Zobrazeno 1 - 10
of 359
pro vyhledávání: '"W J Howe"'
Autor:
Donald J. Abraham
Publikováno v:
Journal of Medicinal Chemistry. 42:5284-5284
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f335881f66eb34411944c34ad20ac7bc
https://doi.org/10.1021/jm990497r
https://doi.org/10.1021/jm990497r
Autor:
Abraham, D. J.
Publikováno v:
Journal of Medicinal Chemistry; December 16, 1999, Vol. 42 Issue: 25 p5284-5284, 1p
Autor:
D J Rothrock, Carol A. Bannow, C S Tomich, J M Lull, A. M. Mildner, I M Reardon, J L Sarcich, Clark W. Smith, W J Howe, Joseph W. Leone
Publikováno v:
Biochemistry. 33:9405-9413
Site-directed mutagenesis of autolysis sites in the human immunodeficiency virus type 1 (HIV-1) protease was applied in an analysis of enzyme specificity; the protease served, therefore, as both enzyme and substrate in this study. Inspection of natur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c53661bef00e283b8c61084e47454c
https://doi.org/10.1021/bi00198a005
https://doi.org/10.1021/bi00198a005
Autor:
W. J. Howe, W. T. Lowther, J. O. Hui, W. G. Tarpley, D. E. Emmert, Chetana Rao, A G Tomasselli, John H. Kinner, V. S. Bradford, D. L. Alexander, Tomi K. Sawyer, B.M. Dunna, Robert A. Conradi, D. L. Decamp, Clark W. Smith, Allen W. Harrison, Charles S. Craik, James Michael Tustin, T. J. Mcquade, Robert L. Heinrikson, Y. Z. Zhang, Philip S. Burton, Jed F. Fisher, Roger A. Poorman, Joseph B. Moon, Jackson B. Hester, D J Staples, L. Liu, P. E. Scarborough, Maggiora Linda Louise
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:819-824
The structure-activity relationships and pharmacophore modeling aspects of a series of HIV PR inhibitors modified at the N- and/or C-terminus of the dipeptide isostere ChaΨ[CH(OH)CH2]Val (Cha, cyclohexylalanine) are reported. The HIV PR binding affi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b57d250dd9d5791ff9b0e19fb8eaad6
https://doi.org/10.1016/s0960-894x(00)80673-3
https://doi.org/10.1016/s0960-894x(00)80673-3
Autor:
L. Liu, Alexander Wlodawer, Tomi K. Sawyer, D. L. Decamp, Robert L. Heinrikson, K. O'connell, Ben M. Dunn, Joseph B. Moon, Jackson B. Hester, D J Staples, Mariusz Jaskolski, Jennifer L. Harris, Roger A. Poorman, Heinrich J. Schostarez, Clark W. Smith, A G Tomasselli, J. O. Hui, Charles S. Craik, W. J. Howe, W. T. Lowther
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d23a689ed0032396aa16b956d37ebfc
https://doi.org/10.1002/chin.199307301
https://doi.org/10.1002/chin.199307301
Autor:
W. J. Howe, W. T. Lowther, A G Tomasselli, D. E. Emmert, D J Staples, Jackson B. Hester, W. G. Tarpley, J. O. Hui, Ben M. Dunn, John H. Kinner, Robert L. Heinrikson, Y. Z. Zhang, Tomi K. Sawyer, Charles S. Craik, D. L. Decamp, James Michael Tustin, T. J. Mcquade, D. L. Alexander, Allen W. Harrison, P. E. Scarborough, Robert A. Conradi, Jed F. Fisher, Roger A. Poorman, Philip S. Burton, Maggiora Linda Louise, V. S. Bradford, Joseph B. Moon, L. Liu, Clark W. Smith, Chetana Rao
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b99dbead49d3038ea527912ab65dad7
https://doi.org/10.1002/chin.199509217
https://doi.org/10.1002/chin.199509217
Autor:
Strohbach Joseph Walter, Lester A. Dolak, K. A. Curry, A.M. Mulichak, Steve Turner, Chong Kt, D. J. Rothrock, M.N. Janakiraman, M.‐M. Horng, Che-Shen C. Tomich, Suvit Thaisrivongs, R. R. Hinshaw, Paul K. Tomich, J. C. Lynn, W. J. Howe, Joseph B. Moon, K. D. Watenpaugh, A G Tomasselli
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb145004efa30b2a03ad7411fa1e93eb
https://doi.org/10.1002/chin.199552133
https://doi.org/10.1002/chin.199552133
Publikováno v:
Proteins: Structure, Function, and Genetics. 11:314-328
The design of molecules to bind specifically to protein receptors has long been a goal of computer-assisted molecular design. Given detailed structural knowledge of the target receptor, it should be possible to construct a model of a potential ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27d93fc1c420995d1d4705cd88dd0ca
https://doi.org/10.1002/prot.340110409
https://doi.org/10.1002/prot.340110409
Autor:
W. J. Howe, Robert L. Heinrikson, Carol A. Bannow, J. O. Hui, A G Tomasselli, D L DeCamp, I M Reardon, C S Craik, D J Staples, Tomi K. Sawyer
Publikováno v:
Journal of Biological Chemistry. 265:14675-14683
Highly purified, recombinant preparations of the virally encoded proteases from human immunodeficiency viruses (HIV) 1 and 2 have been compared relative to 1) their specificities toward non-viral protein and synthetic peptide substrates, and 2) their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfa638659f7a59d753b524a0b8f2aa9a
https://doi.org/10.1016/s0021-9258(18)77355-9
https://doi.org/10.1016/s0021-9258(18)77355-9
Publikováno v:
Volume 3: Heat Transfer; Electric Power; Industrial and Cogeneration.
The heat transfer distribution on the hub endwall of a model turbine vane passage was studied experimentally and by numerical simulation. The experiments were carried out in a low speed wind tunnel featuring a linear cascade of scaled-up inlet vanes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b435feaab80bc16cbf9e8633fca78b84
https://doi.org/10.1115/2000-gt-0198
https://doi.org/10.1115/2000-gt-0198