Zobrazeno 1 - 10
of 17
pro vyhledávání: '"W J, Ryves"'
Autor:
Adrian J. Harwood, W. J. Ryves
Publikováno v:
Biochemical and Biophysical Research Communications. 280:720-725
The mechanism by which lithium (Li(+)) inhibits the protein kinase glycogen synthase kinase-3 (GSK-3) is unknown. Here, we demonstrate that Li(+) is a competitive inhibitor of GSK-3 with respect to magnesium (Mg(2+)), but not to substrate or ATP. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45099a419d1d01075ab4d059dbd1e16d
https://doi.org/10.1006/bbrc.2000.4169
https://doi.org/10.1006/bbrc.2000.4169
Publikováno v:
The EMBO Journal. 18:2734-2745
The therapeutic properties of lithium ions (Li+) are well known; however, the mechanism of their action remains unclear. To investigate this problem, we have isolated Li+-resistant mutants from Dictyostelium. Here, we describe the analysis of one of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9abed90b51d49c22ed4209a98cf13f0
https://doi.org/10.1093/emboj/18.10.2734
https://doi.org/10.1093/emboj/18.10.2734
Autor:
Philip C. Gordge, A.T. Evans, B. Thomas, Pawan Sharma, N. Shaun, Peter J. Parker, Fred J. Evans, W. J. Ryves
Publikováno v:
Journal of Pharmacy and Pharmacology. 47:297-306
We have separated a resiniferatoxin-stimulated histone-kinase activity from human neutrophils, elicited mouse macrophages and murine alveolar macrophages by hydroxyapatite chromatography. The assay conditions for resiniferatoxin kinase were optimized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e9b0891d503a023a3fca46058f3e48d
https://doi.org/10.1111/j.2042-7158.1995.tb05799.x
https://doi.org/10.1111/j.2042-7158.1995.tb05799.x
Publikováno v:
Journal of Pharmacy and Pharmacology. 47:30-33
Rat isolated small intestine and mesentery were perfused with a gelatin-containing physiological salt solution, and microvascular permeability in the villi was assessed using colloidal carbon as a marker to assess the effect of sapintoxin A in this e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15d243a44b37b509484529db373686ce
https://doi.org/10.1111/j.2042-7158.1995.tb05729.x
https://doi.org/10.1111/j.2042-7158.1995.tb05729.x
Publikováno v:
FEBS Letters. 288:5-9
Phorbol esters, tetradecanoylphorbolacetate, sapintoxin-A, 12-deoxyphorbol-phenylacetate, 12-deoxyphorbol-phenylacetate-20-acetate, thymeleatoxin and resiniferatoxin were investigated for their abilities to activate the PKC-isotypes α, β1, γ, δ a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc30277b8a13ea503810d99fc4e6c32c
https://doi.org/10.1016/0014-5793(91)80989-g
https://doi.org/10.1016/0014-5793(91)80989-g
Autor:
Fred J. Evans, A.T. Evans, Peter J. Parker, Pankaj Sharma, W. J. Ryves, Thomas S, Philip C. Gordge, Andrée R. Olivier
Publikováno v:
Biochemical Society Transactions. 19:397-402
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44302ab0d163ac13368ecdbadbd38487
https://doi.org/10.1042/bst0190397
https://doi.org/10.1042/bst0190397
Autor:
Britta J. Eickholt, H. Nau, K. Adley, D. Eikel, L. M. J. Ylinen, Adrian J. Harwood, W. J. Ryves, N. H. Chadborn, G. J. Towers, Robin S.B. Williams
Publikováno v:
Molecular pharmacology. 67(5)
Inositol-1,4,5-trisphosphate (InsP3) depletion has been implicated in the therapeutic action of bipolar disorder drugs, including valproic acid (VPA). It is not currently known whether the effect of VPA on InsP3 depletion is related to the deleteriou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0adb0df6091f5d40081eb11939481e6c
https://pubmed.ncbi.nlm.nih.gov/15687223
https://pubmed.ncbi.nlm.nih.gov/15687223
Autor:
Emma Dalton, Robin S.B. Williams, W. J. Ryves, Britta J. Eickholt, Galit Shaltiel, Adrian J. Harwood, Galila Agam
Publikováno v:
Europe PubMed Central
BASE-Bielefeld Academic Search Engine
BASE-Bielefeld Academic Search Engine
Lithium (Li+), a mood stabilizer, has profound effects on cultured neurons, offering an opportunity to investigate its cellular biological effects. Here we consider the effect of Li+ and other psychotropic drugs on growth cone morphology and chemotax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d8a876bf5da92e5ea909e313460944
https://pubmed.ncbi.nlm.nih.gov/15494019
https://pubmed.ncbi.nlm.nih.gov/15494019
Autor:
Adrian J. Harwood, Rebecca S. Ginger, M. Fukuzawa, W. J. Ryves, Emma Dalton, Jeffrey G. Williams
Extracellular cAMP stimulates the rapid tyrosine phosphorylation and nuclear translocation of the DICTYOSTELIUM: STAT protein Dd-STATa. Here we show that it also induces serine phosphorylation by GskA, a homologue of glycogen synthase kinase-3 (GSK-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed7e8c3fdba3e35a1b14141157a8b757
https://europepmc.org/articles/PMC314011/
https://europepmc.org/articles/PMC314011/
Publikováno v:
Molecular pharmacology. 48(2)
A mixed micellar assay was used to study the in vitro binding of [3H]phorbol-12, 13-dibutyrate ([3H]PDBu) to pure recombinant protein kinase C (PKC)-alpha, -beta 1, -beta 2, -gamma, -delta, -epsilon, and -zeta isotypes expressed in the baculovirus/in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::58a562f3ff7d9b3505b89f2380d5a0c9
https://pubmed.ncbi.nlm.nih.gov/7651359
https://pubmed.ncbi.nlm.nih.gov/7651359