Zobrazeno 1 - 10
of 103
pro vyhledávání: '"W J, Rutter"'
Publikováno v:
Journal of Virology. 67:9-18
We reported previously that an N-terminally truncated insulinlike growth factor I receptor (IGFR) fused to avian sarcoma virus UR2 gag p19 had a greater transforming potential than did the native IGFR, but it failed to cause tumors in vivo. To invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b80eb450760641018afb603269d281
https://doi.org/10.1128/jvi.67.1.9-18.1993
https://doi.org/10.1128/jvi.67.1.9-18.1993
Publikováno v:
Biochemical Journal. 288:631-635
H2O2 and vanadate are known insulinomimetic agents. Together they induce insulin's bioeffects with a potency which exceeds that seen with insulin, vanadate or H2O2 alone. We have previously shown that a combination of H2O2 and vanadate, when added to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1faf668762dbf715340f6eff1553d7a5
https://doi.org/10.1042/bj2880631
https://doi.org/10.1042/bj2880631
Publikováno v:
Molecular and Cellular Biology. 12:1777-1788
The pancreatic beta cell makes several unique gene products, including insulin, islet amyloid polypeptide (IAPP), and beta-cell-specific glucokinase (beta GK). The functions of isolated portions of the insulin, IAPP, and beta GK promoters were studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ca11af46e1507c3073693708fe30bc
https://doi.org/10.1128/mcb.12.4.1777-1788.1992
https://doi.org/10.1128/mcb.12.4.1777-1788.1992
Publikováno v:
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology. 12:295-301
Enzymatic activity and mRNA abundance for neutral bile salt-dependent cholesteryl ester hydrolase (CEH) were determined in rat and rabbit tissues. In rat liver and intestine, enzyme activity and mRNA levels varied independently. Particularly striking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f58a7f7179a00a367fc0330ab7a9f6
https://doi.org/10.1161/01.atv.12.3.295
https://doi.org/10.1161/01.atv.12.3.295
Publikováno v:
Journal of Biological Chemistry. 265:9505-9511
Internalization, degradation, and insulin-induced down-regulation of insulin receptors were studied comparatively in transformed Chinese hamster ovary (CHO) cell lines, CHO.T and CHO.IR.ros, respectively expressing either the wild-type human insulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe4db0c426950917e929a2bc2b741970
https://doi.org/10.1016/s0021-9258(19)38878-7
https://doi.org/10.1016/s0021-9258(19)38878-7
Publikováno v:
Molecular and Cellular Biology. 10:464-473
The human insulinlike growth factor I receptor was overexpressed in NIH 3T3 cells as well as human and rat primary fibroblast strains. The NIH 3T3 cells displayed a ligand-dependent, highly transformed phenotype. When exposed to insulinlike growth fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a23cfb2967708de46311f35f786ec06
https://doi.org/10.1128/mcb.10.2.464-473.1990
https://doi.org/10.1128/mcb.10.2.464-473.1990
Publikováno v:
FEBS letters. 383(1-2)
Trypsin and chymotrypsin have specificity pockets of essentially the same geometry, yet trypsin is specific for basic while chymotrypsin for bulky hydrophobic residues at the P1 site of the substrate. A model by Steitz, Henderson and Blow suggested t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::82bc0f9a1fcc0235a46ca23cf4c26c05
https://pubmed.ncbi.nlm.nih.gov/8635580
https://pubmed.ncbi.nlm.nih.gov/8635580
Publikováno v:
The Journal of biological chemistry. 269(14)
Human insulin-like growth factor-1 (hIGF-1) contains seven positively charged residues in the A-, C-, and D-regions that are not present in similar positions in insulin. To determine whether these residues contribute to receptor binding specificity f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f450e1c1a4ed5eb45b987fdfdb5ba115
https://pubmed.ncbi.nlm.nih.gov/8144650
https://pubmed.ncbi.nlm.nih.gov/8144650
Publikováno v:
Protein science : a publication of the Protein Society. 1(4)
Arg-127 stabilizes the oxyanion of the tetrahedral intermediate formed during Zn2+ carboxypeptidase A-catalyzed hydrolysis. Mutant carboxypeptidases lacking Arg-127 exhibit substantially reduced rates of hydrolysis with the change manifest almost ent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::02ba9fe7ab9a9e24f56b682d08f5f50f
https://pubmed.ncbi.nlm.nih.gov/1304353
https://pubmed.ncbi.nlm.nih.gov/1304353
Publikováno v:
Biotechnology (Reading, Mass.). 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d9dc2e4f062148a6db2487b9ed5f970
https://pubmed.ncbi.nlm.nih.gov/1422020
https://pubmed.ncbi.nlm.nih.gov/1422020