Zobrazeno 1 - 10
of 23
pro vyhledávání: '"W J, Underberg"'
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 17:979-984
The physical instability of proteins and peptides as well as the various analytical techniques used to study the various aspects of physical instability have been reviewed. Physical instability of proteins and peptides involve changes in secondary, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06632d14cef036a6872d5be8e24d033
https://doi.org/10.1016/s0731-7085(98)00064-8
https://doi.org/10.1016/s0731-7085(98)00064-8
Autor:
J A, Cadée, M J, van Steenbergen, C, Versluis, A J, Heck, W J, Underberg, W, den Otter, W, Jiskoot, W E, Hennink
Publikováno v:
Pharmaceutical research. 18(10)
The oxidation of recombinant human interleukin-2 (rhlL-2) by potassium peroxodisulfate (KPS) with or without N,N,N',N'-tetramethylethylenediamine (TEMED), which are used for the preparation of dextran-based hydrogels, was investigated.The oxidation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8eff1192b8caeeb67d88f84be4c3950e
https://pubmed.ncbi.nlm.nih.gov/11697473
https://pubmed.ncbi.nlm.nih.gov/11697473
Autor:
J C, Waterval, P, Bestebreurtje, H, Lingeman, C, Versluis, A J, Heck, A, Bult, W J, Underberg
Publikováno v:
Electrophoresis. 22(13)
This paper describes several successful cost-effective attempts to couple capillary electrophoresis (CE) and mass spectrometry (MS) without make-up flow or nebulizing gas. An in-depth analysis of several interfaces using conductive spray tips was per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4cc1e3c33ce87fbb6d0d3b12a59f60b1
https://pubmed.ncbi.nlm.nih.gov/11545395
https://pubmed.ncbi.nlm.nih.gov/11545395
Autor:
J C, Waterval, G, Hommels, P, Bestebreurtje, C, Versluis, A J, Heck, A, Bult, H, Lingeman, W J, Underberg
Publikováno v:
Electrophoresis. 22(13)
An earlier developed capillary electrophoresis (CE) system with an on-capillary adsorptive phase is investigated for its suitability to quantitate low concentrations of angiotensin II and gonadorelin in plasma. An off-line solid-phase extraction is u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c028f9199e739dff31a93b62c361ec05
https://pubmed.ncbi.nlm.nih.gov/11545396
https://pubmed.ncbi.nlm.nih.gov/11545396
Publikováno v:
Electrophoresis. 21(18)
This survey gives an overview of recent derivatization protocols, starting from 1996, in combination with capillary electrophoresis (CE). Derivatization is mainly used for enhancing the detection sensitivity of CE, especially in combination with lase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb3a1e8b8bb0094b9bbd825be3c24dd1
https://pubmed.ncbi.nlm.nih.gov/11192122
https://pubmed.ncbi.nlm.nih.gov/11192122
Autor:
M A, Hoitink, J H, Beijnen, A, Bult, J M, Damen, O A, van der Houwen, J A, Kruijtzer, M M, Tibben, G, Wiese, W J, Underberg
Publikováno v:
Journal of pharmaceutical sciences. 89(1)
Three model tripeptides, N-acetyl-Tyr-Pro-azaGly-NH(2) (NYPaG), Tyr-Pro-azaGly-NH(2) (YPaG), and Tyr-Pro-Gly-NH(2)(YPG), were subjected to a systematic degradation study to get information about the degradation of the azaglycinamido residue. The degr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cfdcab562eeb203719d814cc5062d06d
https://pubmed.ncbi.nlm.nih.gov/10664543
https://pubmed.ncbi.nlm.nih.gov/10664543
Publikováno v:
Electrophoresis. 20(14)
Low levels of peptide drugs in human plasma can be determined employing off-line solid-phase extraction, followed by capillary zone electrophoresis with UV detection. A bioanalytical procedure is presented, using gonadorelin and angiotensin II in hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::788d519f4a240dd73cb2564bda94f65b
https://pubmed.ncbi.nlm.nih.gov/10546827
https://pubmed.ncbi.nlm.nih.gov/10546827
Autor:
M A, Hoitink, J H, Beijnen, M U, Boschma, A, Bult, O A, van der Houwen, G, Wiese, W J, Underberg
Publikováno v:
Pharmaceutical research. 15(9)
To develop a method for calculating epimerisation parameters, find out if the kinetics of the independent reactions can be established, and elucidate primary structure-chemical degradation relationships in the degradation kinetics of three gonadoreli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e58bda0587b3f412cc22c740babba1c8
https://pubmed.ncbi.nlm.nih.gov/9755899
https://pubmed.ncbi.nlm.nih.gov/9755899
Publikováno v:
Anticancer research. 18(3B)
The pharmacokinetics of ifosfamide and some metabolites in children was investigated. The patients received various doses of ifosfamide, mostly by continuous infusion, over several days. The penetration of ifosfamide and its metabolites into the cere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad647cfa1374c163463f5bbf848c491e
https://pubmed.ncbi.nlm.nih.gov/9677448
https://pubmed.ncbi.nlm.nih.gov/9677448
Autor:
J D, Jonkman-de Vries, B J, Van den Bemt, W W, ten Bokkel-Huinink, W J, Underberg, J J, Kettenes-van den Bosch, R E, Henrar, A, Bult, J H, Beijnen
Publikováno v:
PDA journal of pharmaceutical science and technology. 51(2)
A stable parenteral dosage form for the investigational cytotoxic drug clanfenur was designed, and the bulk drug was characterized by its nuclear magnetic resonance, mass spectrometry, infrared, and ultraviolet spectra. The 1H and 13C spectra show cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d96950671229f8c2024fc5f27ca36b8
https://pubmed.ncbi.nlm.nih.gov/9146040
https://pubmed.ncbi.nlm.nih.gov/9146040