article/9b91db1d028346d69233eaaf4513c6c2
Autor:
Míriam Javier-Torrent, Sergi Marco, Daniel Rocandio, Maria Pons-Vizcarra, Peter W Janes, Martin Lackmann, Joaquim Egea, Carlos A Saura
Publikováno v:
eLife, Vol 8 (2019)
EphA/ephrin signaling regulates axon growth and guidance of neurons, but whether this process occurs also independently of ephrins is unclear. We show that presenilin-1 (PS1)/γ-secretase is required for axon growth in the developing mouse brain. PS1
Externí odkaz:
https://doaj.org/article/9e21efe51dcd4079bb72e8d40b6a248c
Autor:
Martin Lackmann, Andrew M. Scott, Glenn Cartwright, David Abramson, Slavisa Garic, Carmen Llerena, Geoffrey Yarranton, Christopher Bebbington, Varghese Palath, Mark Baer, Fook-Thean Lee, Peter W. Janes, Degu Abebe, Linda Hii, April Tan, Carmel Murone, Mary E. Vail
Methods: List of Antibodies, reagents and cell lines Table S1: Distribution of EphA3 protein in human cancers assessed by IHC. Table S2: Kinetic properties of mouse IIIA4 and chimeric IIIA4 for binding to EphA3 Figure S1: Expression patterns of EphA3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31207dbbabb64a07eee4f63e27883a51
https://doi.org/10.1158/0008-5472.22403676.v1
https://doi.org/10.1158/0008-5472.22403676.v1
Autor:
Hengkang Yan, Mary E. Vail, Linda Hii, Nancy Guo, Paul J. McMurrick, Karen Oliva, Simon Wilkins, Nayanendu Saha, Dimitar B. Nikolov, Fook-Thean Lee, Andrew M. Scott, Peter W. Janes
Publikováno v:
Cancers; Volume 14; Issue 13; Pages: 3171
ADAM10 is a transmembrane metalloprotease that sheds a variety of cell surface proteins, including receptors and ligands that regulate a range of developmental processes which re-emerge during tumour development. While ADAM10 is ubiquitously expresse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e918cd161ee75dbafcc392733e8079
An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth
Autor:
Ulrike Kusebauch, Zhanqi Liu, Matthias Ernst, Shahin Rafii, Martin Lackmann, Andrew M. Scott, Lakmali Atapattu, Katja Horvay, Linda Hii, Moritz F. Eissman, Dimitar B. Nikolov, Chanly Chheang, Zhongwei Cao, Helen E. Abud, Bi-Sen Ding, Kai Xu, Nayanendu Saha, Carmen Llerena, Robert L. Moritz, Mary E. Vail, Peter W. Janes
Publikováno v:
The Journal of Experimental Medicine
Janes et al. developed an anti-ADAM10 mAb (8C7) that binds to an active form of ADAM10 present in tumors, particularly in stem-like cells. Administration of 8C7 inhibits Notch activity and tumor growth in mouse models, including regrowth after chemot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf5e1be2a19ef93692b5afad9f2f905
Publikováno v:
Pharmaceuticals, Vol 13, Iss 5, p 88 (2020)
The Eph subfamily of receptor tyrosine kinases mediate cell-cell communication controlling cell and tissue patterning during development. While generally less active in adult tissues, they often re-emerge in cancers, particularly on undifferentiated
Externí odkaz:
https://doaj.org/article/09149a8f336840329bd807b6ed6cd181
Publikováno v:
Crops; Volume 2; Issue 4; Pages: 415-427
Industrial hemp (Cannabis sativa L.) as a grain and fiber crop is experiencing a resurgence in North America. Due to governmental prohibition, there has been limited information on regional agronomic production systems including basic information on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b0235a76ca7a7b5de0bc6411b7e06e
Autor:
Nayanendu Saha, Du-San Baek, Rachelle P. Mendoza, Dorothea Robev, Yan Xu, Yehuda Goldgur, M. Jason De La Cruz, Elisa de Stanchina, Peter W. Janes, Kai Xu, Dimiter S. Dimitrov, Dimitar B. Nikolov
Publikováno v:
Biomedicine & Pharmacotherapy. 161:114494
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38b20a6c27fbac511b8f98954235677f
https://doi.org/10.1016/j.biopha.2023.114494
https://doi.org/10.1016/j.biopha.2023.114494
Autor:
Joshua M. Katzenstein, Christopher J. Ellison, Nikhil B. Hira, Julia D. Cushen, Dana L. McGuffin, Dustin W. Janes, Nathan A. Prisco
Publikováno v:
ACS macro letters. 1(10)
Polystyrene (PS) that has been exposed to ultraviolet light (UV) undergoes partial dehydrogenation of the alkane polymer backbone which increases its surface energy. Exploiting this photochemistry, we exposed polystyrene films to UV light using a pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6c30f4dbdbf8d6d32a148c00ffbaf8
https://pubmed.ncbi.nlm.nih.gov/35607202
https://pubmed.ncbi.nlm.nih.gov/35607202