Výsledky vyhledávání - "W J, Metzler"

Immunologic and molecular characterization of Amb p V allergens from Ambrosia psilostachya (western Ragweed) pollen

Autor: B Ghosh, T Rafnar, M P Perry, D Bassolino-Klimas, W J Metzler, D G Klapper, D G Marsh

Publikováno v: The Journal of Immunology. 152:2882-2889

We have purified and characterized the Amb p V allergen (A1 variant) from western ragweed (Ambrosia psilostachya) pollen. This allergen was found to be highly cross-reactive with the Amb a VA1 allergen from short ragweed (A. artemisiifolia) pollen in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3102f467ae62d7c2843a7091527016ee
https://doi.org/10.4049/jimmunol.152.6.2882

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Expression and analysis of recombinant Amb a V and Amb t V allergens. Comparison with native proteins by immunological assays and NMR spectroscopy

Autor: T Rafnar, Shau-Ku Huang, Balaram Ghosh, L. Mueller, David G. Marsh, M. P. Perry, W. J. Metzler

Publikováno v: Journal of Biological Chemistry. 267:21119-21123

The Amb V allergens are small, highly disulfide-bonded ragweed pollen allergens that serve as useful models for understanding the molecular basis of the human immune response. We have produced recombinant Amb a V and Amb t V (from short and giant rag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0d0174b7d21e758edb3d220442f0c6c
https://doi.org/10.1016/s0021-9258(19)36805-x

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Simulated annealing with restrained molecular dynamics using a flexible restraint potential: theory and evaluation with simulated NMR constraints

Autor: D, Bassolino-Klimas, R, Tejero, S R, Krystek, W J, Metzler, G T, Montelione, R E, Bruccoleri

Publikováno v: Protein science : a publication of the Protein Society. 5(4)

A new functional representation of NMR-derived distance constraints, the flexible restraint potential, has been implemented in the program CONGEN (Bruccoleri RE, Karplus M, 1987, Biopolymers 26:137-168) for molecular structure generation. In addition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0fc293e45397b6800f2b8d75d5a5c0ce
https://pubmed.ncbi.nlm.nih.gov/8845749

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Immunologic and molecular characterization of Amb p V allergens from Ambrosia psilostachya (western Ragweed) pollen

Autor: B, Ghosh, T, Rafnar, M P, Perry, D, Bassolino-Klimas, W J, Metzler, D G, Klapper, D G, Marsh

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 152(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::518a9339fae1fbe6ccdb8e2da727834d
https://pubmed.ncbi.nlm.nih.gov/7511632

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Identification of the poly-L-proline-binding site on human profilin

Autor: W J, Metzler, A J, Bell, E, Ernst, T B, Lavoie, L, Mueller

Publikováno v: The Journal of biological chemistry. 269(6)

Profilin is a ubiquitous protein that has been implicated in the signaling pathway leading to cytoskeletal rearrangement in cells. An unusual property of profilin is its high binding affinity for poly-L-proline (PLP). This binding property is conserv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::13a184581d799b039632e5a77e97e634
https://pubmed.ncbi.nlm.nih.gov/8308034

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Characterization of the three-dimensional solution structure of human profilin: 1H, 13C, and 15N NMR assignments and global folding pattern

Autor: W J, Metzler, K L, Constantine, M S, Friedrichs, A J, Bell, E G, Ernst, T B, Lavoie, L, Mueller

Publikováno v: Biochemistry. 32(50)

Human profilin is a 15-kDa protein that plays a major role in the signaling pathway leading to cytoskeletal rearrangement. Essentially complete assignment of the 1H, 13C, and 15N resonances of human profilin have been made by analysis of multidimensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1a2d25878bc9daea4192b605ef5cd4a7
https://pubmed.ncbi.nlm.nih.gov/8268157

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Expression and analysis of recombinant Amb a V and Amb t V allergens. Comparison with native proteins by immunological assays and NMR spectroscopy

Autor: T, Rafnar, B, Ghosh, W J, Metzler, S K, Huang, M P, Perry, L, Mueller, D G, Marsh

Publikováno v: The Journal of biological chemistry. 267(29)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6a3ef7f3cc2ff3b081ba8497ca1b4654
https://pubmed.ncbi.nlm.nih.gov/1400422

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Determining local conformational variations in DNA. Nuclear magnetic resonance structures of the DNA duplexes d(CGCCTAATCG) and d(CGTCACGCGC) generated using back-calculation of the nuclear Overhauser effect spectra, a distance geometry algorithm and constrained molecular dynamics

Autor: W J, Metzler, C, Wang, D B, Kitchen, R M, Levy, A, Pardi

Publikováno v: Journal of molecular biology. 214(3)

Two-dimensional nuclear magnetic resonance (n.m.r.) spectroscopy and a variety of computational techniques have been used to generate three-dimensional structures of the two DNA duplexes d(CGCCTAATCG) and d(CGTCACGCGC). The central six base-pairs in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::799bd91efd0923462be622515d60d909
https://pubmed.ncbi.nlm.nih.gov/2167379

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