Výsledky vyhledávání - "W J van Blitterswijk"

Membrane organization determines barrier properties of endothelial cells and short-chain sphingolipid-facilitated doxorubicin influx

Autor: Dayana Martins Gueth, Gerben A Koning, W J van Blitterswijk, Marcel Verheij, A.J. van Hell, Andrey S. Klymchenko

Publikováno v: Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1841(9), 1301-1307. Elsevier

The endothelial lining and its outer lipid membrane are the first major barriers drug molecules encounter upon intravenous administration. Our previous work identified lipid analogs that counteract plasma membrane barrier function for a series of amp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7fb6c0a2582f5be066d92fdd0febd8
https://pure.eur.nl/en/publications/cfaa1b1a-a263-47ca-bc58-0fc988e3b4c7

Zobrazit plný text záznamu

Negative regulation of diacylglycerol kinase θ mediates adenosine-dependent hepatocyte preconditioning

Autor: Emanuele Albano, Mariapaola Nitti, Andrea Graziani, W J van Blitterswijk, M. Gaggianesi, C. Imarisio, R. Carini, Gianluca Baldanzi, C. Dal Ponte, E. Alchera, Cinzia Domenicotti

Publikováno v: Cell Death & Differentiation. 17:1059-1068

In liver ischemic preconditioning (IP), stimulation of adenosine A2a receptors (A2aR) prevents ischemia/reperfusion injury by promoting diacylglycerol-mediated activation of protein kinase C (PKC). By concerting diacylglycerol to phosphatidic acid, d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bac9a80eeb0c6c11e9e21145a596fee
https://doi.org/10.1038/cdd.2009.210

Zobrazit plný text záznamu

Diacylglycerol kinase-α phosphorylation by Src on Y335 is required for activation, membrane recruitment and Hgf-induced cell motility

Autor: Gianluca Baldanzi, Andrea Graziani, Paolo E. Porporato, Fabiola Sinigaglia, Federico Bussolino, Elena Rainero, Viola F. Gnocchi, Federica Chianale, Nicoletta Filigheddu, Santina Cutrupi, W J van Blitterswijk, Ornella Parolini

Publikováno v: Oncogene. 27:942-956

Diacylglycerol (DAG) kinases (Dgk), which phosphorylate DAG to generate phosphatidic acid, act as either positive or negative key regulators of cell signaling. We previously showed that Src mediates growth factors-induced activation of Dgk-alpha, who

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960376f9885080a99f713e59a435da10
https://doi.org/10.1038/sj.onc.1210717

Zobrazit plný text záznamu

N-hexanoyl-sphingomyelin potentiates in vitro doxorubicin cytotoxicity by enhancing its cellular influx

Autor: Robert Jan Veldman, W J van Blitterswijk, Marcel Verheij, Shuraila F. Zerp

Publikováno v: British Journal of Cancer

Anticancer drugs generally have intracellular targets, implicating transport over the plasma membrane. For amphiphilic agents, such as the anthracycline doxorubicin, this occurs by passive diffusion. We investigated whether exogenous membrane-permeab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d798cefeb917ce21b058c824843890cf
http://europepmc.org/articles/PMC2410169

Zobrazit plný text záznamu

Sphingolipids related to apoptosis from the point of view of membrane structure and topology

Autor: W. J. van Blitterswijk, A. H. van der Luit, W. Caan, M. Verheij, J. Borst

Publikováno v: Biochemical Society Transactions. 29:819-824

Sphingolipids and their metabolites are implicated in signal transduction, but the mechanisms are still poorly understood. In particular, the presumed function of ceramide as a second messenger remains controversial. Here, we emphasize the importance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b48c3001f02576fa7c2a0c81db0a9d4c
https://doi.org/10.1042/bst0290819

Zobrazit plný text záznamu

Lysophosphatidic acid-induced Ca2+ mobilization in human A431 cells: structure-activity analysis

Autor: Marie-Françoise Simon, Hugues Chap, W J van Blitterswijk, Kees Jalink, G. A. Van Der Marel, Trudi Hengeveld, S Mulder, J. H. Van Boom, Wouter H. Moolenaar, Friso R. Postma

Publikováno v: Biochemical Journal. 307:609-616

Lysophosphatidic acid (LPA; 1-acyl-sn-glycero-3-phosphate) is a platelet-derived lipid mediator that activates its own G-protein-coupled receptor to trigger phospholipase C-mediated Ca2+ mobilization and other effector pathways in numerous cell types

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9511dc4522c532d256379d7add14250d
https://doi.org/10.1042/bj3070609

Zobrazit plný text záznamu

Diacylglycerol kinase in receptor-stimulated cells converts its substrate in a topologically restricted manner

Autor: R L van der Bend, J de Widt, W J van Blitterswijk, Henk Hilkmann

Publikováno v: Journal of Biological Chemistry. 269:4098-4102

The regulation of diacylglycerol (DG) kinase activity was studied in fibroblasts and Jurkat T cells. We questioned whether enzyme activity only depends on substrate availability or whether it requires receptor stimulation. To this end, we raised DG l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbb5d3be0d76c6b9ed4daade4d7f68dc
https://doi.org/10.1016/s0021-9258(17)41748-0

Zobrazit plný text záznamu

Rapid attenuation of receptor-induced diacylglycerol and phosphatidic acid by phospholipase D-mediated transphosphatidylation: formation of bisphosphatidic acid

Autor: Henk Hilkmann, W J van Blitterswijk

Publikováno v: The EMBO Journal. 12:2655-2662

Generation and attenuation of lipid second messengers are key processes in cellular signalling. Receptor-mediated increase in 1,2-diacylglycerol (DG) levels is attenuated by DG kinase and DG lipase. We here report a novel mechanism of DG attenuation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17aafad43a946ed493a7c3be5aef03b3
https://doi.org/10.1002/j.1460-2075.1993.tb05926.x

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání