Zobrazeno 1 - 10 of 350 pro vyhledávání: '"W J, Sandborn"'
1
P696 Design and rationale for the multicentre, randomised, controlled VERDICT trial to determine the optimal treatment target in patients with ulcerative colitis
Autor: V Jairath, G Zou, G Radulescu, J Sigler, S C Mcfarlane, S Adsul, M Freire, L Peyrin-Biroulet, J F Colombel, G W Moran, S Sebastian, S Travis, S Vermeire, W J Sandborn, G R D’Haens, B G Feagan
Publikováno v: Journal of Crohn's and Colitis. 17:i826-i829
Background Symptoms, endoscopy, histology, and biomarkers are used to evaluate disease activity and response to therapy in ulcerative colitis (UC). Histologic disease activity may persist in ~25% of patients with normal-appearing endoscopic mucosa, a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e0d2f7adef5008ee0566e2981e1ba79
https://doi.org/10.1093/ecco-jcc/jjac190.0826
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2
P270 A global consensus on the definitions, diagnosis and management of fibrostenosing small bowel Crohn’s disease
Autor: D Bettenworth, M E Baker, W Bemelmann, D Bruining, G D’Haens, A D’Hoore, A Dignass, I Dotan, B G Feagan, R Feakins, P Fleshner, J G Fletcher, I Gordon, C Ha, H Gaylyn, V Jairath, C Lu, R Lyu, S C Ng, J Panes, G Rogler, R Mao, J Rimola, W J Sandborn, B Siegmund, M S Silverberg, S Taylor, B Verstockt, F Rieder
Publikováno v: Journal of Crohn's and Colitis. 17:i418-i420
Background Small bowel fibrostenotic strictures are common in patients with Crohn’s disease (CD). No global consensus recommendations on definitions, diagnosis and clinical management are available. Methods Several systematic reviews followed by a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fccc6ad6d832170368b6761072c90c0f
https://doi.org/10.1093/ecco-jcc/jjac190.0400
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3
P588 Interim results from the randomised VERDICT trial to determine the optimal treatment target in patients with ulcerative colitis
Autor: V Jairath, G Zou, Z Wang, S Adsul, J F Colombel, G R D’Haens, M Freire, G W Moran, L Peyrin-Biroulet, W J Sandborn, S Sebastian, S Travis, S Vermeire, G Radulescu, J Sigler, S Mcfarlane, N Arya, M Beaton, P Bossuyt, D Green, W Harlan III, M Horynski, M Klopocka, R Petroniene, M S Silverberg, L Wolanski, B G Feagan
Publikováno v: Journal of Crohn's and Colitis. 17:i716-i717
Background The optimal treatment target for ulcerative colitis (UC) is uncertain. The VERDICT trial in moderate to severe UC aims to determine if a treatment target of corticosteroid (CS)-free symptomatic + endoscopic + histologic remission is superi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22db2fd8ff2832b977771a3a5e02fe5a
https://doi.org/10.1093/ecco-jcc/jjac190.0718
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4
P748 Pharmacokinetics, relative bioavailability, and dose proportionality of a tablet formulation of the sphingosine 1-phosphate-1 receptor modulator VTX002 (formerly OPL-002)
Autor: R Gregg, C Yun, S Naik, M Huyghe, J Harris, R Mohan, J Nuss, W J Sandborn
Publikováno v: Journal of Crohn's and Colitis. 17:i878-i879
Background VTX002 is an oral selective sphingosine 1-phosphate-1 receptor (S1P1R) modulator in clinical development for treatment of ulcerative colitis (UC). Single and multiple doses of a spray-dried dispersion (SDD) oral suspension of VTX002 were w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fe07bfc949a824b2142acc74ab4fef8
https://doi.org/10.1093/ecco-jcc/jjac190.0878
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5
DOP83 Efficacy and Safety of Ustekinumab for Ulcerative Colitis Through 3 Years: UNIFI Long-term Extension
Autor: Ramesh P. Arasaradnam, David Rowbotham, Rupert W. Leong, Maria T. Abreu, L Peyrin-Biroulet, W J Sandborn, Ilia Tikhonov, Bruce E. Sands, Y Miao, Ellen Scherl, Hongyan Zhang, Waqqas Afif, Silvio Danese, Colleen Marano, Remo Panaccione, Tadakazu Hisamatsu
Publikováno v: Journal of Crohn's and Colitis. 15:S113-S115
Background Ustekinumab (UST) is an IL-12/23p40 antagonist used to treat pts with moderate-to-severe ulcerative colitis (UC). The ongoing UNIFI long-term extension (LTE) evaluates subcutaneous (SC) 90mg UST maintenance therapy, with efficacy (wk152) a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a3f829230853dcf775f7212d2266b30
https://doi.org/10.1093/ecco-jcc/jjab073.122
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6
A15 EFFICACY AND SAFETY OF FILGOTINIB AS INDUCTION THERAPY FOR PATIENTS WITH MODERATELY TO SEVERELY ACTIVE ULCERATIVE COLITIS: RESULTS FROM THE PHASE 2B/3 SELECTION STUDY
Autor: B G Feagan, E V Loftus, S Danese, S Vermeire, W J Sandborn, T Ritter, R Mehta, U Seidler, F Seibold, I Beales, H Kim, J McNally, C Yun, S Zhao, X Liu, C Tasset, R Besuyen, M Watanabe, S Schreiber, G Rogler, T Hibi, L Peyrin-Biroulet
Publikováno v: Journal of the Canadian Association of Gastroenterology. 4:18-20
Aims The SELECTION (NCT02914522) Induction Studies evaluated the efficacy/safety of filgotinib (FIL), a preferential JAK1 inhibitor, as induction therapy for patients (pts) with moderately to severely active ulcerative colitis (UC) who were biologic-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3230785ef83404c220385d0fff2d3b14
https://doi.org/10.1093/jcag/gwab002.014
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10
P475 Association between disease duration and degree of endoscopic improvement in patients with ulcerative colitis treated with tofacitinib
Autor: Rajiv Mundayat, Daniel Quirk, W J Sandborn, Xiang Guo, Irene Modesto, Chinyu Su, Javier P. Gisbert, Walter Reinisch, Michael Chiorean
Publikováno v: Journal of Crohn's and Colitis. 14:S416-S418
Background Tofacitinib is an oral, small-molecule JAK inhibitor for the treatment of ulcerative colitis (UC). Efficacy and safety of tofacitinib in patients with UC were evaluated in two Phase 3 induction studies (OCTAVE Induction 1 and 2; NCT0146576
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33da60621166092ebe387f075a529691
https://doi.org/10.1093/ecco-jcc/jjz203.604
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